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The Role of a Glycoprotein K (gK) CD8+ T-Cell Epitope of Herpes Simplex Virus on Virus Replication and Pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2009;50(6):2903-2912. doi:10.1167/iovs.08-2957
Figure Legend:
Effect of gK peptides on virus replication in eyes of mice and rabbits. (A) Virus titers in tears of BALB/c mouse treated
with gK peptide 2. One hour before ocular infection with 2 × 105 PFU/eye of HSV-1 strain McKrae, BALB/c mice
received 100 μg/eye of gK peptide 2 in eye drops. Control mice received 100 μg/eye of gK peptides 1, gK peptide 3, gD
peptide, or VSV-G peptide. Tear swabs were collected from infected eyes on day 1 after ocular infection and virus titers
were determined by standard plaque assays. Each point represents the mean titer from 30 eyes from two separate
experiments. (B) Virus titers in tears of BALB/c and C57BL/6 mice treated with the gK 8mer. All procedures were as in
(A) of
except
that the
experimental group
gK 8merfor
and
controls
the S-8mer.
For the ©BALB/c
mice,
each
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point represents the mean of 110 eyes from seven separate experiments. For the C57BL/6 mice, each point represents