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CURRICULUM VITAE
James H. Holda, Ph.D.
Business Address:
University of Akron
Department of Biology
Akron, Ohio 44325
(330) 972-5116
email [email protected]
Education:
1972-76
1979-82
Positions:
1977-78
University of Michigan
Dearborn, MI
B.S., Biology, 1976
Wayne State University School of Medicine
Detroit, MI
Ph.D., Immunology/Microbiology, 1982
Research Technician
Wayne State University
Detroit, MI
1978-79
Research Assistant
Wayne State University
Detroit, MI
1980-81
Laboratory Instructor in Immunology/Microbiology
Wayne State University School of Medicine
Detroit, MI
1982-85
Postdoctoral Fellow (under Henry N. Claman, M.D.)
Division of Clinical Immunology
UCHSC, Denver, CO 80262
1985-87
Instructor
Department of Microbiology/Immunology
UCHSC, Denver, CO 80262
1987-91
Assistant Professor
Department of Biology
University of Akron
Akron, Ohio 44325
1991- Associate Professor
Department of Biology
University of Akron
Akron, Ohio 44325
Honors:
Recipient of Wayne State University’s Sigma XI graduate
student research award
Graduation with Honors from University of Michigan
Recipient of NIH Training Grant
Univ. of Akron, Board of Trustees Outstanding Faculty Award (1992-93)
Grants
Awarded:
1985-87
Leukemia Society Special Fellowship Award
1988-89
Ohio Challenge Grant
1998 Stoller grant
2000 Faculty research grant
Professional Societies:
American Association of Immunologists
Ohio academy of Science
University Committees:
Radiation Safety Committee – Serve as Chair on alternating 3yr rotation
Biology Honors Preceptor, 2000
IACUC Chair, 2002-
Publications:
Referred Journals:
1. Welch AM, Holda JH, Swanborg RH, Regulation of experimental allergic
encephalomyelitis. II. Appearance of suppressor cells during the remission of the
disease. J. Immunol. 125:186-189, 1980.
2. Holda JH, Swanborg RH, Susceptibility of Lewis rats to experimental
autoimmune encephalomyelitis after recovery from passively-induced disease. Imm.
Communication 9:333-337, 1980.
3. Holda JH, Welch AM, Swanborg RH, Autoimmune effector cells I. Transfer of
experimental autoimmune encephalomyelitis with lymphoid cells cultured with
antigen. Eur. J. Immunol.10:657-659, 1980.
4. Holda JH, Swanborg RH, Regulation of experimental allergic encephalomyelitis .
III. Demonstration of effector cells in tolerant rats. Eur. J. Immunol. 11:338-340,
1981.
5. Holda JH, Swanborg RH, Autoimmune effector cells. II. Transfer of
experimental allergic encephalomyelitis with a subset of T lymphocytes. Eur. J.
Immunol. 12:453-455, 1982.
6. Killen JA, Holda JH, Swanborg RH, Helix Pomatia receptor on rat T lymphocytes
and bone marrow cells. Imm. Communications 11:293-302, 1982.
7. Holda JH, Silberg D, Swanborg RH, Autoimmune effector cells. IV: Induction of
experimental allergic encephalomyelitis in Lewis rats without adjuvant. J. Immunol.
130:732-733, 1983.
8. Holda JH, Maier T, Claman HN, Graft-versus-host reactions across minor murine
histocompatibility barriers. I. Impairment of mitogen responses and suppressor
phenomena. J. Immunol. 134:1397-1402, 1985.
9. Maier T, Holda JH, Claman HN, Graft-versus-host reactions (GVHR) across
minor murine histocompatibility barriers. II. Development of natural suppressor cell
activity. J. Immunol.135:1644-1651, 1985.
10. Maier T, Holda JH, Claman HN, Synergism between T and non-T cells in the in
vivo induction and in vitro expression of graft-versus-host disease induced natural
suppressor cells. J. Exp. Med. 162:979-992, 1985
11. Holda JH, Maier T, Claman HN, Natural suppressor activity in graft-vs-host
spleen and normal bone marrow is augmented by IL-2 and interferon-gamma. J.
Immunol. 137:3538-3543, 1986
12. Maier T, Holda JH, Natural suppressor (NS) activity in neonatal spleen is
responsive to IFN-g. J. Immunol. 138:4075-4084, 1987.
13. Holda JH, Maier T, Claman HN, IFN-g is responsible for Natural Suppressor
activity in GVHD spleen and normal bone marrow. Transplantation, 45:772-777,
1988.
14. Lee Choi K, Maier T, Holda JH, Claman HN, Suppression of cytotoxic T-cell
generation by Natural Suppressor Cells from mice with GVHD is partially reversed
by indomethacin. Cellular Immunol. 112: 271-278, 1988.
15. Maier T, Holda JH, Claman HN, Murine natural suppressor (NS) cells in the
newborn, in bone marrow, and after cyclophosphamide: Genetic variations and
dependence on IFN-g. J. Immunol. 143: 491-498, 1989.
16. Holda JH, Maier T, Claman HN, IL-3, IL-4 and IL-6 enhance IFN-g dependent
bone marrow natural suppressor activity. Cellular Immunol. 125, 459-468, 1990.
17. Holda JH, LPS activation of bone marrow natural suppressor cells. Cellular
Immunol. 141, 518-527, 1992.
18. Haskins KA, Schlauder SM, Holda JH, Prednisolone inhibits LPS-induced bone
marrow suppressor cell activity in vitro but not in vivo. International Immunopharm.
3, 169-178, 2003.
19. White AM, Holda JH, Decreasing endogenous glucocorticoids alters the
ability of bone marrow cells to produce nitric oxide in response to
stimulating agents. Cellular Immunol. 232, 32-37; 2004,
20. Ditto AJ., Rheo JJ., Shaw, KN., Smolen JA., Holda JH., Ramirez RJ. YY Yung.
In Vivo Gene Delivery with L-Tyrosine Polyphosphate Nanoparticles. Mol.
Pharmaceutics. 10, 1836-1844; 2013.
Unrefereed Articles:
1. Swanborg RH, Holda JH: Suppressor cell regulation of experimental autoimmune
encephalomyelitis. In immunoregulation and autoimmunity. RS Krakauer, ed.,
Elsevier North-Holland, Inc., New York, 1980.
2. Swanborg RH, Holda JH, Killen JA: Immune regulation of autoimmune
encephalomyelitis. In proteins of the biological fluids. H. Peeters, ed., Pergamon
Press, Oxford, Vol. 30:179-182 1983.
3. Holda JH, Maier T, Claman HN: Murine graft-vs-host disease across minor
barriers; Immunosuppressive aspects of natural suppressor cells. Immunol. Rev.
88:87-105, 1985.
4. Maier T, Holda JH, Claman HN: Natural suppressor cells (NS): A member of the
LGL regulatory family. Immunol. Today 7:312-315,1986.
5. Claman HN, Holda J, Maier T: Natural suppressor cell systems. In Progress in
Immunology VI. B. Cinader and R.G. Miller, Eds. Academic Press, Orlando. pp
1035, 1986.
6. Maier T, Holda JH, Claman HN: Natural suppressor cells. In Immunity to
Cancer. M.S. Mitchell and C. Kirby Eds. Alan R. Liss, Inc. New York. p235-244,
1988.
7. Claman HN, Holda JH, Maier T, Choi KL: Chronic graft-vs-host disease:
Changes in natural suppressor cells. Israel J. of Medical Sci. 24: 367-371, 1988.
8. Maier T, Holda JH, Claman HN: Characterization and function of natural
suppressor systems. In Function Of The Natural Immune System. C.W. Reynolds
and R.H. Wiltrout, Editors. Plenum, New York. p267-297, 1989.