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Experimental Scheme Aim 1 mRNA Array miRNA Array Proteomics Phosphoproteomics EBOV IAV Lipidomics Metabolomics WNV PPIs Available MERS-CoV Cells Mice DMRD OMICs Samples Virological Data EBOV PPI Validation PML/ ArrayStar CMC Target Gene Predictions Differential Regulation Mechanistic Studies Comparison Among Viruses Select in vivo Targets Generate/Acquire KO Mice Phenotype/Virulence Iterative OMICs Aim 2 Virological Data OMICs Data