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A. Freedom from composite events (death, myocardial infarction, stroke, and progression to congestive heart failure) according to METS; reproduced with permission from Naji P, Griffin BP, Asfahan F, et al. Predictors of long-term outcomes in patients with significant myxomatous mitral regurgitation undergoing exercise echocardiography. Circulation. 2014 Mar 25;129(12):1310-1319. B. Cardiovascular death according to left ventricular ejection index; reproduced with permission from Magne J, Szymanski C, Fournier A, et al. Clinical and prognostic impact of a new left ventricular ejection index in primary mitral regurgitation because of mitral valve prolapse. Circ Cardiovasc Imaging. 2015 Sep;8(9):e003036. C, D. Survival and event-free survival according to leaft atrial dimensions or degree of dilatation; reproduced with permission from Rusinaru D, Tribouilloy C, Grigioni F, et al. Left atrial size is a potent Source: DEGENERATIVE MITRAL VALVE DISEASE, Hurst's The Heart, 14e predictor of mortality in mitral regurgitation due to flail leaflets: Results from a large international multicenter study. Circ Cardiovasc Imaging. 2011 Citation: Fuster V, Harrington RA, Narula J, Eapen ZJ. The Heart, 14e; 2017 cardiac Available at: http://mhmedical.com/ Accessed: Maycardiac 12, Sep;4(5):473-481; Athanasopoulos LV, McGurk S, Khalpey Z, et al.Hurst's Usefulness of preoperative dimensions to predict success of reverse 2017 remodeling in patients undergoing repair for mitral valve prolapse. Am J Cardiol. 2014 Mar 15;113(6):1006-1010. Copyright © 2017 McGraw-Hill Education. All rights reserved