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Signals from glial cells promote synapse formation. A. Astrocytes promote the maturation of both pre- and postsynaptic elements of the synapse.
B. Neurons cultured with astrocytes form more synapses, as assessed by expression of synaptic proteins (yellow dots). (Reproduced, with permission,
from Ben A. Barres.)
C. Retinal neurons cultured with astrocytes form a greater number of synapses, as shown by increased transmitter release.
D. Synapse formation is enhanced in the presence of astrocytes by three measures.
Source: Formation and Elimination of Synapses, Principles of Neural Science, Fifth Editon
Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available
at: http://mhmedical.com/ Accessed: May 12, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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