Download 10. Research and Reports in Focused Ultrasound

BRIEF CURRICULUM VITAE (09-15-2013)
Name:
Jeon-Hor Chen, M.D.
Titles/Affiliations:
1. Associate Researcher (equivalent to Associate Professor), Center for
Functional Onco-Imaging, University of California Irvine, California, USA
2. Honorary Professor, Department of Radiology, Eda Hospital and I-Shou
University, Kaoshiung, Taiwan
Address:
Center for Functional Onco-Imaging,
University of California Irvine,
No 164, Irvine Hall, CA 92697
Telephone:
949-8249327
Fax:
949-8243481
e-mail:
[email protected]
A. Education
Year
1979-1986
Institution
Degree
National Yang-Ming Medical University, Taipei, TAIWAN.
M.D.
B. Professional Experience
1984.7-1986.6
Medical Internship, Veteran General Hospital, Taipei, Taiwan.
1986.9-1988.8
Military Service, Lieutenant Officer
1
1988.9 – 1993.8
Resident and Fellow, Department of Radiology, Taichung Veterans General
Hospital
1993 ~ 1998
Staff Physician, Department of Radiology, Taichung VGH
1995~1996
Visiting scholar in Department of Radiology, Hospital of University of
Technology in Aachen, (10 months), Department of Radiology, Hospital of
University of Bonn, (2 weeks), Department of Radiology, Hospital of University
of Tubingen, (1 week), and Department of Radiology, Hospital of University of
Berlin, Germany (2 weeks)
1999 ~ 2002
Assistant Professor of Diagnostic Radiology and Institute of Medical
Research, China Medical University, Taichung, Taiwan
1998 ~ 2003
Staff Physician, Department of Radiology, China Medical College Hospital,
1999 ~ 2005
Head, Department of Radiology, China Medical University, Taichung, Taiwan
2003 ~ 2005
Chief, Section of GI Radiology, Department of Radiology, China Medical
College Hospital, Taichung, Taiwan
2003 ~ 2007
Associate Professor of Diagnostic Radiology and Institute of Medical
Research, China Medical University, Taichung, Taiwan
1999 ~ 2005
Executive Editor, Mid-Taiwan Journal of Medicine, Taichung, Taiwan
2005 ~ 2007
Visiting Associate Researcher, Center for Functional Onco-Imaging,
University of California Irvine, California, USA
2008 ~ 2012
Professor of Diagnostic Radiology and Institute of Medical Research,
China Medical University, Taichung, Taiwan
2009-2011
Chief, Section of Medical Imaging Research, Department of Radiology, China
Medical College Hospital, Taichung, Taiwan
2008 ~ present
Associate Researcher (equivalent to Associate Professor), Center for Functional
Onco-Imaging, University of California Irvine, California, USA
2013 ~ present
Honorary Professor, Department of Radiology, Eda Hospital and I-Shou
University, Kaoshiung, Taiwan
C. Honors and Awards
2001
Fellowship Grant, Research and Education Fund, European Congress of Radiology,
2
Vienna, Austria
2004 Physician Scientist Award, National Health Research Institute (NHRI), Taiwan
2008 Faculty development award, Department of Radiology, UC Irvine Medical Center
2008 Distinguished Researcher Award, China Medical University, Taichung, Taiwan
-2011
D. Ongoing Grant Supports
NIH/NCI 1 R01 CA127927 (Co-investigator)
04/01/13 – 03/31/18
Predicting Neoadjuvant Chemo Response/Prognosis Using Imaging Biomarkers
This study will use MRI and SMM markers to investigate and compare the response of patients with
breast cancer to neoadjuvant chemotherapy. The diagnostic results obtained using MRI and SMM
from tumors of varying stages at different times during NAC will provide very important
information for establishing the role of a standalone SMM system for management of breast cancer,
including screening and diagnosis.
NIH/NCI R21 CA170955 (Principal investigator)
01/01/2013 – 12/31/2014
Volume and Morphology of Fibroglandular Tissue for Breast Cancer Risk Prediction
This study will evaluate the role of MRI-based density parameters, including the volume and the
morphology of the fibroglandular tissue, and build a risk prediction model using a case-control
study design.
101-2314-B-039-034- (Principal investigator)
National Science Council (NSC), Taiwan
Multi-Modalities Quantitative Imaging Study of the Breast
08/01/12 – 10/31/13
E. Professional Activities
Society membership: 1. Radiological Society of North America (RSNA)
2. International Society of Magnetic Resonance in Medicine (ISMRM)
3. European Society of Radiology (ESR)
4. Radiological Society of Republic of China (RSROC)
Editorial Board: 1. Advances in Breast Cancer Research
3
2. Experimental Hematology and Oncology
3. Modern Chemotherapy
4. Journal of Computational Medicine
5. OA Translational Research
6. Journal of Radiology & Radiation Therapy
7. Radiology: Open Access
8. International Scholarly Research Network (ISRN) Radiology
9. The Journal of Radiology Case Reports
10. Research and Reports in Focused Ultrasound
Referee
NIH/NCI (USA); Annals of Oncology; Cancer; Neoplasia; Breast Cancer Research and Treatment;
British J Cancer; BMC Cancer; PloS One; Molecular Imaging and Biology; Journal of the
American Medical Informatics Association, NMR in Biomedicine; ISMRM; J. Magnetic
Resonance Imaging; European Radiology; European Journal of Radiology; Clinical Medicine:
Oncology; BMC Medical Imaging; Mid-Taiwan Journal of Medicine; Chinese Journal of
Radiology; National Science Council, Taiwan; Willy Gepts Research Foundation (UZ
Brussel),The Journal of Diabetes and Its Complications; Frontier in Medicine; Journal of
Radiology Case Reports; Radiology Open Access; Modern Chemotherapy
F. Publications:
Original Peer-Reviewed Articles:
***Total impact factor score for papers of first author and corresponding author in recent 5
years: >120
115. Chen JH, Yu H, Lin M, Mehta RS, Su MY. Background parenchymal enhancement in the
contralateral normal breast of patients undergoing neoadjuvant chemotherapy measured by
DCE-MRI. Magn Reson Imaging. 2013 Aug 28.
114. Yang MC, Moon WK, Wang YC, Bae MS, Huang CS, Chen JH, Chang RF. Robust Texture
Analysis Using Multi-resolution Gray-scale Invariant Features for Breast Sonographic Tumor
Diagnosis. IEEE Trans Med Imaging. 2013 Aug 29. [Epub ahead of print]
113. Chen JH, Su MY. Clinical application of magnetic resonance imaging in management of
breast cancer patients receiving neoadjuvant chemotherapy. Biomed Res Int.
2013;2013:348167.
112. Chen JH, Pan WF, Kao J, Lu J, Chen LK, Kuo CC, Chang CK, Chen WP, McLaren CE, Bahri
S, Mehta RS, Su MY. Effect of Taxane-Based Neoadjuvant Chemotherapy on Fibroglandular
4
Tissue Volume and Percent Breast Density in the Contralateral Normal Breast: Evaluated at 3T
MR. NMR in Biomedicine. 2013 Aug 12.
111. Moon WK, Lo CM, Cho N, Chang JM, Huang CS, Chen JH, Chang RF. Computer-aided
diagnosis of breast masses using quantified BI-RADS findings. Comput Methods Programs
Biomed. 2013 Jul;111(1):84-92.
110. Liao YH, Lo YP, Chen JH*. Small cardiogastric tube fistula connecting to right atrium. The
American Journal of Gastroenterology. Am J Gastroenterol 2013; 108:1398
109. Chen JH*, Chen WP, Chan S, Yeh DC, Su MY, McLaren CE. Correlation of Endogenous
Hormonal Levels, Fibroglandular Tissue Volume and Percent Density Measured Using 3D
MRI during one Menstrual Cycle. Annals of Oncology. Ann Oncol. 2013;24(9):2329-35.
108. Moon WK, Lo CM, Chang JM, Huang CS, Chen JH, Chang RF. Quantitative Ultrasound
Analysis for Classification of BI-RADS Category 3 Breast Masses. J Digit Imaging. 2013 Mar
15. [Epub ahead of print]
107. O'Sullivan TD, Leproux A, Chen JH, Bahri S, Matlock A, Roblyer D, McLaren CE, Chen
WP, Cerussi AE, Su MY, Tromberg BJ. Optical imaging correlates with magnetic resonance
imaging breast density and reveals composition changes during neoadjuvant chemotherapy.
Breast Cancer Res. 2013 Feb 22;15(1):R14. [Epub ahead of print]
106. Huang YH, Chen JH, Chang YC, Huang CS, Moon WK, Kuo WJ, Lai KJ, Chang RF.
Diagnosis of Solid Breast Tumors Using Vessel Analysis in Three-Dimensional Power
Doppler Ultrasound Images. J Digit Imaging. 2013 Aug;26(4):731-9.
105. Ho CY, Liao HM, Tu CY, Huang CY, Shih CM, Su MY, Chen JH*, Shih TC. Numerical
analysis of airflow alteration in central airways following tracheobronchial stent placement.
Exp Hematol Oncol. 2012 Aug 27;1(1):23.
104. Lin WC, Chen JH, Liao YS, Ho YJ. CT image in determining the need of TAE for
management of blunt renal injury. J Trauma and Acute Care Surgery 2013 Jan;74(1):230-5.
103. Moon WK, Huang CS, Chen JH, Chang RF. Computer-aided Tumor Detection Based on
Multi-scale Blob Detection Algorithm in Automated Breast Ultrasound Images. IEEE
Transactions on Medical Imaging 2013 Jul;32(7):1191-200.
102. Chen JH, Chan S, Yeh DC, Fwu, PT, Lin M, Min-Ying Su MY. Response of Bilateral Breasts
to the Endogenous Hormonal Fluctuation in A Menstrual Cycle Evaluated Using 3D MRI.
Magnetic Resonance Imaging 2013 May;31(4):538-44.
101. Moon WK, Lo CM, Chang JM, Huang CS, Chen JH, Chang RF. Computer-aided
classification of breast masses using speckle features of automated breast ultrasound images.
Med Phys. 2012 Oct;39(10):6465-73.
100. Yang MC, Huang CS, Chen JH, Chang RF. Whole Breast Lesion Detection Using NaiveBayes
Classifier for Portable Ultrasound. Ultrasound Med Biol. Ultrasound Med Biol. 2012
Nov;38(11):1870-80.
99. Chen JH , Chan S, Liu YJ, Yeh DC, Chang CK, Chen LK, Pan WF, Kuo CC, Lin M,
Chang D HE, Fwu PT, Su MY. Consistency of Breast Density Measured from the
Same Women in Four Different MR Scanners. Medical Physics. 2012
Aug;39(8):4886-95.
98. Moon WK, Lo CM, Huang CS, Chen JH, Chang RF. Computer-aided diagnosis based on
speckle patterns in ultrasound images. Ultrasound Med Biol. 2012 Jul;38(7):1251-61.
5
97. Kuzucan A, Chen JH*, Bahri S, Mehta RS, Carpenter PM, Fwu PT, Yu HJ, Hsiang DJ, Lane
KT, Butler JA, Feig SA, Su MY. Diagnostic performance of magnetic resonance imaging for
assessing tumor response in patients with HER2-negative breast cancer receiving neoadjuvant
chemotherapy is associated with molecular biomarker profile. Clin Breast Cancer. 2012
Apr;12(2):110-8.
96. Cheng YC, Wu NY, Ko JS, Lin PW, Lin WC, Juang SJ, Tsai TT, Chang CY, Chen JH*, Cheng
HC. Breast cancers detected by breast MRI screening and ultrasound in asymptomatic Asian
women: 8 years of experience in Taiwan. Oncology. 2012;82(2):98-107.
95. Chang YC, Huang YH, Huang CS, Chang PK, Chen JH*, and Chang RF. Classification of
breast mass lesions using model-based analysis of the characteristic kinetic curve derived from
fuzzy c-means clustering. Magnetic Resonance Imaging. 2012 Apr;30(3):312-22.
94. Chan S, Chen JH, Agrawal G, Lin M, Mehta RS, Carpenter PM, Nalcioglu O, Su MY.
Characterization of Pure Ductal Carcinoma In Situ on Dynamic Contrast-Enhanced MR
Imaging: Do Nonhigh Grade and High Grade Show Different Imaging Features?
J Oncol. J Oncol. 2010;2010. Epub 2010 Sep 21.
93. Chang DHE, Chen JH*, Lin MQ, Bahri S, Yu HJ, Mehta RS, Nie K, Hsiang D, Nalcioglu O,
Su MY. Comparison of breast density measured on MR images acquired using fat-suppressed
versus non-fat-suppressed sequences. Medical Physics. 2011;38(11):5961-8.
92. Chen JH, Chan S, Chang DHE, Lin MQ, Su MY. Consistency of Breast Density
Measured
from the Same Women Using Different MR Scanners. Annals of Oncology. 2011
Dec;22(12):2693-4.
91. Lin MQ, Chen JH, Mehta RS, Bahri S, Chan SW, Nalcioglu O, Su MY. Spatial
Shrinkage/Expansion Patterns between Breast Density Measured in Two MRI Scans
Evaluated by Non-rigid Registration. Physics in Medicine and Biology. 2011;56(18):5865-75.
90. Chen JH, Bahri S, Mehta RS, et al. Evaluation of Breast Cancer Response to Neoadjuvant
Chemotherapy Using Breast MRI at 3T. Radiology 2011 261(3):735-43.
89. Chan SW, Su MY, Lei FJ, Wu JP, Lin MQ, Nalcioglu O, Stephen F, Chen JH*. Menstrual
cycle related fluctations in breast density measured by 3D MRI. Radiology.
2011;261(3):744-51.
88. Moon WK, Shen YW, Huang CS, Luo SC, Chen JH* , Chang RF. Comparative Study of Density
Analysis Using Automated Whole Breast Ultrasound and MRI. Medical Physics. 2011
Jan;38(1):382-9.
87. Lin M, Chan S, Chen JH, Chang D, Nie K, Chen ST, Lin CJ, Shih TC, Orhan Nalcioglu O, Su
MY. A New Bias Field Correction Method Combining N3 and FCM for Improved
Segmentation of Breast Density on MRI. Medical Physics. 2011;38(1):5-14
86. J-H. Chen, R. S. Mehta, H-M. Baek, K. Nie, H. Liu, MQ Lin, H. J. Yu, O. Nalcioglu, M-Y. Su.
Clinical characteristics and biomarkers of breast cancer associated with choline
concentration measured by 1H MR spectroscopy. NMR Biomed. 2011;24(3):316-24.
85. JH Chen, YC Chang, D Chang, YT Wang, K Nie, RF Chang, O Nalcioglu, CS Huang,
MY Su. Reduction of Breast Density Following Tamoxifen Treatment Evaluated by 3-D
MRI: Preliminary Study. Magnetic Resonance Imaging. 2011 Jan;29(1):91-8.
84. Nie K, Su MY, Chau MK, Chan S, Nguyen H, Tseng T, Huang Y, McLaren CE, Nalcioglu O,
Chen JH. Age- and race-dependence of the fibroglandular breast density analyzed on 3D MRI.
Med Phys. 2010 Jun;37(6):2770-6.
6
83. Shih TC, Chen JH, Liu DX, Nie K, Sun LZ, Lin MQ, Chang D, Nalcioglu O, Su MY.
Computational Simulation of Breast Compression Based on Segmented Breast and
Fibroglandular Tissues on Magnetic Resonance Images. Physics in Medicine and Biology.
2010 Jul 21;55(14):4153-68.
82. Chen JH, Mehta RS, Nalcioglu O, Su MY. MR imaging evaluation of
non-inflammatory breast cancer with skin involvement following neoadjuvant
chemotherapy. Annuals of Surgical Oncology. 2010 Jul;17(7):1964-5.
81. Chang RF, Chang-Chien KC, Takada E, Huang CS, Chou YH, Kuo CM, Chen JH. Rapid
Image Stitching and Computer-aided Detection for Multi-pass Automated Breast
Ultrasound. Medical Physics. 2010 May;37(5):2063-73.
80. Nie K, Chen JH, Chang D, Hsu CC, Nalcioglu O, Su MY. Quantitative Analysis of Breast
Parenchymal Patterns Using 3D Fibroglandular Tissue Segmentation Based on MRI.
Medical Physics 2010;37(1):217-226
79. Nie K, Chang D, Chen JH, Hsu CC, Shih TC, Nalcioglu O, Su MY. Segmentation of Skin
for Quantitative Measurement of Breast Density on MRI. Medical Physics
2010;37(1):227-233
77. Chen JH, Nie K, Bahri S, Hsu CC, Hsu FT, Shih HN, Lin MQ, Nalcioglu O, Su MY. MRI
Evaluation of Decrease of Breast Density in the Contralateral Normal Breast of Patients
Receiving Neoadjuvant Chemotherapy. Radiology 2010 Apr;255(1):44-52.
76. Baek HM, Chen JH, Nalcioglu O, Su MY. Can MR Spectroscopy Provide Useful
Information for Characterizing Estrogen Receptor Status in Breast Cancer? In press,
Annals of Oncology 2010 Mar;21(3):663-5.
75. Lin M, Chen JH, Ni K, Chang D, Nalcioglu O, Su MY. An Algorithm-Based Method for
the Detection of Blood Vessels in Breast MRI for the Development of Computer-Aided
Diagnosis. JMRI Oct;30(4):817-24.
74. Chen JH, Huang CS, Chang Chien KC, Takada E, Moon WK, Wu JHK, Cho N, Wang YF,
Chang RF. Breast Density Analysis for Whole Breast Ultrasound Images. Medical Physics
2009 Nov;36(11):4933-43.
73. Newell D, Nie K, Chen JH, Hsu CC, Yu HJ, Nalcioglu O, Su MY. Selection of Diagnostic
Features to Differentiate between Malignant and Benign Lesions that Presented as Mass
and Non-Mass Lesions on Breast MRI. European Radiology 2010 Apr;20(4):771-81.
72. Chen JH, Chang D, Nie K, Hsu FT, Shih HN, Shu CC, Nalcioglu O, Su MY. Comparison
of Breast Density in the Contralateral Normal Breast of Patients with Invasive and In-Situ
Breast Cancer Measured on MRI. Annals of Oncology 2009 Aug;20(8):1449-50.
71. Chen JH, Hsu FT, Shih HN, Hsu CC, Chang D, Nie K, Nalcioglu O, Su MY. Does Breast
Density Show Difference in Patients with Estrogen Receptor Positive and Estrogen Receptor
Negative Breast Cancer Measured on MRI ? Annals of Oncology 2009 Aug;20(8):1447-9.
70. Lin CH, Chen JH, Li TC, Ho YJ, Lin WC. Children presenting at the emergency
department with right lower abdominal pain. Kaohsiung J Med Sci 2009;25:1–9
69. Lin WC, Chen YF, Lin CH, Ho YJ, Tzeng YH, Chiang HJ, Chang CH, Cheng YC, Shen
WC, Chen JH. Reappraisal of the management and outcome of emphysematous
pyelonephritis. Kaohsiung J Med Sci 2009;25:16–24
68. Bahri S, Chen JH, Mehta RS, Carpenter PM, Nie K, Kwon SY, Yu HJ, Nalcioglu O, Su
MY. Residual Breast Cancer Diagnosed by MRI in Patients Receiving Neoadjuvant
7
Chemotherapy with and without Bevacizumab. Annals of Surgical Oncology 2009
Jun;16(6):1619-28.
67. Lai HY, Chen JH, Chiu KM, Wan KL, Cheung WK, Li AH, Chu SH. CT imaging of two
hearts beat in one chest. AJR 2008 Dec;191(6):1711-6
66. Chen JH, Mehta RS, Nalcioglu O, Su MY. Inflammatory Breast Cancer Following
Neoadjuvant Chemotherapy: Can MR Imaging Precisely Diagnose the Pathological Response?
Annals of Surgical Oncology 2008 Dec;15(12):3609-13.
65. Agrawal G, Su MY, Nalcioglu O, Stephen F, Chen JH. Significance of Breast Lesion
Descriptors in the ACR BIRADS MRI Lexicon. Cancer 2009 Apr 1;115(7):1363-80.
64. Nie K, Chen JH, Chan S, Chau MK, Yu HJ, Bahri, S, Tseng T, Nalcioglu O, Su MY.
Development of A Quantitative Method for Analysis of Breast Density Based on 3-Dimensional
Breast MRI. Medical Physics 2008:35(12):5253-62.
63. Chen JH, Feig BA, Hsiang JB, Butler JA, Mehta RS, Bahri S, Nalcioglu O, Su MY. Impact of
MRI-Evaluated Neoadjuvant Chemotherapy Response on Change of Surgical Recommendation
in Breast Cancer. Annals of Surgery 2009 Mar;249(3):448-54.
62. Baek HM, Chen JH, Nie K, Yu HJ, Bahri S, Mehta RS, Nalcioglu O, Su MY. Predicting
Pathological Response to Neoadjuvant Chemotherapy in Breast Cancer Using MRI and
Quantitative Proton MR Spectroscopy. Radiology 2009 Jun;251(3):653-62.
61. Nie K, Chen JH, Yu HJ, Chu Y, Nalcioglu O, Su MY. Quantitative Analysis of Lesion
Morphology and Texture Features for Diagnostic Prediction in Breast MRI. Academic
Radiology 2008 Dec;15(12):1513-25..
60. Chen JH, Naclioglu O, Su MY. Fibrocystic change presenting as a focal lesion mimicking
breast cancer. JMRI 2008 Dec;28(6):1499-505.
59. Chen JH, Liu H, Baek, HM, Nalcioglu O, Su MY. MR imaging of fibrocystic change of the
breast. Magnetic Resonance Imaging 2008 Nov;26(9):1207-14.
60. Ho TJ, Duann JR, Chen CM, Chen JH, Shen WC, Lu, TW, Liao JR, Lin JG. Carryover effects
alter FMRI statistical analysis in an acupuncture study. Am J Chin Med. 2008;36 (1):55-70
57. Baek HM, Chen JH, Naclioglu O, Su MY. Proton MR spectroscopy for monitoring early
treatment response of breast cancer to neoadjuvant chemotherapy. Annals of Oncology Ann
Oncol. 2008 May;19(5):1022-4.
56. Chen JH, Nalcioglu O, Su MY. MR imaging of invasive breast cancer correlated with
hormonal receptors: Does progesterone receptor matter ? Annals of Oncology 2008
May;19(5):1024-6.
55. Lin WC, Chen YF, Lin CH, Tzeng YH, Chiang HJ, Ho YJ, Shen WC, Chen JH. Emergent
transcatheter arterial embolization in hemodynamically unstable patients with blunt splenic
injury. Academic Radiology 2008;15(2):201-208
54. Bahri S, Chen JH, Yu HJ, Kuzucan A, Nalcioglu O, Su MY. Can Dynamic Contrast-Enhanced
MRI (DCE-MRI) Predict tumor recurrence and lymph node status in patients with breast
cancer? Annals of Oncology. 2008 Apr;19(4):822-4.
53. Baik HM, Chen JH, Nalcioglu O, Su MY. Choline as a biomarker for cell proliferation: do the
results from proton MR spectroscopy show difference between HER2/neu positive and negative
breast cancers? International J Cancer 2008 Sep;123(5):1219-21.
52. Chen JH, Baik HM, Nalcioglu O, Su MY. Estrogen receptor and breast MR imaging features:
a correlation study. JMRI 2008 Apr;27(4):825-33
8
51. Baik HM, Yu HJ, Chen JH, Nalcioglu O, Su MY. Correlation between choline and contrast
enhancement in human breast cancer measured by quantitative 1H single-voxel MR
spectroscopy and dynamic contrast enhanced MRI. Magnetic Resonance Imaging, 2008
May;26(4):523-31.
50. Agrawal G, Chen JH, Baik HM, Hsiang D, Mehta RS, Nalcioglu O, Su MY. MR imaging
features of breast cancer: a correlation study with HER-2 receptor. Annals of Oncology, 2007
Nov;18(11):1903-4.
49. Chen JH, Mehta RS, Carpenter PM, Nalcioglu O, Su MY. MRI in predicting pathological
response of triple negative breast cancer following neoadjuvant chemotherapy. J Clin Oncol.
2007 Dec 10;25(35):5667-9
48. Chen JH, Agrawal G, Feig, B, Baik HM, Carpenter PM, Nalcioglu O, Su MY. Triple negative
breast
cancer: MR imaging features in 29 patients. Annals of Oncology, 2007
Dec;18(12):2042-3
47. Chen JH, Agrawal G, Carpenter PM, Mehta RS, Nalcioglu O, Su MY. Pathological axillary
lymph node status in HER-2 receptor positive and negative breast cancers. Annals of Surgical
Oncology, 2008 Mar;15(3):941-2
46. Chen JH, Feig B, Agrawal G, Yu H, Carpenter PM, Mehta PS, Nalcioglu O, Su MY. MRI
evaluation of pathological complete response and residual tumors in breast cancer following
neoadjuvant chemotherapy. Cancer. 2008;112:17-26
45. Lin WC, Chen JH. Urinary bladder metastasis from breast cancer with heterogeneic expression
of estrogen and progesterone receptors. Journal of Clinical Oncology. 2007 September 20;
25(27):4308 - 4310
44. Lin WC, Chen JH, Lin CH, Shen WC. Rapidly progressive pancreatic lipomatosis in a young
adult patient with transfusion-dependent myelodysplastic syndrome. J Formos Med Assoc.
2007 Aug;106(8):676-9.
43. Agrawal G, Chen JH, Baick CH, Chen A, Mehta RS, Nalcioglu O, Su MY. Pathological
complete response in triple negative poorly differentiated invasive ductal carcinoma detected
during pregnancy. Journal of Clinical Oncology. 2007; June 20 issue: 2618-2610
42. Yu H, Chen JH, Su MY, Mehta R, Nalcioglu O. MRI Measurements of Tumor Size and
Pharmacokinetic Parameters as Early Predictor of Response in Breast Cancer Patients
Undergoing Neoadjuvant AC-Chemotherapy. JMRI. 2007 Sep;26(3):615-23.
41. Baik HM,Chen JH, Su MY, Yu H, Mehta R, Nalcioglu O. Characterization of Human Breast
Lesions with in Vivo MR Chemical-Shift Imaging. JMRI, 2008 May;27(5):1114-21
40. Su MY, Baik HM, Yu HJ, Chen JH, Mehta RS, Nalcioglu O. Comparison of Choline and
Pharmacokinetic Parameters in Breast Cancer Measured by MR Spectroscopic Imaging and
Dynamic Contrast Enhanced MRI. Technology in Cancer Res Treat. 2006;5:401-410.
39. Huang YL, Chen JH, Shen WC. Diagnosis of hepatic tumors with texture analysis in
nonenhanced computed tomography images. Acad Radiol. 2006 Jun; 13(6):713-20.
35. Lin YC, Chen JH, Han KW, Shen WC. Ablation of Liver Tumor by Injection of Hypertonic
Saline. Am. J. Roentgenol., Jan 2005; 184: 212 - 219.
32. Chen JH, Lin YC, Shen WJ. Implantation of VX2 tumor in rabbit liver: comparison of two
inoculation methods. Lab Anim. 2004 Jan; 38(1):79-84.
9
30. Pan CT, Chou KJ, Chen JH, Jian IP, Lin JI, Tsai JH. Safety monitoring of cardiac and hepatic
systems in -thalassemia patients with chelating treatment in Taiwan. Eur J. Haematol 2003
(June); 70:392-397
27. Lin WY, Chen JH, Lin YC, Han KW. Implantation of VX2 carcinoma into the liver of rabbits:
a comparison of three direct-injection methods. J. Vet. Med. Sci. 2002; 64(7):649-652
26. Tsai JW, Chen JH, Chiang JM. SPGR as an arterial spin tagging technique for quick
evaluation of local perfusion. JMRI 2002; 16: 51-59
24. Chen JH, Chai JW, Chu WC, Chiang JM, Shen WC. Free breathing Magnetic Resonance
Cholangiopancreatography (MRCP) at end expiration: a new technique to expand clinical
application. Hepato-Gastroenterology 2002; 49:593-596
23. Tsai PP, Chen JH, Huang JL, Shen WC. Dependent Pooling: A Contrast-Enhanced Sign of
Cardiac Arrest During CT. Am. J. Roentgenol., May 2002; 178: 1095 - 1099.
22. Chai JW, Lin JC, Chen JH, Wu JC, Lee GP, Chu WC, Lee SK. In vivo Magnetic Resonance
(MR) study of fatty liver: importance of intracellular ultrastructural alteration for MR tissue
parameters change. Journal of Magnetic Resonance Imaging 2001; 14:35-41
17. Chen WP, Chen JH, Hwang JI, Tsai JW, Chen JS, Hung SW, Su YG, and Lee SK. Spectrum of
transient hepatic attenuation differences in biphasic helical CT. Am. J. Roentgenol., Feb 1999;
172: 419 - 424.
16. Chen JH, Chai JW, Huang CL, Hung HC, Shen WC, Lee SK. Proximal arterioportal shunting
associated with hepatocellular carcinoma: features revealed by dynamic helical CT. Am. J.
Roentgenol., Feb 1999; 172: 403 - 407.
15. Chen JH, Chai JW, Lee SK, Yang HN. Evaluation of liver diseases with magnetization transfer
and contrast agents. J Mag Reso Imag, 1999; 9(2):257-265
11. Chen JH, Chen WP, Hwang JL, Shen WC. Dynamic helical CT as a novel technique for
evaluating hepatic perfusion disorders. Hepatogastroenterology, 1999; 46(25):303-307
9. Chen JH, Hwang JH, Hwang JI, Lee SK, Shen WC. Dynamic helical biphasic CT emerges as a
potential technique for the diagnosis of proximal arterioportal shunting.
Hepatogastroenterology, 1999; 46(27): 1791-1797
8. Chen JH, Chai JW, Shen WC. Magnetization transfer contrast imaging of liver cirrhosis.
Hepatogastroenterology, 1999; 46(29):2872-2877
5. Chen JH, Katterbach FJ. Rotational phantom for evaluating MR biopsy needle artifacts. AJR
1997; 168:1383-1384
3. Chai JW, Chen CC, Chen JH, Lee SK, Yang HN. Estimation of in vivo proton intrinsic and
cross-relaxation rates in human brain. Magn Reson Med 1996; 36(1): 147-152
2. Urhahn R, Adam G, Busch N, Chen JH, Euringer W, Guenther RW. Superparamagnetische
eisenoxidpartikel: welchen stellenwert hat der T1-effekt fur die MR-diagnostik fokaler
leberlasionen. ROFO 1996; 165(4): 364-370 (in German)
10
Books
1. Jeon-Hor Chen. Gradient echo sequences and fast MR imaging technique. In Diagnostic MR
Imaging, published by Hwa-Jun publication company, 1989, Taipei
2. Jeon-Hor Chen. MRI of Great Vessels. In Diagnostic MR Imaging, published by Hwa-Jun
publication company, 1989, Taipei
3. Jeon-Hor Chen. Basic principle of MR imaging. In Biomagnetic material and related
technologies. Published by Society of Biomagnetic Material and Technology, 2003, Taipei
4. Jeon-Hor Chen. Quantitative Measurements of Tracer Transport Parameters Using Dynamic
Contrast-Enhanced MRI as Vascular Perfusion and Permeability Indices in Cancer Imaging. In
Quantifying Morphology and Physiology of the Human Body Using MRI. L . Tugan Muftuler.
Taylor & Francis 2013. Print ISBN: 978-1-4398-5265-1. eBook ISBN: 978-1-4398-5268-2
Peer-Reviewed Conference Papers: more than 100 presented in imaging, surgery, and oncology
conferences
Examples of 5 abstracts.
1. Chen, Jeon-Hor; Bahri, Shadfar; Carpenter, P.; Yu, H-J; Mehta, R.; Nalcioglu, Orhan; Su,
Min-Ying Lydia. Evaluation of Neoadjuvant Chemotherapy Response of Breast Cancer at 3.0T.
Presented at the Joint ISMRM-ESMRMB Meeting, Stockholm, Sweden, May 1-7, 2010; program
number 2472.
2. Chen, Jeon-Hor; Chang, Yeun-Chung; Chang, Daniel; Wang, Yi-Ting; Nie, Ke; Chang,
Ruey-Feng; Nalcioglu, Orhan; Huang, Chiun-Sheng; Su, Min-Ying Lydia. Reduction of Breast
Density Following Tamoxifen Treatment Evaluated by 3-D MRI. Presented at the Joint
ISMRM-ESMRMB Meeting, Stockholm, Sweden, May 1-7, 2010; program number 2473.
3. Chen, Jeon-Hor; Nie, Ke; Bahri, Shadfar; Mehta, Rita S.; Hsu, Chieh-Chih; Hsu, Fei-Ting; Shih,
Han-Ni; Lin, Muqing; Nalcioglu, Orhan; Su, Min-Ying Lydia. MRI Evaluation of Decrease of
Breast Density in the Contralateral Normal Breast of Patients Receiving Neoadjuvant
Chemotherapy. Presented at the Joint ISMRM-ESMRMB Meeting, Stockholm, Sweden, May 1-7,
2010; program number 2474.
4. Chen, J-H. The Association between Choline Concentration Measured by 1H MR Spectroscopy
with Clinical Characteristics and MR Imaging Features of Breast Cancer. Presented at 95th RSNA
annual meeting, Chicago, 2009, abstract number LL-BR4087-L02
5. Chen, Jeon-Hor; Hsu, F-T; Shih, H-N; Hsu, C-C; Chang, Daniel; Nie, K; Nalcioglu, Orhan; Su,
M-Y. Comparison of Breast Density in the Contralateral Normal Breast of Patients with Different
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Types of Breast Cancer Measured on MRI. in "Proc., 17th ISMRM Annual Meeting, Honolulu,
Hawaii, 2009" page 2230.
G. Invited Talks (Recent years)
1. Correlation of clinical characteristics and biomarkers with breast MRI/MRS. March 20, 2010.
Asian-Ocean Congress of Radiology 2010, Taipei, Taiwan. KeyNote Speaker.
2. Assessment of breast cancer risk: 3D MR-based breast density vs. mammographic density.
March 22, 2010. Asian-Ocean Congress of Radiology 2010, Taipei, Taiwan. KeyNote Speaker.
3. Prediction and monitoring of treatment response for breast cancer following neoadjuvant
chemotherapy: evaluated with breast MRI. March 22, 2010. Asian-Ocean Congress of
Radiology 2010, Taipei, Taiwan. KeyNote Speaker.
4. Response Evaluation of Breast Cancer Chemotherapy Using MR Imaging and Quantitative 1H
MR Spectroscopy. September 11, 2010. Shaping Future Cancer Medicine: The 1ST Samsung
Comprehensive Cancer Center Symposium, Seoul, Korea. KeyNote Speaker
5. Measurement of Breast Density and Correlation with Cancer Risk. September 10, 2010.
Department of Radiology, Samsung Medical Center, Seoul, Korea. Invited Talk.
6. Breast MR Imaging and MR Spectroscopic Choline Quantification: Correlated with Biomarkers
and Clinical Characteristics. September 10, 2010. Department of Radiology, Samsung Medical
Center, Seoul, Korea. Invited Talk.
7. Imaging Biomarkers: Hopes and Hurdles. March 20, 2011. Annual Meeting of the Radiological
Society of the Republic of China, Taichung, Taiwan. KeyNote Speaker.
8. Brief Review of Diagnosis and Management of Prostate Cancer. March 20, 2011. Annual
Meeting of the Radiological Society of the Republic of China, Taichung, Taiwan. KeyNote
Speaker.
9. Imaging Tumor Response: RECIST and Beyond. May 29, 2013. Department of Radiology,
Taichung Veterans General Hospital, Taichung, Taiwan.
10. Breast Imaging Beyond Mammography and Ultrasonography. October 22, 2013.
Radiological Society of Republic of China (RSROC), Kaoshiung, Taiwan. (to be delivered)
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