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1509 Oral or Poster ablation Cat: 47 Electrophysiologic techniques of mapping and radiofrequency AV NODE ABLATION AND CARDIAC RESYNCHRONIZATION THERAPY IN PATIENTS WITH PERMANENT ATRIAL FIBRILLATION M. Moghaddam1, N. Moghaddam2, B. Moghaddam3, A. Bagher Zadeh1 1. Jam Hospital, Tehran, Iran 2. UBC, Med School, Vancouver, BC, Canada 3. UoT, Med School, Toronto, Ont., Canada Objective : The aims of this study were : 1-assessing the clinical benefit of cardiac resynchronization therapy (CRT) in patients with atrial fibrillation (AF), 2- evaluating the impact of AV-Node (AV-N) ablation in outcome of AF patients undergoing CRT. Background: Heart failure (HF) predispose AF and AF can worsen HF , CRT is an important advance in treatment of end stage HF Method: A total of 68 permanent AF patients were included in this prospective study. 34 patients received optimized medical treatment controlling ventricular rate, and 34 patients underwent AV-N ablation and Biv pacing. Mean age was :58.3±18 year and NYHA class: II,III,IV : 29/51/18.Duration of fallow up was 21±11 months. Result: Clinical and echocardigraphic parameters were compared at baseline and 1 and every 6 month then after. Patients were evaluated for the occurrence of cardiac death, hospitalization for HF , and CRT responsiveness. LVEF and NYHA class was improved significantly in AV-N ablation group rather than in medical treatment group. Also cardiac death and hospitalization rate decreased in the first group. Conclusion: AF can worsen HF and vice versa. AV-N ablation and CRT in these patients who are non-responsive to medical treatment and are poor candidate for AF ablation is an acceptable treatment. Also by AV-N ablation Atrio Ventricular dysynchrony in AF is disappeared.