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X-ray Dx Study Guide for test 3 (Tumors) 1. Primary malignant tumor capable of producing a cannonball lesion Osteosarcoma 2. Most common mets in children 5 years old and younger Neuroblastoma 3. What is the process of lytic lesions? pressure erosion 4. Which tumor could show an unremarkable bone scan? Multiple Myeloma 5. Which primary Neoplasms will metastasize to the hand and foot? Bronchogenic Carcinoma 6. Bone expansion A) Primary malignancy 7. Effects joint spaces B) Secondary malignancy 8. Soft tissue C) Neither 9. Multiple lesions 10. >10 cm in length 11. Erodes bone in a few days 12. Periosteal response 13. Most common tumor that causes multiple levels of vertebral collapse Multiple Myeloma 14. A 65 yr. old male presents with sciatica, LBP, and intermittent pain which is becoming constant. Which is the most serious symptom? Nocturnal pain? or Post exercise hematuria? 15. If the same pt has multiple myeloma what would be a finding? Normochromic, normocytic anemia 16. What would be the confirmatory test for multiple myeloma? Immuno-electrophorhesis 17. If x-ray of the skull showed lytic lesions and a spiculated response, what would be the dx? Neuroblastoma 18. Which of the following is least likely to calcify? Fibrous, Cartilaginous, Osteoid, or they would all be the same? Fibrous 19. Originates in the abdomen A) Neuroblastoma 20. Shows "flocculent" pattern B) Chondrosarcoma 21. Uniform holes in the skull C) Multiple myeloma 22. Age 10-25, diaphysis D) Ewing's Sarcoma 23. Cortical Saucerization E) Osteosarcoma 24. Metaphysis of a 10-20 year old 25. Hot spots are a consequence of? Osteoblastic activity 26. If you see an ill defined pedicle on a film... Rule in lytic mets until proven otherwise 27. Heavy smoker presents with LBP what do you do first? Physical exam 28. If you treat this patient and he seems to improve which is true? Spinal adjustments decrease pain in cancer Bone scan may be indicated 29. If you do a bone aspiration what will you find in secondary lesions? Cells similar to those in the primary lesion 30. Which primary malignancy crosses the epiphyseal plate? Chondroma 31.What is the most common tumor to metastasize to other bone? Ewing's Sarcoma 32. Tumors don't spread readily though the lymph system because There is a lack of lymph channels in bone 33. What is the most reliable way to distinguish between mets and infection? Infection crosses the joint space 34. Blastic mets show? Reactive sclerosis 35. Which is associated with chondrosarcoma? A history of enchondroma 36. Which is least likely to show an increase in alkaline phosphatase? multiple myeloma 37. Which is more closely related to a secondary lesion than a primary lesion? No periosteal response?? 38. If Benz-Jones proteins are present this is ? inclusive of multiple myeloma 39.What is true of solitary plasmacytoma? 7 out of 10 develop multiple myeloma 40. Which is closely related to the knee and is found in the metaphysis? Osteosarcoma 41. What is the most common malignancy of the hand? Chondrosarcoma 42. Other than the mandible where is adamantioma found? Tibia 43. A patient presents with hematogenous dysuria. Which indicates prostate? acid phosphatase ring sclerosis Affects sinuses and vision 4th m/c primary malignant bone tumor Affects children under two fallen fragment sign saber shin deformity Primary that affects the ends of the axial skeleton, sacrococcygeal & sphenooccipital Fibrous dysplasia Osteo____ Ewing's sarcoma Neuroblastoma unicameral bone cyst Paget's Chordoma Generally affects Vertebral body Generally affects posterior motor units more Coast of Calif. smooth cafe au lait spots osteolysis, then repair second m/c primary malignant bone tumor Affects patients over 55 yrs of age 50% develop sharp kyphoscoliosis Quasi-malignant spoked wheel skull Osteoporosis circumscripta Corduroy cloth appearance ground glass appearance causes lytic mets 70% of malignancies of bone shepherd's crook deformity cotton wool M/C primary bone malignancy causes mixed mets cardiomegaly Many osteochondromas m/c benign tumor of the spine & (1% of all primary bone tumors) pain worse @ night relieved by aspirin Primary Malignancy Secondary malignancy mets is rare here Aggressive process = malignant soft tissue more round permeative motheaten imperceptable margins Epiphysis Neurofibromatosis Paget's Osteosarcoma Paget's Neurofibromatosis Giant-cell tumor hemangioma Paget's hemangioma fibrous dysplasia lung cancer metastasis fibrous dysplasia or Paget's Chondroblastoma or Paget's multiple myeloma breast cancer Paget's hereditary multiple exostosis hemangioma (vertebra & skull) osteoid osteoma <1cm & (Brodies abscess >1cm) below elbow or knee non-aggressive process = benign Chondroblastoma Giant Cell after fusion of growth plate Diaphysis Bone island Ewing's Sarcoma m/c cause of missing pedicles Round Cell tumors uncommon cause of ivory vertebra metaphysis (Classic) Causes of ivory vertebra Myeloma Ewing's sarcoma (classic) Non-Hodgkin's Lymphoma Adamantinoma enostoma Diaphyseal lesion onion skin cortical saucerization codman's triangle sunray/whiskers effect metastasizes early - to bone Lytic mets Ewing's sarcoma multiple myeloma Non-Hodgkin's Lymphoma Multiple Myeloma Osteosarcoma Paget's (55yrs cortical thickening, bone bigger) Hodgkin's Lymphoma (35 yrs) Osteoblasic Metastasis (55 yrs, regular outline, normal sized or collapsed)