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Striatal intrinsic plasticity and information processing
in the corticostriatal funnel
Cortical synchronization
Firing of striatal medium spiny neurons
+
Short-term intrinsic plasticity
Cortical requirements for striatal MS neuron firing
Cerebral cortex
Striatum
Intrinsic plasticity
Membrane constants of MS neurons are not constant
Vm
From Charlie Wilson
Experimental demonstration of a
need of cortical spatio-temporal synchrony
Desynchronized
Synchronized
Temporal and spatial contraction in the CS pathway
Cortical synchronization as a trigger for striatal intrinsic plasticity?
Spike-dependent increase in membrane excitability
A
C
B
D
Spike-dependent facilitation of cortical inputs
Effects on the corticostriatal input-output relationship
No change in synaptic strength
Decrease in spike threshold and latency
Role of the striatal K+ current IAS
Properties of IAS
Activation of outward
K+ current (IAs)
Slow recovery
from inactivation
(t ~ 300 ms)
In vitro experiments
Striatal intrinsic plasticity:
Changes in the cortical parameters effective for striatal neurons firing and
optimization of the information transfer in the corticostriatal pathway
Intrinsic plasticity
Séverine Mahon (University College of London)
Stéphane Charpier (INSERM U667 Collège de France)
Guilaume Casassus (UMR CNRS 5091Institut François Magendie)
Christophe Mulle (UMR CNRS 5091Institut François Magendie)