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Dr. Alice’s Anti-Angiogenesis Protocol: for Patients of Pawspice & Animal Oncology Consultation Service www.pawspice.com Alice Villalobos, DVM, Fellow Emeritus National Academies of Practice Introduction: Cancer cells accomplish their fatal agenda because they have uncontrollable growth and invade vital structures. One approach in the battle against cancer is to target common pathways. All types of cancers (sarcomas, carcinomas and adenocarcinomas) except blood cancers (leukemia and lymphoma) recruit capillaries and blood vessels to grow. The process is called angiogenesis. If we change the cancer microenvironment and reduce or cut off cancer’s recruitment of its blood supply (anti-angiogenesis), we can win more quality time. Anti-angiogenesis agents inhibit the growth of malignant cancer cells so they can’t form more tumor tissue. In a series of 600 animal patients, it was shown that 70% had responses with tumors becoming stable or reduced in size. We have put together a special combination of anti-angiogenesis agents (some holistic & some Rx’s) for the pets in our Pawspice & Animal Oncology practices and expect good results. We also use kinder gentler chemotherapy that is called “metronomic” chemotherapy (mCTx). It is the use of continuous daily low doses of chemotherapy which is proven to have anti-angiogenesis action. Dr. Alice’s Anti-Angiogenesis Protocol: For Cancer Patients Integrative Agents with 70% response in 600 animal patients 1) AngioStop (Sea Cucumber): ½ capsule per 60# 2-3 x daily 2) Asparagus Extract: ½ capsule per 60# 2-3 x daily 3) Revivin: ½ capsule per 60# once daily Rx’s with proven anti-cancer and anti-angiogenesis action 4) Metronomic Chemotherapy: low daily dose Rx for cancer type 5) NSAIDs aspirin type Rx: piroxicam or meloxicam (with Pepcid) 6) Metformin: an anti-diabetic drug with proven anti-cancer action Immuno-Nutrition Supplements: to improve the patient’s immune system, nutritional status, overall well being and quality of life. 7) 8) 9) 10) 11) Agaricus Bio: 600mg cap 2 x daily +/- Primal Dose Colostrum Onco Support: 1 scoop for dogs >50# 2 x daily IP-6: one capsule per 10-20 pounds 2 x daily Platinum Performance: slow start up to 1 TBS/60#/day Vitality: anti-aging: 1 cap/20# up to 3 AM & 3 by 2:00PM Cancer patients may need other Rx’s…and items from each category depending upon cancer type, condition and age of the patient. Items can be given separately, mixed in meals or blended into a liquid elixir and given orally 2-3 x a day as directed by Dr. Villalobos & staff.