Download Drug Information Sheet("Kusuri-no-Shiori") Internal Revised: 03

Drug Information Sheet("Kusuri-no-Shiori")
Internal
Revised: 03/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval
details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is
important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response,
patients should understand their medication and cooperate with the treatment.
Brand name:CONIEL Tablets 4
Active ingredient:Benidipine hydrochloride
Dosage form:yellow tablet, φ: 7.1 mm, thickness: 3.3 mm
Print on wrapping:KH209 4mg コニール
Effects of this medicine
When calcium flows into cells in vessels, the vessels constricts and the blood pressure increases. This medicine
blocks calcium inflow and consequently dilates constricted vessels to decrease blood pressure.
It also dilates vessels of the heart to prevent developing anginal attacks (chest pain which mostly occurs in the
heart).
It is usually used in the treatment of hypertension, renal parenchymal hypertension and angina pectoris.
Before using this medicine, be sure to tell your doctor and pharmacist
・If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are a patient with cardiac disease, hepatic disorder or hypotension.
・If you are pregnant, possibly pregnant, or breastfeeding.
・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal
effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
・Your dosing schedule prescribed by your doctor is<<
to be written by a healthcare professional>>
・For hypertension and renal parenchymal hypertension: In general, for adults, take 1/2 to 1 tablet (2 to 4 mg of the
active ingredient) at a time, once daily, after breakfast. The dosage may be adjusted according to age or
symptoms, however, if the effect is insufficient, it may be increased up to 2 tablets (8 mg) once daily. In severe
hypertension, take 1 to 2 tablets (4 to 8 mg) at a time, once daily, after breakfast.
For angina pectoris: In general, for adults, take 1 tablet (4 mg of the active ingredient) at a time, twice daily, after
breakfast and supper. The dosage may be adjusted according to age or symptoms.
In any case, strictly follow the instructions of your doctor/pharmacist.
・If you miss a dose, take a dose as soon as possible. After taking the medicine, wait about 8 hours for hypertension,
and about 5 hours for angina pectoris to take the next dose. DO NOT take double doses to make up for the missed
dose.
・If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
・Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
・The medicine may cause dizziness and lightheadedness due to blood pressure decreased. Be careful when you work
at heights, drive a car or operate dangerous machinery.
・Grapefruit juice may intensify the therapeutic effects of the medicine. Do not take the medicine with grapefruit
juice.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: palpitation,
facial flush, headache, hypersensitivity (rash, itch, photosensitivity), gynecomastia, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated
in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor
immediately.
・general malaise, loss of appetite, nausea, yellowing in skin and white of eyes [hepatic dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your
doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
・Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
・Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.
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For healthcare professional use only
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For further information, talk to your doctor or pharmacist.
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