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Transcript 
Histone Deacetylation Inhibition in Pulmonary
HypertensionClinical Perspective
by Lan Zhao, Chien-Nien Chen, Nabil Hajji, Eduardo Oliver, Emanuele Cotroneo,
John Wharton, Daren Wang, Min Li, Timothy A. McKinsey, Kurt R. Stenmark, and
Martin R. Wilkins
Circulation
Volume 126(4):455-467
July 24, 2012
Copyright © American Heart Association, Inc. All rights reserved.
Histone deacetylase (HDAC) protein expression levels in human lung extracts from idiopathic
pulmonary artery hypertension (IPAH) patients (n=12) and lobectomy patients (control; n=21).
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
Time course of development of pulmonary hypertension phenotype and histone deacetylase
(HDAC) expression in a chronically hypoxic rat.
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
Immunohistochemistry of HDAC1 and HDAC5 in human and rat lungs.
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
Treatment of established hypoxia-induced pulmonary hypertension.
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
Expression of Bcl-2, p21, and acetylated histone levels in rat lung extracts from the chronic
hypoxia treatment study.
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
Effects of histone deacetylase inhibition on bovine R-cells and adventitial fibroblasts (PH-Fibs)
in culture.
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
Effects of valproic acid (VPA; 5 mmol/L) and suberoylanilide hydroxamic acid (SAHA; 10 μmol/L)
on gene expression of growth factors (cKIT, PDGF-b, S100A4) and proinflammatory factors
(monocyte chemoattractant protein-1 [MCP-1], stromal-derived factor-1 [SDF-1], interleukin-6 ]IL6]) in serum-deprived R-cells.
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
Effect of histone deacetylase inhibition on platelet-derived growth factor (PDGF)–stimulated
human pulmonary smooth muscle cells in culture.
Lan Zhao et al. Circulation. 2012;126:455-467
Copyright © American Heart Association, Inc. All rights reserved.
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