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Melbourne Health Shared Pathology Service HDL Cholesterol (HDLC, high density lipoprotein cholesterol) See also Cholesterol, total; LDL cholesterol [LDLC]; lipid study. Specimen 5 ml blood, lithium-heparin or serum tube. Patient does not need to be fasting. Prolonged tourniquet use can artefactually increase levels by up to 20%. Test availability Reference interval plasma or serum adult Assayed daily. M F 0.7 – 1.9 mmol/L 0.9 – 2.4 mmol/L The National Heart Foundation recommends that total HDL-cholesterol in adults be at least 1.0 mmol/L. Uncertainty of measurement: CVa: RMH, 2.7% at 1.9 mmol/L. Clinical applications Assessment of lipid status, particularly as a risk factor for coronary artery disease. Clinical interpretation HDL-C is protective against vascular disease caused by lipid deposition. HDL-C levels > 1.0 mmol/L are associated with a decreased risk of coronary artery disease. HDL-C increases with exercise moderate alcohol consumption some lipid altering drug therapy. Levels are unreliable for up to 8 weeks with acute illness (e.g., myocardial infarction, major acute infection) and assessment should not be attempted during this time. Links References Australian NHF Lipid Management Guidelines. USA National Cholesterol Education Program Guidelines. Cardiovascular risk assessment profiles. RCPA Manual of Test Use, Version 4. RCPA, Sydney, 2004. Reference intervals sourced from Olympus assay literature. This page last reviewed and verified: 30 Oct, 2009 by C Chiang. CHBIS-01,11 (30/10/09) Page 1 of 1