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The motility of dendritic spines in the mouse visual cortex changes after one eye is closed. The dendrites of pyramidal neurons in the visual cortex have many spines, the density of which remains comparatively constant under normal conditions. Closure of one eye (contralateral in this example) during the critical period for binocular development enhances the motility of dendritic spines and over time results in an increase in the proportion of spines that receive synaptic input from the open eye. Similar changes in spine motility are not observed if the eye is closed after the critical period. (Reproduced, with permission, from Oray et al. 2004.) Source: Experience and the Refinement of Synaptic Connections, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: http://mhmedical.com/ Accessed: April 29, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
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