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Drug efficacy versus drug potency. The biologic responses elicited by two drugs that bind to the same site are presented in this representation as a
function of drug concentration. Efficacy refers to the maximal biologic response elicited by each drug. In this theoretical representation the partial agonist
elicits a smaller maximal response than the full agonist. However, efficacy is independent of the potency (Kd) of the drug; the partial agonist shown is in
fact more potent (possesses a higher affinity for the binding site) than the full agonist.
Source: Basic Principles of Neuropharmacology, Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 3e
Citation: Nestler EJ, Hyman SE, Holtzman DM, Malenka RC. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 3e; 2015
Available at: http://mhmedical.com/ Accessed: May 12, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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