Download Inferior olive

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The inferior olivary nucleus is the only source
of cerebellar climbing fibers
The Inferior Olive nucleus
Olivary neurons (Ramon Y Cajal)
HRP filled
olivary
neuronneuron
Intracellular
labeling
of olivary
Action potential in olivary neuron
Action potentials in olivary neuron
The effect of TTX on action potentials in olivary neuron
The effect of Mn2+ and Cd2+ on action potentials in olivary neuron
Two types of action potentials in olivary neuron
-55 mV
-60 mV
-60 mV
-60 mV
-68 mV
15 mV
1 nA
20 msec
15 mV
The Na+ and Ca2+ components of the two types of
action potentials
Independent activation of the action potentials
TTX
Refractory period of the action potentials
Refractory period of the action potentials
10 mV
The Inactivation curve of the low threshold action
potential
Possible mechanism of rhythmic activity
Ionic currents in Olivary neurons:
Na current – typical H&H current
Dendritic Ca current – high threshold
non-inactivating
Ca dependent, K current
Somatic Ca current – low threshold
inactivating
Possible mechanism of rhythmic activity
Electrical coupling between olivary neuron
Cell 2
Cell 1
20 mV Cell 1
Cell 2
Cell 1
Cell 2
5 mV
200 ms
20 mV
Cell 1
10 mV
2 mV
Cell 2
100 ms
200 ms
5
10 mV
Dye coupling between olivary neuron
The olivary glumerulus
Olivary Gap junction