Download CURRICULUM VITAE

CURRICULUM VITAE
NAME:
Keqiang Wu (吳克強)
EDUCATION
1980-1984 B.S., Biology, Sun Yat-Sen University, Guangzhou, China
1984-1987 M.S., Genetics, Institute of Genetics, Academy of Science, Beijing, China
1990-1994 Ph.D., Molecular Biology, University of Saskatchewan, Canada
PROFESSIONAL APPOINTMENTS
1994-1995 Postdoctoral Research Associate, DOE Plant Research Lab, Michigan
State University, USA
1996-1997 Postdoctoral Research Associate, Department of Medicine, McGill
University, Canada
1998-2001 Research Scientist, Eastern Cereal and Oilseed Research Center,
Agriculture and Agri- Food Canada, Canada.
2001-2006 Assistant Professor, Department of Biology, West Virginia University,
USA
2006-2012 Associate Professor, Institute of Plant Biology, National Taiwan
University, Taiwan
2012-present Professor, Institute of Plant Biology, National Taiwan University, Taiwan
PROFESSIONAL ACTIVITIES
 Editorial Board of PLoS ONE (2011-present)
 Guest editor of Frontiers in Plant Science (2013-2014)
 Member of American Society of Plant Biologist
AWARDS
• Graduate Scholarship, University of Saskatchewan, Canada (1990-1994)
• Postdoctoral Fellowship, Michigan State University, USA (1994-1995)
• Postdoctoral Fellowship, McGill University, Canada (1996-1997)
• Travel Award of American Society of Plant Biologist (2005)
• K. C. Wong visiting scholar, K. C. Wong Education Foundation and Chinese
Academy of Science (2006)
• Excellent publication award of National Taiwan University (2008-2014)
• Excellent research award of National Taiwan University (2010-2014)
• Excellent research award of Ministry of Science and Technology, Taiwan (2013)
PUBLICATIONS
Peer-reviewed Journals:
1) Singh P, Yekondi S, Chen PW, Tsai CH, Yu CW, Wu K, Zimmerli L*（2014）
Environmental history modulates Arabidopsis pattern-triggered immunity in
a HISTONE ACETYLTRANSFERASE1-dependent manner. Plant Cell 26:26762688.
2) Liu X, Yang S, Zhao M, Luo M, Yu CW, Chen C, Tai R, and Wu K* (2014)
Transcriptional repression by histone deacetylases in plants. Mol Plant 7, 764–772.
3) Luo M, Hung F, Yang S, Liu X, and Wu K* (2014) Histone lysine demethylases
and their functions in plants. Plant Mol Biol Rep 32:558–565.
4) Yuan L, Liu X, Luo M, Yang S, and Wu K* (2013) Involvement of Histone
Modifications in Plant Abiotic Stress Responses. J Integr Plant Biol 55: 892-901.
5) Liu X, Chen C, Wang K, Luo M, Tai R, Yuan L, Zhao M, Yang S, Tian G, Cui Y,
Hsieh H and Wu K* (2013) PHYTOCHROME INTERACTING FACTOR3
associates with the Histone Deacetylase HDA15 in repression of chlorophyll
biosynthesis and photosynthesis in etiolated Arabidopsis seedlings. Plant Cell 25:
1258–1273.
6) Zhou Y, Tan B, Luo M, Lin Y, Liu C, Chen C, Yu C-Wu, Yang S, Dong S,
Ruan J, Yuan L, Zhang Z, Zhao L, Li C, Chen H, Cui Y, Wu K* and Huang S*
(2013) HISTONE DEACETYLASE19 interacts with HSL1 and participates in the
repression of seed maturation genes in Arabidopsis seedlings. Plant Cell 25: 134–
148.
7) Luo M, Yu CW, Chen F, Zhao L, Tian G, X Liu, Cui Y, Yang JY, and Wu K*
(2012) Histone deacetylase HDA6 is functionally associated with AS1 in
repression of KNOX genes in Arabidopsis. PLoS Genet 8: e1003114. doi:
10.1371/journal.pgen.1003114.
8) Luo M, Wang YY, Liu X, Yang S, Lu Q, Cui Y, and Wu K* (2012) HD2C
interacts with HDA6 and is involved in ABA and salt stress response in
Arabidopsis. J. Exp. Bot. 63: 3297-3306.
9) Alinsug MV, Chen F, Luo M, Tai R, Jiang L and Wu K* (2012) Subcellular
localization of class II HDAs in Arabidopsis thaliana: nucleocytoplasmic
shuttling of HDA15 is driven by light. PLoS ONE 7(2): e30846.
10) Liu X, Yu CW, Dun J, Luo M, Wang K, Tian G, Cui Y, and Wu K* (2012)
HDA6 directly interacts with DNA methyltransferase MET1 and maintains
transposable elements silencing in Arabidopsis. Plant Physiol. 158: 119–129.
11) Liu X, Luo M, Zhang W, Zhao J, Zhang J, Wu K*, Tian L* and Duan J* (2012)
Histone acetyltransferases in rice (Oryza sativa L.): phylogenetic analysis,
subcellular localization and expression. BMC Plant Biology 12:145.
doi:10.1186/1471-2229-12-145
12) Gao Y, Yang S, Yuan L, Cui Y, and Wu K* (2012) Comparative analysis of
SWIRM domain-containing proteins in plants. Comp. Funct. Genomics
2012:310402.
13) Luo M, Wang Y, Liu X, Yang S, Wu K*, (2012) HD2 proteins interact with
RPD3-type histone deacetylases. Plant Signal Behav. 7: 608 – 610.
14) Liu X, Luo M, and Wu K*(2012) Epigenetic interplay of histone modifications
and DNA methylation mediated by HDA6. Plant Signal Behav. 7: 633 – 635
15) Luo M, Liu X, Singh P, Cui Y, Zimmerli L, and Wu K* (2012) Chromatin
modifications and remodeling in plant abiotic stress responses. BBA-Gene Regul
Mech. 1819:129-136.
16) Zhou Y, Chu P, Chen H, Li Y, Liu J, Ding Y, Tsang EW, Jiang L, Wu K, and
Huang S. (2012) Overexpression of Nelumbo nucifera metallothioneins 2a and 3
enhances seed germination vigor in Arabidopsis. Planta (2012) 235:523–537
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17) Yu CW, Liu X, Luo M, Chen C, Lin X, Tian G, Lu Q, Cui Y, and Wu K* (2011)
Histone Deacetylase6 interacts with Flower Locus D and regulates flowering in
Arabidopsis. Plant Physiol. 156: 173-184.
18) Chen L and Wu K* (2010) Role of histone deacetylases HDA6 and HDA19 in
ABA and abiotic stress response. Plant Signal Behav. 5: 1318-1320.
19) Chen L, Luo M, Wang Y and Wu K* (2010) Involvement of Arabidopsis histone
deacetylase HDA6 in ABA and salt stress response. J. Exp. Bot. 61: 3345-3353.
20) Song Y, Wu K, Dhaubhade S, An L and Tian L (2010) Arabidopsis DNA
methyltransferase AtDNMT2 associates with histone deacetylase AtHD2s activity.
Biochem. Biophys. Res. Commun. 396:187-192.
21) Fu G, Zhong Y, Li C, Li Y , Lin X, Liao B, Tsang E WT, Wu K*, Huang S (2010)
Epigenetic regulation of peanut allergen gene Ara h 3 in developing embryos.
Planta 231: 1049-1060.
22) Li C, Wu K, Fu G, Li Y, Zhong Y, Lin X, Zhou Y, and Huang S (2009)
Regulation of oleosin expression in developing peanut embryos through
nucleosome loss and histone modifications. J. Exp. Bot. 60: 4371-4382.
23) Alinsug MV, Yu C-W and Wu K* (2009) Phylogenetic analysis, subcellular
localization, and expression patterns of RPD3/HDA1 family histone deacetylases
in plants. BMC Plant Biol. 9: 37. doi: 10.1186/1471-2229-9-37.
24) Wu K*, Zhang L, Zhou C, Yu C, and Chaikam V (2008) HDA6 is required for
jasmonate response, senescence and flowering in Arabidopsis. J. Exp. Bot. 59:
225–234.
25) Liu Z, Zhou C and Wu K* (2008) Creation and analysis of a novel chimeric
promoter for the complete containment of pollen- and seed-mediated gene flow.
Plant Cell Rep. 27:995–1004
26) Ciou C, Wu K Yeh K (2008) Characterization and promoter activity of
chromoplast specific carotenoid associated gene (CHRC) from Oncidium gower
ramsey. Biotechnology Letters 30:1861-1866.
27) Fu W, Wu K* and Duan J (2007) Sequence and expression analysis of histone
deacetylases in rice. Biochem. Biophys. Res. Commun. 356：843-850.
28) Sridha S and Wu K* (2006) Identification of AtHD2C as a novel regulator of
abscisic acid responses in Arabidopsis. Plant J. 46: 124-133.
29) Zhou C, Zhang L, Duan J, Miki B and Wu K* (2005) HDA19 is involved in
jasmonic acid and ethylene signalling of pathogen-response in Arabidopsis. Plant
Cell 17: 1196–1204.
30) Yang Z., Tian L., Latoszek-Green M., Brown D. and Wu K.* (2005) Arabidopsis
ERF4 is a transcriptional repressor capable of modulating ethylene and abscisic
acid responses. Plant Mol. Biol. 58:585-596.
31) Yan Y., Lin X., Zhang Y., Wang L., Li Y., Wu K. and Huang S (2005) Isolation
of peanut cDNAs encoding arachins and conglutins by expressed sequence tags.
Plant Sci. 169: 439-445.
32) Tian L., Wu K., Hannam C., Latoszek-Green M., Sibbald S., Hu M., Brown D.,
and Miki B (2005) Analysis of eIF4A promoter elements for expression in plants.
J. Plant Physiol. 162: 1355-1366.
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33) Zhou C., Labbe H., Sridha S., Wang L., Tian L., Latoszek-Green M., Yang Z.,
Brown D.,Miki B., and Wu K.* (2004) Expression and function of HD2-type
histone deacetylases in Arabidopsis development. Plant J. 38: 715-724.
34) Zhou C., Miki B., and Wu K.* (2003) CHB2, a member of the SWI3 gene family,
is a global regulator in Arabidopsis. Plant Mol. Biol. 52: 1125-1134.
35) Wu K,* Tian L., Zhou C., Brown D., and Miki B. (2003) Repression of gene
expression by Arabidopsis HD2 histone deacetylases. Plant J. 34: 241-247.
36) Wu K., Hu M., Martin T., Wang C., Li X., and Miki B. (2003) The cryptic
enhancer elements of the tCUP promoter. Plant Mol. Biol. 51: 351-362.
37) Tian L., Wu K., Ouellet T., Foster E., Latoszek-Green M., Sibbald S., Miki B.,
Seguin and Brown D. (2003) Activity of elements from the tobacco cryptic
promoter, tcup, in conifer tissues. In Vitro Cell Devel Biol - Plant 39:193-202.
38) Wu K., Tian L., Hollingsworth J., Brown D. and Miki B. (2002) Functional
analysis of tomato Pti4 gene in Arabidopsis. Plant Physiol. 128: 30-37.
39) Miki B., Brown D., Tian L., Malik K., and Wu K. (2002) The role of histone
deacetylases in flowering. Flowering Newsletter 33: 3-6.
40) Tian L., Wang, H., Wu K., Latoszek-Green M., Hu M., Miki B., and Brown D.
(2002) Efficient recovery of transgenic plants through organogenesis and
embryogenesis using a cryptic promoterto drive marker gene expression. Plant
Cell Rep. 20:1181-1187.
41) Malik K., Wu, K., Li, X., Martin-Heller, T., Hu, M., Foster, L., Tian L., Jordan,
M., Brown, D., Gleddie, S., Simmonds, D., Zheng, S., Simmonds, J., and Miki, B.
(2002) A constitutive gene expression system derived from the tCUP cryptic gene
regulatory elements. Theor. Appl. Genet. 105: 505-514.
42) Akache B., Wu K. and Turcotte B. (2001) Phenotypic analysis of genes encoding
yeast zinc cluster proteins. Nucleic Acids Res. 29: 2181-2190.
43) Wu K., Malik K., Tian L., Hu M., Martin T., Foster L., Brown D. and Miki B.
(2001) Enhancers and core promoter elements are essential for the activity of a
cryptic gene activation sequence from tobacco, tCUP. Mol. Genet. Genomics 265:
763-770.
44) Wu K., Tian L., Malik K., Brown D. and Miki B. (2000) Functional analysis of
HD2 histone deacetylase homologs in Arabidopsis thaliana. Plant J. 20: 19-28.
45) Wu K., Malik K., Tian L., Brown D. and Miki B. (2000) Functional analysis of a
RPD3 histone deacetylase homolog in Arabidopsis thaliana. Plant Mol. Biol. 44:
167-176.
46) Wu K., Li L., Gage D. and Zeevaart J. (1996) Molecular cloning and
photoperiod-regulated expression of gibberellin 20-oxidase from long-day plants
spinach. Plant Physiol. 110: 547-554.
47) Xu Y., Li L., Wu K., Peeters A., Gage D. and Zeevaart J. (1995) GA5 locus of
Arabidopsis encodes a multifunctional gibberellin 20-oxidase: molecular cloning
and functional expression. Proc. Natl. Acad. Sci. USA 92: 6640-6644
48) Wu K., Cossins E. and King J. (1994) Folate metabolism in Datura innoxia. In
vivo and in vitro folylpolyglutamate synthesis in wild-type and methotrexateresistant cells. Plant Physiol. 104: 373-380.
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49) Wu K., Mourad G. and King J. (1994) A valine-resistant mutant of Arabidopsis
displays an acetolactate synthase with changed feedback control. Planta 192: 249255.
50) Wu K. and King J. (1994) Biochemical and genetic characterization of 5-Fluoro2'-deoxyuridine resistant mutants of Arabidopsis. Planta 197: 117-122.
51) Wu K., Atkinson I., Cossins E. and King J. (1993) Methotrexate resistance in
Datura innoxia. Uptake and metabolism of methotrexate in wild type and resistant
cells. Plant Physiol. 101: 477-483.
*Corresponding author
Book Chapters:
1) Miki B. and Wu K. (2003) Control of gene expression by histone deacetylases. In
“Plant Biotechnology 2002 and Beyond”, I. K. Vasil, ed., Kluwer Academic
Publishers, Dordrecht, Netherlands, pp. 211-214.
2) Zhang C-Q., Liu Y., Eschen W.M., and Wu K. (2003) Identifying regulatory
signals in DNA-sequences with a non-statistical approximation approach. In
“Proceeding of the 2003 IEEE Bioinformatics Conference”. pp., 593-597.
PATENT
 B Miki, T Ouellet, J Hattori, E Foster, H Labbé, T Martin-Heller, L Tian, D
Brown, P Zhang, K Wu. Cryptic regulatory elements obtained from plants. US
Patent # 7,303,873. (issued Dec 4, 2007).
 Simmonds, J., Cass, L., Harris L., Allard S., Malik, K., Martin-Heller, T., Brown,
D., Hu, M., Miki, B., Wu, K. Regulatory region of a lipid transfer protein
(LtpW1) from aleuron tissue of wheat. US Patent # 6,939,958 (issued Sept. 6,
2005).
 Wu, K., Miki, B., Tian, L., Brown, D. Repressing gene expression in plants. US
Patent # 6,808,926 (issued October 26, 2004).
 Ouellet, T., Miki, B.M., Martin-Heller, T., Tian, L., Brown, D.C., Zhang, P.,
Hattori, J., Malik, K., Wu, K., Theilmann, D.A., Tropiano, R. Translation
regulatory elements. US Patent # 6,784,289 (issued Aug. 31, 2004).
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