Download The Structure and Function of Macromolecules

Nucleic Acids
Structure
 Cellular Function

Nucleic Acids
Structure
 Cellular Function

Nucleic Acids
Structure
 Cellular Function

Nucleic Acids
Structure
 Cellular Function
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Central Dogma!
Central Dogma!
Central Dogma!
Proteins
Structure
 Cellular Function

Proteins
Structure
 Cellular Function

Proteins
Structure
 Cellular Function

Proteins
Structure
 Cellular Function

Proteins
Structure (amino acid)
 Cellular Function
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Proteins
Structure (polypeptides)
 Cellular Function
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Protein – in depth

Four structural levels
◦
◦
◦
◦
Primary
Secondary
Tertiary
Quaternary
Proteins – in depth
Proteins – in depth
Proteins – in depth
Proteins – in depth
Proteins – in depth

“Layers”
Protein – in depth

Denaturing
(change in shape/conformation)
◦ Heat
◦ pH
Try This! (True or Flase?)
1. Primary protein structure is stabilized by peptide
bonds between a linear sequence of amino acids.
2. Secondary protein structure is stabilized by
hydrogen bonds between R groups on adjacent
amino acids.
3. Both primary and tertiary protein structure may
be stabilized by covalent bonds.
4. All proteins display primary, secondary, and
tertiary levels of protein structure.
Try This! (True or Flase?)
1.Primary protein structure is stabilized by
peptide bonds between a linear sequence of
amino acids.
2. Secondary protein structure is stabilized by hydrogen
bonds between R groups on adjacent amino acids.
3.Both primary and tertiary protein structure
may be stabilized by covalent bonds.
4.All proteins display primary, secondary, and
tertiary levels of protein structure.
Try This! (Matching)
Levels of protein structure Interactions
1. Primary
groups
a. Interactions between R
2. Secondary structure
b. Hydrogen bonds between
constituents of the
polypeptide backbone
c. Aggregations between
polypeptides
3. Tertiary structure
4. Quaternary structure
d. Peptide bonds
Try This! (Matching)
Levels of protein structure Interactions
1. Primary
a. Interactions between R
groups
2. Secondary structure
b. Hydrogen bonds between
constituents of the
polypeptide backbone
c. Aggregations between
polypeptides
3. Tertiary structure
4. Quaternary structure
d. Peptide bonds
Practice!
#1-20 p. 36-38
 Animations online!
 Self Quiz Questions from Campbell
(more difficult)


CHECKPOINT next class 
◦ Concept 1