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Syllabus: Human Metabolic Biochemistry Unless otherwise stated, lecture is at 11 AM in Main Auditorium Date Topic Lecturer Reading Block I. Enzymes and Intermediary Metabolism (Part 1) – 11 Lectures, 29% M, Dec. 1 T, Dec. 2 W, Dec. 3 Th, Dec. 4 F, Dec. 5 Enzymes: Properties and Catalytic Mechanisms Enzymes: Kinetics and Enzyme Inhibition Enzymes: Regulation and Drug Design Metabolic Design Glycolysis I Blake Blake Blake Franklin Franklin Ch. 6 Ch. 6 Ch. 6, Box 26-2 Ch. 13 Ch. 14 M, Dec. 8 T, Dec. 9 W, Dec. 10 Th, Dec. 11 F, Dec. 12 Glycolysis II Gluconeogenesis Pentose Phosphate and Shunts Metabolism of sugars other than glucose Glycogen metabolism Franklin Blake Blake Blake Franklin Ch. 14 Ch. 15 Ch. 15 Ch. 15 Ch. 15 S, Dec. 13 Email of Last EC Quiz Questions Due by Noon Su, Dec. 14 Block 1 On-line Practice Quiz Available at Noon (until Noon on Monday, Dec 15th) M, Dec. 15 M, Dec. 15 M, Dec. 15 T, Dec. 16 W, Dec. 17 Regulation of Glucose Metabolism (1 PM – 1:50 PM) Block 1 Review Session (2 – 2:50 PM) Blake Franklin and Blake Block 1 Practice Exam Clicker Session (3 –3:50 PM) Franklin Block 1 Study Day Biochemistry Block 1 Exam (9 AM - Noon) Ch. 15 Block II. Intermediary Metabolism (Part 2) – 11 Lectures, 29% T, Jan. 6 W, Jan. 7 Th, Jan. 8 Th, Jan. 8 F, Jan. 9 Pyruvate dehydrogenase and CAC I Citric Acid Cycle II Oxidative phosphorylation (9:45 AM – 10:45 AM) Lipid metabolism I Lipid metabolism II Blake Blake Blake Franklin Franklin M, Jan. 12 M, Jan. 12 Steroid biosynthesis (9:45 AM – 10:45 AM) Clinical Correlation: Dysmorphogenesis - Defects in Cholesterol Biosynthesis Nitrogen Metabolism I: The Urea Cycle Nitrogen Metabolism II: Amino Acids Nitrogen Metablism III Nucleotide Metabolism (9:45 AM – 10:45 AM) Block 2 Review Session Blake Ch. 21 Andersson Ch. 21 T, Jan. 13 W, Jan. 14 Th, Jan. 15 F, Jan. 16 F, Jan. 16 Franklin Franklin Franklin Franklin Franklin and Blake Ch. 16 Ch. 16 Ch. 19 Ch. 17 Ch. 17 Ch. 18 Ch. 18 Ch. 22 Ch. 22 F, Jan. 16 S, Jan. 17 Email of Last EC Quiz Questions Due at Noon On-line Practice Quiz Available at Noon (until Noon on Sunday Jan 18th) M, Jan. 19 T, Jan. 20 No Class - Martin Luther King Day Biochemistry Block 2 Exam (9 AM - Noon) Block III. Diabetes: A Metabolic Disease – 8 Lectures, 22% W, Feb. 4 Th, Feb. 5 F, Feb. 6 Nutrition I - Micronutrients Nutrition II - Macronutrients Nutrition III – Disease States Franklin Franklin Franklin M, Feb. 9 T, Feb 10 W, Feb 11 Th, Feb. 12 F, Feb. 13 F, Feb. 13 S, Feb. 14 Clinical Correlation: Diabetes (9:45 AM – 10:45 AM) Diabetes I – Central Glucose Metabolism Diabetes II - Glycation Diabetes III – Effects of Diabetes Diabetes IV – Genetic, Environment and Obesity Email of Last EC Quiz Questions Due at Noon On-line Practice Quiz Available at Noon (until Noon on Sunday Feb 15th) Fonseca Franklin Li Franklin Franklin M, Feb. 16 T, Feb. 17 Biochemistry Block 3 Exam (9 AM - Noon) NBME Comprehensive Biochemistry Review #1 Feb. 23-27 Mardi Gras and Spring Break – No Class F, Mar. 13 NBME Comprehensive Biochemistry Review #2 (9:45 AM – Noon) Ch. 23 Ch. 23 Ch. 23 Ch. 23 M, Mar. 16 NBME Biochemistry Exam (8:15 AM – Noon), 20%*** *** If student performs better (% score) on NBME exam than in average % of three block exams, grade will be based on 50% for three block exams (proportionately scaled) and 50% on NBME score.