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Influence of Atrioventricular Interaction on Mitral Valve Closure and Left Ventricular Isovolumic Contraction Measured by Tissue Doppler ImagingClinical Perspective by Annelies Decloedt, Tinne Verheyen, Stanislas Sys, Dominique De Clercq, Bart Bijnens, and Gunther van Loon Circ Cardiovasc Imaging Volume 6(1):109-116 January 15, 2013 Copyright © American Heart Association, Inc. All rights reserved. Example of a radial tissue Doppler imaging (TDI) velocity curve in the left ventricular free wall and an anatomic M-mode through the mitral valve, derived from the same right parasternal modified 4-chamber view. Annelies Decloedt et al. Circ Cardiovasc Imaging. 2013;6:109-116 Copyright © American Heart Association, Inc. All rights reserved. Graphical illustration of radial tissue Doppler imaging velocity measurements of pre-ejection left ventricular wall motion. Annelies Decloedt et al. Circ Cardiovasc Imaging. 2013;6:109-116 Copyright © American Heart Association, Inc. All rights reserved. Timing of mitral valve closure (MVC), second mitral valve closure after minor valve reopening (MVC2), end of isovolumic contraction (end IVC), and recoil of the left ventricle during atrial relaxation (rA) relative to the onset of QRS measured on the ECG. AV indicates atrioventricular; RVP, right ventricular pacing without preceding atrial contraction; and SR, sinus rhythm. Annelies Decloedt et al. Circ Cardiovasc Imaging. 2013;6:109-116 Copyright © American Heart Association, Inc. All rights reserved. Isovolumic contraction time (IVCT) calculated as time of aortic valve opening (AVO), time of mitral valve closure (MVC), as measured by M-mode. Annelies Decloedt et al. Circ Cardiovasc Imaging. 2013;6:109-116 Copyright © American Heart Association, Inc. All rights reserved.