Download Advanced Immunology Course Code: Credit Units: 5

Annexure ‘CD – 01(XXII)’
FORMAT FOR COURSE CURRICULUM
Course Title: Advanced Immunology
Credit Units: 5
L
T
P/S
SW/F
W
3
-
2
-
Course Code:
Course Objectives: To be familiar with advances in study of immune system,
hematopoietic stem cells, lymphocytes, mucosal immunity and immunology
diseases.
Prerequisites: Basic Immunology and knowledge of cell Biology
Student Learning Outcomes: At the end of this course, the students will be able to:
•
•
•
•
•
Define and analyze the features of tolerance and autoimmunity.
Describe the various aspects of mucosal immunity.
Illustrate with examples the process of immunodeficiency and various
conditions of immunodefieciency
Describe the mechanism of hypersenstitivity
Interpret immune response in various diseases
Course Contents/Syllabus:
Weightage (%)
Module I
Descriptors/Topics
Autoimmunity
Tolerance & its mechanisms, Systemic & organ specific diseases,
Autoimmunity mechanisms, Nature of autoantigens, General characteristics
of autoantibodies, Altered antigens, Genetics of autoimmunity, cytokines in
systemic autoimmune disease, environmental influences on systemic
autoimmunity, apoptosis abnormalities in systemic autoimmune
disease.Systemic lupus erythematosus, Rheumatoid arthritis, Animal models
of autoimmunity, therapy of autoimmune diseases
Module II
Descriptors/Topics
Mucosal immunity
Organization of the Mucosal immune system, Peyer’s patches, Inductive and
effector sites of the mucosal immune system, Intraepithelial lymphocytes,
Mucosal cell trafficking and homing Mucosal barrier: Epithelial Cells,
Mucosal microbiota, Mucosal antibodies and immune responses
Mechanisms for Mucosal & Oral Tolerance, Coeliac Diseases, Mucosal
immunopathology: Immunoglobulin A Deficiency, Inflammatory Bowel
Disease, Ulcerative colitis , Crohn’s Disease Mucosal Allergies
Module III
20
20
15
TOTAL
CREDIT
UNITS
4
Descriptors/Topics
Immunodeficiency
Primary immunodeficiency (Eg.SCID)
Secondary/Acquired immunodeficiency (Eg. AIDS), Immunosuppression by
HIV
Module IV
Descriptors/Topics
Hypersensitivity
Causes and types of hypersensitive diseases, role of immune cells,
enzymes, IgE in allergic reactions. Celiac disease, Immunology of
Bacterial diseases, recent development of drugs and vaccines for
Tuberculosis, Leprosy and pneumonia, Immunology of viral diseases,
Sign, symptoms and Pathogenesis of swine flu, Structure, replication
and route of HIV, Infleunza, H1N1, Recent Vaccines and drugs for
retroviruses. Immunology of Parasitic diseases, Recent Vaccines and
drugs for Malaria, Leishmaniasis, Filariasis
30
Module V
Antibody assays, passive haemagglutination, Coomb’s test, flow
cytometry, FACS, Variants of ELISA, Various cellular assays such as
TLC, DLC, HLA typing, ELISPOT, Lymphocyte transformation
assay, Mixed lymphocyte reaction (MLR) and separation of
monocytes and lymphocytes
15
Pedagogy for Course Delivery: interactive classroom teaching from text books,
published reviews and articles
Lab/ Practicals details, if applicable:
List of Experiments:
 Demonstration of Immunophenotyping by FACS
 Demonstration of Cytokine quantification by ELISPOT
 Lymphocyte migration assay

Assessment/ Examination Scheme:
Theory L/T (%)
Lab/Practical/Studio (%)
80
20
Total
100
Theory Assessment (L&T):
Continuous Assessment/Internal Assessment
Components
Weightage (%)
Class
Test
Attendance
Assignment
15
5
10
Lab/ Practical/ Studio Assessment:
Continuous Assessment/Internal
Assessment
Components
Class test
Practical
Viva
(Drop down
(practical
record
based)
Weightage
15
5
10
(%)
End Term
Examination
70
End Term Examination
Practical
Practical
performance record
40
10
Viva
20
Text : Fundamental immunology , W Paul, 7th edition. Lipincott Williams & Wilkins.
(2012)
References: Janeway’s Immunobiology, K. Murphy, 8th edition, Garland Science,
2012.
Cellular and Molecular Immunology, AK Abbas, AH Lichtman, S. Pillai,
th
6 edition, Elsevier (2012)