Download Cancer Poster - Cell Signaling Technology

The Pathways in Human Cancer poster summarizes some of the key
signaling pathways implicated in tumorigenesis and tumor
progression in humans. Within each pathway, gene products known
to be mutated in human tumors—oncogenes and tumor suppressor
genes—are coded with information on types of genetic alterations
and conferred capabilities to the tumor. Proteins are shown using
structural representatives. New to this revised poster edition are
signaling pathways for Hippo Signaling, Autophagy, Warburg Effect,
and Epigenetic Regulation.
C
Revised Edition
Ras Common protein name
Structural representative
from PDB
Ras
mut
oncogene
tumor suppressor
Type of genetic alteration
mut
Type of conferred capability
Direct stimulatory modification
This poster was created by scientists at Cell Signaling Technology in
collaboration with Robert A. Weinberg and others at the forefront of
cancer research. Expanded versions of each pathway, including
additional downstream signaling nodes, can be found at
www.cellsignal.com/CSTcancer.
Direct inhibitory modification
Multistep stimulatory modification
Tentative stimulatory modification
Transcriptional contribution
TYPES OF GENETIC ALTERATIONS:
Autophagy
autophagosome
ed
ulat s
Reg cytosi
Exo
Integrin
trans, mut
LC3-II
Src
FAK
g
ILK
Atg16/12/5
al
in
GRB2
Rab8a (c-Mel)
mut
LC3-I
as
Receptor Tyrosine Kinase (RTK)
mut, trans, amp, exp
ULK1
FIP200
Atg13
mut
PI3K
Gab1
Cbl
Rictor
Akt
mut, del
PTEN
PI3K
amp, mut, exp
PP2A
mut
[PIP3 ]
PDK1
mut,del
mut
Actin
Cytoskeleton
Ras
γ
α
Hypoxia
β
VHL
mut
Signa
ling
AC
LDHA
MP1
p90RSK
GPCR
γ
α
HIF-1α(-2α)
p90
SynGAP
mut
MEK1/2
β PLCβ
RasGAP
PLCβ
α
Ras
MP1
PI3K
ZNRF3/RNF43
HIF-1α(-2α)
HIF-1β
Frizzled
ERK1/2
mut
in
l
yc
p15
amp, exp
amp, trans
CBP
β-catenin
β-catenin
TCF/LEF
Ubiquitin
mut
mut
Rad52
TEAD
YAP/TAZ
Smad
14-3-3
YAP
p107
mut
BMPRII
Smad1/5/8
mut
Smad1/5/8
Smad4 mut
Smad1/5/8
SARA
Smad2/3
TGFβ RII
mut
ERK
cy
mut
Smad7
mut
MDM2
TAK
TAB2
MKK3/6
p53
NICD
NIC
p300
CDK7
Cyclin H
,
yc
cy
in
cl
lin
D,
E
HAT
c
cy
Gli
amp, trans
NICD
NUMB
PKA
m
mut
Gli
yc
trans
CDO
BOC
Su(Fu)
amp, trans
,m
Cleaved
Notch
HES1
nD
Myc
Miz-1
Delta
Jagged
CSL/CBF1
CDK2
Cyclin A
KIF-7
mut
Ptch
mut
Smo
amp, trans
Gli
Epigenetic Signaling
Myc
Max
Fos
Jun
Transcription
KMT2/MLL
KDM6A/UTX
KMT4/DOT1L
BRD4
TET
SirT1
SWI/SNF
p38
CDO
BOC
mut
Hh
Su(Fu)
KIF-7
mut
KMT6/EZH2
DNMT3
mut
mut
JNK
0
0101 10 1
0 11
0100110110101
0
01
1 011
10
1101100101
01
0110 01
Ptch
Smo
This poster accompanies the textbook The Biology of Cancer, Second Edition
by Robert A. Weinberg and published by Garland Science.
Dr. Weinberg is a founding member of the Whitehead Institute for Biomedical
Research and the Daniel K. Ludwig Professor of Cancer Research at the
Massachusetts Institute of Technology.
0
1101100101
1 011
0
www.cellsignal.com/CSTcancer
Cell Signaling Technology would like to thank
digizyme for their collaboration on the design
and concept of this poster. Please visit
www.digizyme.com to see more of their work.
011011011011 010011
0
01
Scienstists at Cell Signaling Technology collaborate
with key opinion leaders in cancer research to create
reference pathway diagrams that reflect the latest
thinking in the research community. Over 40 pathway
diagrams currently exist, including the pathways
represented here and many others.
1011
MKK7
Presenilin
amp
Cdc2
Cyclin A
exp
TAB1
TACE
p27
mut
ARF
mut
mut
Fringe
amp
MDM2
trans
Furin
Sin3
CSL/CBF1
p21
HPV-E6
Smad2/3
Smad4
Smad2/3
IKKβ
Dsh
vir
p21
cli
IKKα
IκB
TNFR
TRAF
3
HDAC
Aurora
A
E2F
Smurf
Smad4
Chk2
TRAF
2/6
NIK
NFκB2
RelB
amp, exp
HIPK2
1011
Signaling
Ras
TGFβ
Miz-1
Smad2/3
Smad4
mut, amp
mut
Chk1
Cdc25
B/C
mut, amp
mut
DNAPK
p53
mut
E2F
Smad2/3
mut
TAB2
Smad7
BMPRI
NLK
BRCA1
mut
NEMO
mut
mut,del
NBS1
IKKβ
Hedgehog Signaling
TAK TAB1
ATM
ATR
Cdc25A
7
SAV1
Smad4
mut
TNFR
Notch
mut,del
p2
LATS1/2
MOB1
mut
*
1,
Mst1/2
trans
NFκB1/2
RelA
IR
mut, del
p2
mut
mut
5,
Smad1/5/8
*
FANC
D2
Wee1A
YAP/TAZ
Mer
KIBRA
CD44
FAT4
Cdc2
Cyclin B
amp,exp
CDK2
Cyclin E
TRADD
RAIDD
TRAF2
IκB
(Active)
DNA Damage
IKKα
NFκB1/2
RelA
cyclin E, A
myc, cdc2
p107, E2F
DP E2F
p1
Hippo Signaling
14-3-3
α 12/13
RIP
MEKK3
CAD
mut
Abl
Rad51
α -catenin
FRMD
ICAD
mut
UV
DNA Repair
CDK7
Cyclin H
αs
PARP
R
Rb
(Inactive)
mut
γ β
TAB3
Lamins
Notch Signaling
β-catenin
TAK TAB2
Casp-3,6,7
DP E2F
myc,
LGR4,5,6
β-catenin
Rb
44
mut
mut
Src
Myd88
cyclin D
PAR-1
FLIPs
IL1R
TRAF6
mut,del
mut
HDAC
D, CD
LRP5/6
p53
IRAK
cIAP
vir
HPV-E7
mut
D
p19
mut
TRADD
FADD
Casp-8,10
Bid
Casp-9
AIF
Fas/DR
ASK
CytC
Apaf-1
Smac
CAD
PP2A
APC
WTX
Axin
Dsh
GPCR
CDK4/6
Cyclin D
trans
Cdc25A
cyclin
GSK-3β
CKI
Bak
m
RAR
E-cadherin
p18
amp
Wnt5A
p120
lin
SOX
PAR-1
mut
cyc
mut
p16
D
yc
other TFs
amp, mut, exp
Wnt1
MKK7
STAT STAT
FKHR/
FOXO
mut
,c
Akt
Dsh
nD
cycli
exp
Akt
Elk-1
, myc
Fos
Jun
Ubiquitin
CKI
Myc
Max
CREB
amp, mut, exp
[PIP3 ]
tBid
PUMA
01101
Wnt Signaling
PI3Kγ
mut
JNK
trans
trans
mut, amp
ERK1/2
amp, mut, exp
mut
NOXA
RasGEF
R-spondin
Bcl-2
Casp-2
mut
PKC
γ
mut
Bcl-2
p90RSK
Ras c-Raf
Bax
Death Receptor / NF-κB Signaling
RasGRP
Akt
Bax
JNK
ERK1/2
[DAG]
Frizzled
Bcl-xL
RSK
mut
[IP3 ]
citrate
mut
RasGRF
GPCR
Bad
XIAP
amp
CAMKII
[Ca ]
exp
p27
MDM2
mut
Krebs
Cycle
14-3-3 Bim
Cyclin D p21
HIF-1β
β
2+
TGFβ
IDH2
PKA
[cAMP]
GPCR
TGFβ RI
lactate
ERK1/2
ligand
BMPs
citrate
IDH1
pyruvate
MEK1/2
Fatty acid
synthesis
F-6-P
Fructose
Bisphosphate
JNK
GPCR
mut
R-spondin
PFK
PKM2
mut
HPH
EPAC
mut
G-6-P
c-Raf
PAK1
ect
Hexokinase
14-3-3
Normoxia
Glucose
transporter
Eff
S6K
GSK-3
urg
Rac
RTK
rb
Wa
Cdc42
KSR
mut
Sustained angiogenesis
IRS-1
p53
B-Raf
Limitless replicative potential
[PIP3 ]
Rho
Rap
∞
g
LKB1
Raptor
14-3-3 c-Raf
na
lin
mut
mTOR
Crk
Raf-1
Tissue invasion & metastasis
ig
mTOR
NF1
C3G
Increased expression
(unknown mechanism)
Insensitivity to anti-growth signals
tS
Rheb
RhoGEFs
mut, del
exp
Gab2
RalBP1
GRB2
VEGF
EPO
PDGF
TSC2
TSC1
mut
4E-BP
SOS
Viral infection
PDK1
PI3K
class III
Beclin
Atg14
RasGAP
ALK
ROS1
EGFR
HER2
vir
(amino acids
& glucose)
RalA
RalB
Deletion
Ak
AMPK
Nutrients
RalGEF
Ras
del
mut
Rap
mut
Translocation
PI3K
R
Angiogenesis
trans
Self-sufficiency in growth signals
Shc Rasmut
RIAM/Talin
Si
gn
phagopore
membrane
nucleation
GRAF
SOS
Amplification
JAK
Atg4
exp
mut
amp
TYPES OF CONFERRED CAPABILITIES:
JAK
SHP2
STAT
GRB2 SOS
STAT
Atg7/3
PI3K
Point mutation
Evading apoptosis
SQSTM1
t
cys
Exomplex
Co
del
Cytokine
Receptor
SHP1
mut
Hardcover
Paperback
ISBN 978-0-8153-4219-9
ISBN 978-0-8153-4220-5
www.garlandscience.com