Download Slide 1

Neuronal growth cones. A. Drawings of growth cones by Santiago Ramón y Cajal, who discovered these cellular structures and inferred their function.
B. The diverse morphologies of growth cones are visualized in dye-labeled retinal ganglion neurons in the mouse. Note the similarities with Cajal's
drawings. (Reproduced, with permission, from Carol Mason and Pierre Godemont.)
C. The three main domains of the growth cone—filopodia, lamellipodia, and a central core—shown by whole-mount electron microscopy. (Reproduced,
with permission, from Bridgman and Dailey 1989.)
Source:
and Guidance
Axons,
Principles
of Neural
Fifth Editon
D. The growth
cone The
of a Growth
neuron from
Aplysia inofwhich
actin
and tubulin
have Science,
been visualized.
Actin (purple) is concentrated in lamellipodia and filopodia,
whereas tubulin
and microtubules
(aquamarine)
are concentrated
in theSA,
central
core. (Image
reproduced,
withofpermission,
from Fifth
Paul Editon;
Forscher
andAvailable
Dylan
Citation:
Kandel ER, Schwartz
JH, Jessell
TM, Siegelbaum
Hudspeth
AJ, Mack
S. Principles
Neural Science,
2012
Burnette.)
at: http://mhmedical.com/ Accessed: May 12, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved