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1,900 employees ‘‘ PLIVA, the largest pharmaceutical company in Croatia ➋➊ The biggest foreign investor in Croatia The broadest portfolio of generic medicines One of the largest companies overall in Croatia* An investment cycle of USD 200 million 2012 – 2014 Headquarters Croatia: More than 90 years in existence Second largest exporter in 2012 Inventor of global antibiotic blockbuster azithromycin 30 million injections and 10 million creams and ointments yearly Employer of choice in Croatia** ➊ PLIVA Croatia Ltd. Prilaz baruna Filipovića 25 10000 Zagreb Tel: + 385 1 37 20 000 ➋ Manufacturing site in Zagreb PLIVA Croatia Ltd. Prilaz baruna Filipovića 25 10000 Zagreb R&D site in Zagreb PLIVA Croatia Ltd. Prilaz baruna Filipovića 29 10000 Zagreb 5.5 billion tablets yearly Manufacturing site in Savski Marof PLIVA Croatia Ltd. Prudnička cesta 54 10291 Prigorje Brdovečko www.pliva.com Teva Europe Piet Heinkade 107 1019 GM Amsterdam The Netherlands Tel: +31 (0)20 2193 200 www.tevaeurope.com *Lider (Business Weekly) edition May 2013 ** National Research Report 2013 HQ/CPE/13/0006 ’’ Teva, your partner in healthcare ‘‘ Teva is one of Croatia’s major exporters, with over 80% of products intended for export ’’ Teva in Croatia PLIVA, a member of the Teva Group is the largest pharmaceutical company in Croatia with over 90 years of successful pharmaceutical experience. Our success and status is largely attributed to our in-house research and development of finished dosage forms and active pharmaceutical ingredients, our highly competent employees, innovative technologies and continuous investments in production. As a result, the site in Zagreb is currently one of the Teva Group’s leading R&D centers. We are also one of Croatia’s major exporters, with over 80% of products intended for export. Who we are Teva is a global generic pharmaceuticals leader and one of the top fifteen pharmaceutical companies in the world. We specialize in the development, manufacturing and marketing of a wide range of generic and branded products, as well as Active Pharmaceutical Ingredients (APIs). Teva is a global leader in generic medicines and has a track record of innovation in new medications in bio-similars, women’s health, autoimmune diseases, respiratory, central nervous system and transplantation. At the heart of everything we do, is our vision to be the most indispensable medicines company for the world, executing on our obligation to our patients, customers, shareholders and employees. There are 2 sites in Croatia: the headquarters, R&D center and a production site are located in Zagreb, while production of API is located at the site in Savski Marof. Every year, we manufacture 5.5 billion tablets, 30 million injections and 10 million creams and ointments. Teva’s economic footprint Our activities in Croatia In Croatia, our operations comprise of the production of finished dosage forms and active pharmaceutical ingredients, commercial operations (marketing and sales activities in Croatia and Southeast Europe) and research and development of generics and active pharmaceutical ingredients. Production of finished products Our Zagreb site specialises in the production of oral solid forms, sterile forms, creams and ointments. It mainly manufactures tablets, which are delivered to some 40 different markets, primarily the USA, Russia, Ukraine and Croatia. Projects for increasing the current capacities of the oral solid forms facility are underway, with the intention of further increasing production volume. Thanks to the approvals by the US Food and Drug Administration (FDA), the British Medicines and Healthcare Products Regulatory Agency (MHRA), the Croatian Agency for Medicinal Products and Medical Devices (HALMED) and other relevant European agencies, we are compliant with the highest global quality standards required for international markets. Our Zagreb production site plays a vital role for various Teva markets, and is one of the key strategic production sites for the entire TEVA Group. Development & production of Active Pharmaceutical Ingredients The development of new APIs and the production of previously registered APIs are carried out at two sites: Zagreb and Savski Marof. Production complies with strictly defined international standards, and is regularly audited by a number of foreign regulatory agencies and business partners. Currently, Teva is investing USD 100 million in TAPI (Teva Active Pharmaceutical Ingredients) Croatia’s new facility which will increase current capacities and ensure the highest environmental protection standards. Research and Development Our current status and achievements to date may be largely attributed to in-house research and development activities which have a 70-year long tradition. Clearly defined research and project management processes, a focus on niche areas, the use of state-of-the art technologies and scientific methods and systematic protection of intellectual property rights are the basic components of our research and development strategy that we conduct in Croatia. Currently, this strategy is strongly focused on the development of generic medicines, with Zagreb acting as one of the most important research centers within the Teva Group. 2012 – 2014 – USD 200 million investment cycle The ongoing investment cycle is one of the biggest in the company’s history amounting to about USD 200 million. The projects in Savski Marof include the construction of wastewater and process gas treatment facilities and the expansion of multipurpose synthesis facilities. The investments into environmental protection rely on Best Available Techniques in line with the IPPC Directive and best practice in the European Union. At the same time, the new facility for the production of finished dosage forms in Zagreb will soon start to operate. This will additionally increase the current capacities, already now mostly dedicated to exports to international markets, with the USA and Russia as the major markets. Our major export markets are the USA and Russia. We are one of Croatia’s major exporters, with over 80% of products intended for export. Getting our medicines to the patients who need them Teva’s production portfolio includes a large number of finished dosage forms covering almost all therapeutic groups, a broad OTC portfolio and active pharmaceutical ingredients. Our strong Rx product portfolio covers all major therapeutic groups: cardiovascular, gastrointestinal, anti-infectives, oncology, musculoskeletal, neurological, respiratory, psychiatric diseases as well as products for diabetes and pain. Registration of several new products is currently planned. ‘‘ We support projects of non-profit, non-governmental and charitable associations, and associations for persons with special needs ’’ Patients at the heart of everything we do At Teva, we’re passionate about improving quality of life and healthcare globally. This is our ongoing mission as we touch the lives of millions of patients every day, and billions of patients every year. Through many years of successful cooperation we have built solid, patient-oriented relationships with the entire professional community, including primary healthcare doctors, specialists, pharmacists and wholesalers. www.plivazdravlje.hr is a specialized healthcare portal intended for patients and anyone wishing to find out more about various healthcare and medical topics in a clear and accessible way. The portal offers detailed information about diseases, symptoms, diet, exercises and other everyday topics. Among other things, the interactive portal contains the following sections: Virtual Atlas, Disease Manual, Medical Lexicon, Nutrition by Disease, Allergy Traffic Light for several Croatian towns, Ovulation Calendar and Asthma Centre. To make the portal even more accessible to patients and the community, we have introduced free smartphone applications. PLIVA also publishes specialized brochures for patients and their families, dedicated to specific areas and covering diseases and conditions such as Diabetes, Allergies, Cardiovascular and much more. Teva: a responsible healthcare partner Teva is committed to improving global healthcare. We recognize our responsibility to support the communities we serve. We focus our involvement in the community in the countries in which we operate, through a range of activities to enhance access to medicines and contribute to the well-being of the communities in which we live. We are proud of our many employees who volunteer in the community and support them in many ways. By embracing corporate social responsibility as one of our basic operating principles, we have proved to be a true partner to communities across Croatia. Furthermore, we have reported sustainable development achievements for ten years in line with GRI guidelines, which cover economic, social and environmental performance indicators. We support projects of non-profit, non-governmental and charitable associations, and associations for persons with special needs. These funds are mostly intended for projects related to education, prevention of diseases and healthcare. Additionally, we continuously collaborate with Croatian universities, sponsor scholarship programs, support various scientific symposia, and our experts provide input on legal regulations in various fields. Our traditional ‘Walking to Health’ campaign, held on World Health Day, focuses on raising health awareness and promoting the benefits of everyday walking. Organized collection of expired medicines, carried out in cooperation with public health institutes, raises public awareness about medicinal products as waste requiring proper disposal and increases patient compliance.