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Basophils: Basophils are approximately the same size as neutrophils and eosinophils, but have large, strongly basophilic-specific granules that usually obstruct the appearance of the nucleus having two or three irregular lobes. (A and B): ×1500, Wright. (C) ×1500, Giemsa. (D) TEM of a sectioned basophil reveals the lobulated nucleus (N), appearing as three separated portions, the large specific basophilic granules (B), mitochondria (M), and Golgi complex (G). Basophils exert many activities modulating the immune response and inflammation and share many functions with mast cells, which are normal, longer term residents of connective tissue. ×16,000. Source: Mescher AL, Junqueira's Basic Histology text and Atlas 12th ed. McGraw Hill Lange New York 2010:211 (Figure 2-40D reproduced with permission from Terry RW et al. Lab Invest 1969;21:65, Chapter 12 Figure 12-10) Source: Cell Injury, Cell Death, and Aging, Pathology: A Modern Case Study Citation: Reisner HM. Pathology: A Modern Case Study; 2015 Available at: http://mhmedical.com/ Accessed: May 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved