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Table 1. Immunoexpression of ER A distribution, intensity and histoscore with grade of phyllodes tumor
Case Processing Summary
Cases
Valid
N
Missing
Percent
N
Total
Percent
N
Percent
Distribution_ER_A * grade
62
100,0%
0
0,0%
62
100,0%
Intensity__ER_A * grade
62
100,0%
0
0,0%
62
100,0%
Distribution ER_A * Grade
Crosstab
Grade
Benign
Count
0-20%
Expected Count
% within Grade
Count
Distribution ER_A
20-50%
Expected Count
% within Grade
Count
>50%
Expected Count
% within Grade
Count
Total
Expected Count
% within Grade
borederline
df
1
4
9
5,8
1,6
1,6
9,0
10,0%
9,1%
36,4%
14,5%
1
0
2
3
1,9
,5
,5
3,0
2,5%
0,0%
18,2%
4,8%
35
10
5
50
32,3
8,9
8,9
50,0
87,5%
90,9%
45,5%
80,6%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
100,0%
Asymp. Sig. (2sided)
11,500a
4
,021
Likelihood Ratio
9,777
4
,044
Linear-by-Linear Association
5,985
1
,014
Pearson Chi-Square
N of Valid Cases
62
a. 5 cells (55,6%) have expected count less than 5. The minimum expected
count is ,53.
Malignant
4
Chi-Square Tests
Value
Total
Symmetric Measures
Value
Asymp. Std.
Approx. Tb
Approx. Sig.
Errora
Interval by Interval
Pearson's R
-,313
,142
-2,555
,013c
Ordinal by Ordinal
Spearman Correlation
-,295
,139
-2,391
,020c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
NPar Tests
Two-Sample Kolmogorov-Smirnov Test
Frequencies
grade_1
Distribution_ER_A
Intensity__ER_A
N
Benign
40
borederline-malignant
22
Total
62
Benign
40
borederline-malignant
22
Total
62
Test Statisticsa
DistributionER_A
Intensity__ER_A
Absolute
,193
,423
Positive
,000
,000
Negative
-,193
-,423
Kolmogorov-Smirnov Z
,728
1,593
Asymp. Sig. (2-tailed)
,665
,013
Most Extreme Differences
a. Grouping Variable: kelompok_1
NPar Tests
Intensity__ER_A * Grade
Crosstab
Grade
Benign
Count
Weak
Expected Count
% within Grade
Count
Intensity_ER_A
Moderate
Expected Count
% within Grade
Count
Strong
Expected Count
% within Grade
Count
Total
Expected Count
% within Grade
borederline
df
1
5
10
6,5
1,8
1,8
10,0
10,0%
9,1%
45,5%
16,1%
10
6
5
21
13,5
3,7
3,7
21,0
25,0%
54,5%
45,5%
33,9%
26
4
1
31
20,0
5,5
5,5
31,0
65,0%
36,4%
9,1%
50,0%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
100,0%
Asymp. Sig. (2sided)
15,779a
4
,003
Likelihood Ratio
15,661
4
,004
Linear-by-Linear Association
12,584
1
,000
Pearson Chi-Square
N of Valid Cases
62
a. 4 cells (44,4%) have expected count less than 5. The minimum expected
count is 1,77.
Malignant
4
Chi-Square Tests
Value
Total
Symmetric Measures
Value
Approx. Tb
Asymp. Std.
Approx. Sig.
Errora
Interval by Interval
Pearson's R
-,454
,114
-3,949
,000c
Ordinal by Ordinal
Spearman Correlation
-,441
,112
-3,809
,000c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
Grade
Case Processing Summary
Grade
Cases
Valid
N
Histoscore_ER_A
Missing
Percent
N
Total
Percent
N
Percent
Benign
40
100,0%
0
0,0%
40
100,0%
borederline
11
100,0%
0
0,0%
11
100,0%
Malignant
11
100,0%
0
0,0%
11
100,0%
Descriptives
Group
Statistic
4,8000
Mean
95% Confidence Interval for
Mean
Lower Bound
4,2063
Upper Bound
5,3937
5% Trimmed Mean
5,0000
Median
6,0000
Variance
Benign
3,446
Std. Deviation
1,85638
Minimum
,00
Maximum
6,00
Range
6,00
Interquartile Range
2,00
Skewness
Kurtosis
Mean
95% Confidence Interval for
Mean
-1,489
1,170
4,0909
Lower Bound
2,8722
Upper Bound
5,3096
5% Trimmed Mean
4,1566
Median
4,0000
Variance
Histoscore_ER_A
borederline
1,81409
Minimum
1,00
Maximum
6,00
Range
5,00
Interquartile Range
4,00
Skewness
Kurtosis
Mean
Malignant
-,409
-1,075
2,3636
Lower Bound
1,0793
Upper Bound
3,6479
5% Trimmed Mean
2,2929
Median
2,0000
Variance
Std. Deviation
,661
1,279
,57640
3,655
1,91169
Minimum
,00
Maximum
6,00
Range
6,00
Interquartile Range
3,00
Skewness
Kurtosis
,374
,733
,54697
3,291
Std. Deviation
95% Confidence Interval for
Mean
Std. Error
,29352
,518
-,519
,661
1,279
Tests of Normality
Kolmogorov-Smirnova
Grade
Statistic
Histoscore_ER_A
df
Shapiro-Wilk
Sig.
Sig.
,366
40
,000
,678
40
,000
borederline
,217
11
,153
,859
11
,056
Malignant
,212
11
,181
,919
11
,307
Kruskal-Wallis Test
Ranks
grade_1
N
Mean Rank
benign
40
36,29
borederline-malignant
22
22,80
Total
62
Test Statisticsa,b
Histoscore_ER_A
Chi-Square
df
Benign
a. Lilliefors Significance Correction
Histoscore_ER_A
Statistic
9,144
df
Asymp. Sig.
a. Kruskal Wallis Test
b. Grouping Variable: grade_1
1
,002
Table 2 Immunoexpression of PR Distribution, Intensity and Histoscore with grade of phyllodes tumor
Case Processing Summary
Cases
Valid
N
Missing
Percent
N
Total
Percent
N
Percent
DistributionPR * Grade
62
100,0%
0
0,0%
62
100,0%
Intensity_PR * Grade
62
100,0%
0
0,0%
62
100,0%
Distribution_PR * Grade
Crosstab
Grade
Benign
Count
0-20%
Expected Count
% within grade
Count
Distribution_PR
20-50%
Expected Count
% within grade
Count
>50%
Expected Count
% within grade
Count
Total
Expected Count
% within grade
Total
borederline
Malignant
28
6
7
41
26,5
7,3
7,3
41,0
70,0%
54,5%
63,6%
66,1%
9
3
2
14
9,0
2,5
2,5
14,0
22,5%
27,3%
18,2%
22,6%
3
2
2
7
4,5
1,2
1,2
7,0
7,5%
18,2%
18,2%
11,3%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
100,0%
Chi-Square Tests
Value
df
Asymp. Sig. (2sided)
Pearson Chi-Square
Likelihood Ratio
Linear-by-Linear Association
1,960a
4
,743
1,896
4
,755
,932
1
,334
N of Valid Cases
62
a. 5 cells (55,6%) have expected count less than 5. The minimum expected
count is 1,24.
Symmetric Measures
Value
Asymp. Std.
Approx. Tb
Approx. Sig.
Errora
Interval by Interval
Pearson's R
,124
,133
,965
,339c
Ordinal by Ordinal
Spearman Correlation
,118
,130
,921
,361c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
NPar Tests
Two-Sample Kolmogorov-Smirnov Test
Frequencies
grade_1
Distribution_PR
Intensity_PR
N
benign
40
borederline-malignant
22
Total
62
benign
40
borederline-malignant
22
Total
62
Test Statisticsa
Distribution PR
Intensity_PR
Absolute
,109
,025
Positive
,109
,020
Negative
,000
-,025
Kolmogorov-Smirnov Z
,411
,094
Asymp. Sig. (2-tailed)
,996
1,000
Most Extreme Differences
a. Grouping Variable: grade_1
Intensity_PR * Group
Crosstab
Grade
Benign
Count
Weak
Moderate
11
60
38,7
10,6
10,6
60,0
97,5%
90,9%
100,0%
96,8%
Count
0
1
0
1
Expected Count
,6
,2
,2
1,0
0,0%
9,1%
0,0%
1,6%
Count
1
0
0
1
Expected Count
,6
,2
,2
1,0
2,5%
0,0%
0,0%
1,6%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
100,0%
Expected Count
% within grade
Count
Total
Expected Count
% within grade
Chi-Square Tests
Value
df
Asymp. Sig. (2sided)
Pearson Chi-Square
Likelihood Ratio
Linear-by-Linear Association
N of Valid Cases
5,239a
4
,264
4,389
4
,356
,120
1
,730
62
a. 6 cells (66,7%) have expected count less than 5. The minimum expected
count is ,18.
Malignant
10
% within grade
Strong
Borederline
39
% within grade
Intensitas_PR
Total
Symmetric Measures
Value
Approx. Tb
Asymp. Std.
Approx. Sig.
Errora
Interval by Interval
Pearson's R
Ordinal by Ordinal
Spearman Correlation
-,044
,073
-,343
,733c
,019
,108
,144
,886c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
Grade
Case Processing Summary
Grade
Cases
Valid
N
Histoscore_PR
Missing
Percent
N
Total
Percent
N
Percent
Benign
40
100,0%
0
0,0%
40
100,0%
borederline
11
100,0%
0
0,0%
11
100,0%
Malignant
11
100,0%
0
0,0%
11
100,0%
Descriptives
Grade
Statistic
,5000
Mean
95% Confidence Interval for
Mean
Benign
Lower Bound
,1603
Upper Bound
,8397
5% Trimmed Mean
,3333
Median
,0000
Variance
1,128
Std. Deviation
1,06217
Minimum
,00
Maximum
6,00
Range
6,00
Interquartile Range
1,00
Skewness
Kurtosis
Mean
95% Confidence Interval for
Mean
3,851
18,548
,8182
Lower Bound
,2311
Upper Bound
1,4053
5% Trimmed Mean
1,0000
Variance
borederline
,764
Std. Deviation
,87386
Minimum
,00
Maximum
2,00
Range
2,00
Interquartile Range
2,00
Skewness
Kurtosis
Mean
95% Confidence Interval for
Mean
Malignant
,409
-1,621
,6364
Lower Bound
,0928
Upper Bound
1,1799
5% Trimmed Mean
,5960
Median
,0000
Variance
Std. Deviation
,661
1,279
,24393
,655
,80904
Minimum
,00
Maximum
2,00
Range
2,00
Interquartile Range
1,00
Skewness
Kurtosis
,374
,733
,26348
,7980
Median
Histoscore_PR
Std. Error
,16794
,847
-,764
,661
1,279
Tests of Normality
Kolmogorov-Smirnova
Grade
Statistic
Histoscore_PR
df
Shapiro-Wilk
Sig.
df
Sig.
Benign
,356
40
,000
,501
40
,000
borederline
,280
11
,016
,785
11
,006
Malignant
,330
11
,001
,754
11
,002
a. Lilliefors Significance Correction
NPar Tests
Kruskal-Wallis Test
Ranks
grade_1
Histoscore_PR
Statistic
N
Mean Rank
benign
40
29,24
borederline-malignant
22
35,61
Total
62
Test Statisticsa,b
Histoscore_PR
Chi-Square
2,360
df
Asymp. Sig.
a. Kruskal Wallis Test
b. Grouping Variable: grade_1
1
,125
Tabel 3. Perbandingan WNTS Distribusi, Intensitas dan Histoskor dengan Gradasi
Case Processing Summary
Cases
Valid
N
Distibusi_WNTS *
kelompok_non
Intensitas_WNTS *
kelompok_non
Missing
Percent
N
Total
Percent
N
Percent
62
100,0%
0
0,0%
62
100,0%
62
100,0%
0
0,0%
62
100,0%
Distribusi_WNT5a
Crosstab
kelompok_non
Benign
Count
20-50%
Expected Count
% within kelompok_non
Total
Borederline
Malignant
5
0
0
5
3,2
,9
,9
5,0
12,5%
0,0%
0,0%
8,1%
35
11
11
57
36,8
10,1
10,1
57,0
87,5%
100,0%
100,0%
91,9%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
100,0%
Distibusi_WNT5a
Count
>50%
Expected Count
% within kelompok_non
Count
Total
Expected Count
% within kelompok_non
Chi-Square Tests
Value
df
Asymp. Sig. (2sided)
2,991a
2
,224
Likelihood Ratio
4,621
2
,099
Linear-by-Linear Association
2,511
1
,113
Pearson Chi-Square
N of Valid Cases
62
a. 3 cells (50,0%) have expected count less than 5. The minimum expected
count is ,89.
Symmetric Measures
Value
Approx. Tb
Asymp. Std.
Approx. Sig.
Errora
Interval by Interval
Pearson's R
,203
,049
1,605
,114c
Ordinal by Ordinal
Spearman Correlation
,214
,051
1,701
,094c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
Intensitas_WNT5a
Crosstab
kelompok_non
Benign
Count
lemah
Expected Count
% within kelompok_non
Count
Intensitas_WNT5a
sedang
Expected Count
% within kelompok_non
Count
kuat
Expected Count
% within kelompok_non
Count
Total
Expected Count
% within kelompok_non
Borederline
df
0
0
3
1,9
,5
,5
3,0
7,5%
0,0%
0,0%
4,8%
7
0
1
8
5,2
1,4
1,4
8,0
17,5%
0,0%
9,1%
12,9%
30
11
10
51
32,9
9,0
9,0
51,0
75,0%
100,0%
90,9%
82,3%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
100,0%
Asymp. Sig. (2sided)
4,625a
4
,328
Likelihood Ratio
6,950
4
,139
Linear-by-Linear Association
2,876
1
,090
Pearson Chi-Square
N of Valid Cases
62
a. 5 cells (55,6%) have expected count less than 5. The minimum expected
count is ,53.
Malignant
3
Chi-Square Tests
Value
Total
Symmetric Measures
Value
Asymp. Std.
Approx. Tb
Approx. Sig.
Errora
Interval by Interval
Pearson's R
,217
,080
1,723
,090c
Ordinal by Ordinal
Spearman Correlation
,239
,095
1,905
,062c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
Two-Sample Kolmogorov-Smirnov Test
Frequencies
Kelompok_2
Distibusi_WNT5a
Intensitas_WNT5a
N
Benign
40
borederline-malignant
22
Total
62
Benign
40
borederline-malignant
22
Total
62
Test Statisticsa
Distibusi_WNTS
Intensitas_WNTS
Absolute
,125
,205
Positive
,125
,205
Negative
,000
,000
Kolmogorov-Smirnov Z
,471
,771
Asymp. Sig. (2-tailed)
,980
,593
Most Extreme Differences
a. Grouping Variable: Kelompok_2
Histoskor_WNTS is constant when kelompok_non = Borederline. It will be
included in any boxplots produced but other output will be omitted.
kelompok_non
Cases
Valid
N
Histoskor_WNT5a
Missing
Percent
N
Total
Percent
N
Percent
Benign
40
100,0%
0
0,0%
40
100,0%
Borederline
11
100,0%
0
0,0%
11
100,0%
Malignant
11
100,0%
0
0,0%
11
100,0%
Descriptivesa
kelompok_non
Statistic
Mean
5,1500
Lower
95% Confidence Interval for
Bound
Mean
Upper
Bound
Benign
5,6649
5,3333
Median
6,0000
2,592
Std. Deviation
Histoskor_WNT5a
1,61006
Minimum
1,00
Maximum
6,00
Range
5,00
Interquartile Range
1,50
Skewness
Kurtosis
Mean
Lower
95% Confidence Interval for
Bound
Mean
Upper
Malignant
Bound
-1,653
,374
1,248
,733
5,8182
,18182
5,4131
6,2233
5% Trimmed Mean
5,9091
Median
6,0000
Variance
,25457
4,6351
5% Trimmed Mean
Variance
Std. Error
,364
Std. Deviation
,60302
Minimum
4,00
Maximum
6,00
Range
2,00
Interquartile Range
,00
Skewness
Kurtosis
Tests of
-3,317
,661
11,000
1,279
Normalityb
Kolmogorov-Smirnova
kelompok_non
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
Benign
,451
40
,000
,577
40
,000
Malignant
,528
11
,000
,345
11
,000
Histoskor_WNTS
a. Lilliefors Significance Correction
b. Histoskor_WNTS is constant when kelompok_non = Borederline. It has been omitted.
Kruskal-Wallis Test
Ranks
Kelompok_2
Histoskor_WNT5a
N
Mean Rank
Benign
40
29,18
borederline-malignant
22
35,73
Total
62
Test Statisticsa,b
Histoskor_WNT5a
Chi-Square
4,229
df
Asymp. Sig.
1
,040
a. Kruskal Wallis Test
b. Grouping Variable: Kelompok_2
Tabel 4. Perbandingan HMGA Distribusi, Intensitas dan Histoskor dengan Gradasi
Cases
Valid
N
Missing
Percent
N
Percent
Total
N
Percent
Distribusi_HMGA *
kelompok_non
Intensitas_HMGA *
kelompok_non
62
100,0%
0
0,0%
62
100,0%
62
100,0%
0
0,0%
62
100,0%
Distribusi_HMGA
Crosstab
kelompok_non
Benign
20-50%
Borederline
Total
Malignant
Count
13
0
0
13
Expected Count
8,4
2,3
2,3
13,0
32,5%
0,0%
0,0%
21,0%
27
11
11
49
31,6
8,7
8,7
49,0
67,5%
100,0%
100,0%
79,0%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
100,0%
% within kelompok_non
Distribusi_HMGA
Count
>50%
Expected Count
% within kelompok_non
Count
Total
Expected Count
% within kelompok_non
Chi-Square Tests
Value
df
Asymp. Sig. (2sided)
Pearson Chi-Square
9,047
a
2
,011
Likelihood Ratio
13,231
2
,001
7,593
1
,006
Linear-by-Linear Association
N of Valid Cases
62
a. 2 cells (33,3%) have expected count less than 5. The minimum expected
count is 2,31.
Symmetric Measures
Value
Asymp. Std.
Approx. Tb
Approx. Sig.
Errora
Interval by Interval
Pearson's R
,353
,056
2,921
,005c
Ordinal by Ordinal
Spearman Correlation
,373
,059
3,114
,003c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
Two-Sample Kolmogorov-Smirnov Tes
Frequencies
Kelompok_2
Distribusi_HMGA
Intensitas_HMGA
N
Benign
40
borederline-malignant
22
Total
62
Benign
40
borederline-malignant
22
Total
62
Test Statisticsa
Most Extreme Differences
Distribusi_HMGA
Intensitas_HMGA
Absolute
,325
,339
Positive
,325
,339
Negative
,000
,000
1,224
1,276
,100
,077
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: Kelompok_2
Intensitas_HMGA
Crosstab
kelompok_non
Benign
Borederline
Malignant
7
1
0
8
5,2
1,4
1,4
8,0
17,5%
9,1%
0,0%
12,9%
Count
12
2
0
14
Expected Count
9,0
2,5
2,5
14,0
Count
lemah
Intensitas_HMGA
Total
Expected Count
% within kelompok_non
sedang
% within kelompok_non
30,0%
18,2%
0,0%
22,6%
21
8
11
40
25,8
7,1
7,1
40,0
52,5%
72,7%
100,0%
64,5%
40
11
11
62
40,0
11,0
11,0
62,0
100,0%
100,0%
100,0%
Count
kuat
Expected Count
% within kelompok_non
Count
Expected Count
Total
% within kelompok_non
100,0
%
Chi-Square Tests
Value
df
Asymp. Sig. (2sided)
Pearson Chi-Square
8,908a
4
,063
Likelihood Ratio
12,420
4
,014
7,413
1
,006
Linear-by-Linear Association
N of Valid Cases
62
a. 4 cells (44,4%) have expected count less than 5. The minimum expected
count is 1,42.
Symmetric Measures
Value
Asymp. Std.
Approx. Tb
Approx. Sig.
Errora
Interval by Interval
Pearson's R
,349
,075
2,881
,005c
Ordinal by Ordinal
Spearman Correlation
,361
,091
2,999
,004c
N of Valid Cases
62
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
c. Based on normal approximation.
Warnings
Histoskor_HMGA is constant when kelompok_non = Malignant. It will be
included in any boxplots produced but other output will be omitted.
Histoskor HMGA
Case Processing Summary
kelompok_non
Cases
Valid
N
Histoskor_HMGA
Missing
Percent
N
Total
Percent
N
Percent
Benign
40
100,0%
0
0,0%
40 100,0%
Borederline
11
100,0%
0
0,0%
11 100,0%
Malignant
11
100,0%
0
0,0%
11 100,0%
Descriptivesa
kelompok_non
Statistic
Std.
Error
Mean
4,0250
95% Confidence Interval for
Lower Bound
3,3958
Mean
Upper Bound
4,6542
5% Trimmed Mean
4,0833
Median
4,0000
Variance
Benign
,31109
3,871
Std. Deviation
1,96752
Minimum
1,00
Maximum
6,00
Range
5,00
Interquartile Range
4,00
Skewness
-,207
,374
Kurtosis
-1,688
,733
Mean
5,2727
,40656
Histoskor_HMGA
Borederline
95% Confidence Interval for
Lower Bound
4,3669
Mean
Upper Bound
6,1786
5% Trimmed Mean
5,4141
Median
6,0000
Variance
Std. Deviation
1,818
1,34840
Minimum
2,00
Maximum
6,00
Range
4,00
Interquartile Range
2,00
Skewness
Kurtosis
-1,800
,661
2,611
1,279
a. Histoskor_HMGA is constant when kelompok_non = Malignant. It has been omitted.
Tests of Normalityb
kelompok_non
Kolmogorov-Smirnova
Statistic
Df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
Benign
,292
40
,000
,794
40
,000
Borederline
,432
11
,000
,619
11
,000
Histoskor_HMGA
a. Lilliefors Significance Correction
b. Histoskor_HMGA is constant when kelompok_non = Malignant. It has been omitted.
Kruskal-Wallis Test
Ranks
Kelompok_2
Histoskor_HMGA
40
26,58
borederline-malignant
22
40,45
Total
62
Histoskor_HMGA
df
Asymp. Sig.
Mean Rank
Benign
Test Statisticsa,b
Chi-Square
N
10,766
1
,001
a. Kruskal Wallis Test
b. Grouping Variable: Kelompok_2