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Monday, 26.05.2014 Time PIs (speaker in bold) Project Title 10:00 - 10:15 Welcome and Progress report of the SFB/TRR77 (Schirmacher) 10:15 - 10:29 Bartenschlager, Ralf Lohmann, Volker - 10:43 Pietschmann, Thomas Haid, Sibylle - 10:57 Herzig, Stephan Berriel-Diaz, Mauricio - 11:11 Straub, Beate K. - 11:25 Wuestefeld, Torsten - 11:39 Balakrishnan, Asha - 11:53 Vogel, Arndt - 12:07 Angel, Peter Heß, Jochen - 12:21 Mederacke, Ingmar Molecular mechanisms of pro-carcinogenic alterations and HCC development induced by hepatotropic viruses Hepatitis C virus cell entry factor usage in Hepatitis C progression and liver carcinogenesis Characterization of pathways contributing to the metabolic etiology of HCC Lipid droplets and associated proteins in chronic liver diseases and hepatocarcinogenesis Functional genetic dissection of NASH induced hepatocarcinogenesis Interactions between signaling, metabolic pathways and miRNAs in HCC Role of c-myc in Chronic Liver Injury and Liver Cancer Function of HMGB1-RAGE signaling in inflammation-associated liver carcinogenesis Role of hepatic stellate cells in liver metastasis 12:30 - 13:30 Lunch break - 13:44 Schulze-Osthoff, Klaus Hailfinger, Stephan - 13:58 Breuhahn, Kai - 14:12 Longerich, Thomas Pellegrino, Rossella - 14:26 Malek, Nisar Role of atypical nuclear IκB proteins in HCC formation Gain of function mechanisms of transcriptional regulators in tumor initiation and progression Protumorigenic function of EEF1A2 in human HCC Role of centrosome duplication defects in the pathogenesis of HCC - 14:40 Singer, Stephan Nuclear pore complex (NPC) composition in hepatocarcinogenesis - 14:54 Nordheim, Alfred - 15:08 Rössler, Stephanie Mechanisms of HCC tumor suppression Tumor suppressor genes in human hepatocellular carcinoma: Link to inflammation Functional consequences of epigenetic regulated tumour suppressor miRNA-449 family in HCC - 15:22 Skawran, Britta Schlegelberger, Brigitte 15:25 - 15:50 Coffee break - 16:04 Bitzer Michael Salih, Helmut R. - 16:18 Kossatz-Böhlert, Uta - 16:32 - 16:46 - 17:00 - 17:24 17:30 - 18:30 Epigenetic priming of liver tumors for induction of NK cell immunity Functional and phenotypic regulators of hepatic progenitor cells in dependence of the mTORC1 kinase complex Longerich, Thomas Comprehensive characterization of HCC-CC Bermejo, Justo Lorenzo Integrative assessment of epigenetic and genetic changes in gallbladder cancer development Goeppert, Benjamin Genetic and epigenetic characterization of cholangiocarcinoma Weichenhan, Dieter Zender, Lars Induction of hepatocyte - cholagiocyte transdifferentiation as a Zieker, Derek therapeutic strategy to treat bile duct disease Report of the gerok stipends (Geraud (i.A. Koch), Holzer, Goeppert, Waldburger) 18:30 - 19:30 SFB/TRR77 key structure status and perspective 19:30h Dinner Tuesday, 27.05.2014 Time PIs (speaker in bold) Project Title 7:30 – 8:30 Breakfast; Steering Committee meeting 8:30 - 8:44 Bantel, Heike Lehner, Frank Schulze-Osthoff, Klaus - 8:58 Dooley, Steven Ebert, Matthias Meindl-Beinker, Nadja Hopf, Carsten - 9:12 Wirth, Thomas - 9:26 Lauer, Ulrich M. - 9:40 Woller, Norman - 9:54 Gürlevik, Engin - 10:08 Kühnel, Florian Kubicka, Stefan - 10:22 Yevsa, Tetyana - 10:36 Goerdt, Sergeij Augustin, Hellmut - 10:50 Saborowski, Anna Saborowski, Michael Tumor-targeted TRAIL fusion proteins as novel treatment strategy for hepatocellular carcinoma TGF- signaling (inhibition) on targeted treatment response in HCC TGF- signaling (inhibition) on targeted treatment response in HCC Development of co-stimulation assisted T cell vaccinations for the therapy of liver cancers Signaling Pattern Virograms (SPV) for personalization & optimization of HCC Virotherapy Enhancement of systemic neo-epitope (mutanom) responsiveness of cytotoxic T cells by interference of localized oncolytic infection and tumor vaccination. Immunoepitope dynamics in liver cancer during resection, dormancy and recurrence as a basis for tailored tumor therapies Targeting the mutanome of HCC by viral inflammation and tumordirected vaccinations: a model for individualized tumor therapy Investigation of therapy‐induced senescence and concomitant immune response in metastatic liver cancer (model) HCC and the hepatic vascular niche: Analysis of angiocrine and adhesive vascular targets A negative selection shRNA screen for targeted combination therapy in cholangiocarcinoma 10:50 - 11:10 Coffee break and group picture 11:10 - 12:10 Relaunch: structure, timeline, discussion 12:10 - 13:10 Further HCC activities - 13:15 Closing remarks Lunch break and Steering Committee meeting