Download Angiotensin II - Quest Diagnostics

Angiotensin II
36718X
Clinical Use
• Differential diagnosis of renal
hypertension
Reference Range
Adults
Clinical Background
Angiotensin II is the primary regulator
of renal aldosterone secretion and a
potent vasoconstrictor. It is generated
through the renin angiotensin system
(RAS): circulating angiotensinogen is
cleaved by renin to form angiotensin I,
which is then converted to angiotensin
II via angiotensin converting enzyme
(ACE). The rate-limiting step in the
RAS is renin secretion by the renal
juxtaglomerular cells, modulated by
renal blood flow. Low renal blood flow
and low perfusion pressure increases
renin secretion, stimulating angiotensin II and aldosterone production
with a resulting increase in blood
pressure and renal sodium retention.
These changes then produce
inhibition of renin secretion and
complete the feedback control loop.
10-50 ng/L
Interpretive Information
• High renin hypertension
• Renin-secreting juxtaglomerular renal tumor
• Volume depletion
• Congestive heart failure
• Cirrhosis
• Angiotensin II receptor blocking
drug therapy
•
•
•
•
Anephric patients
Primary aldosteronism
Cushing's syndrome
ACE inhibitor therapy
Method
• Radioimmunoassay (RIA)
Specimen Requirements
1 mL frozen EDTA plasma
0.3 mL minimum
26