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S3 Table. Genes up-regulated by 20 µM Zn treatment ID SAUSA300_0055 SAUSA300_0067 SAUSA300_0070 SAUSA300_0078 SAUSA300_0079 SAUSA300_0107 SAUSA300_0108 SAUSA300_0127 SAUSA300_0183 SAUSA300_0205 SAUSA300_0206 SAUSA300_0208 SAUSA300_0228 SAUSA300_0229 SAUSA300_0231 SAUSA300_0232 SAUSA300_0233 SAUSA300_0234 SAUSA300_0245 SAUSA300_0246 SAUSA300_0247 SAUSA300_0253 SAUSA300_0261 SAUSA300_0271 SAUSA300_0272 SAUSA300_0273 SAUSA300_0274 SAUSA300_0277 SAUSA300_0278 SAUSA300_0279 SAUSA300_0282 SAUSA300_0288 SAUSA300_0289 SAUSA300_0298 SAUSA300_0299 SAUSA300_0300 Name copA fadE scdA Fold Change 2.88 1.85 1.41 2.58 2.22 1.63 1.94 1.98 1.82 1.52 1.59 p value 0.0000 0.0000 0.0217 0.0000 0.0000 0.0030 0.0000 0.0003 0.0000 0.0383 0.0000 1.44 2.37 3.09 2.28 4.75 3.59 4.64 0.0080 0.0000 0.0000 0.0000 0.0000 0.0004 0.0000 1.73 1.30 1.24 3.08 1.44 1.81 1.83 2.39 2.59 1.62 1.60 1.41 1.69 1.27 1.34 1.87 1.99 1.76 0.0000 0.0062 0.0415 0.0000 0.0247 0.0031 0.0084 0.0066 0.0000 0.0011 0.0000 0.0325 0.0175 0.0169 0.0097 0.0123 0.0149 0.0343 Gene product alcohol dehydrogenase zinc-containing universal stress protein family putative lysophospholipase ATPase copper transport putative lipoprotein Na/Pi cotransporter family protein antigen 67 kDa conserved hypothetical protein conserved hypothetical protein staphylococcal tandem lipoprotein flavodoxin family protein putative maltose ABC transporter ATP-binding protein acyl-CoA synthetase FadE putative acyl-CoA transferase FadX ABC transporter substrate-binding protein conserved hypothetical protein conserved hypothetical protein putative flavohemoprotein 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase putative alcohol dehydrogenase putative teichoic acid biosynthesis protein B ScdA protein conserved hypothetical protein ABC transporter ATP-binding protein conserved hypothetical protein putative membrane protein conserved hypothetical protein putative staphyloxanthin biosynthesis protein conserved hypothetical protein putative membrane protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein SAUSA300_0301 SAUSA300_0303 SAUSA300_0304 SAUSA300_0305 SAUSA300_0308 SAUSA300_0309 SAUSA300_0310 SAUSA300_0317 SAUSA300_0329 SAUSA300_0374 SAUSA300_0381 SAUSA300_0385 SAUSA300_0393 SAUSA300_0394 SAUSA300_0413 SAUSA300_0419 SAUSA300_0420 SAUSA300_0421 SAUSA300_0422 SAUSA300_0445 SAUSA300_0461 SAUSA300_0466 SAUSA300_0469 SAUSA300_0470 SAUSA300_0474 SAUSA300_0490 SAUSA300_0506 SAUSA300_0507 SAUSA300_0508 SAUSA300_0509 SAUSA300_0510 SAUSA300_0513 SAUSA300_0514 SAUSA300_0515 SAUSA300_0516 SAUSA300_0517 SAUSA300_0518 SAUSA300_0519 SAUSA300_0521 SAUSA300_0526 pfoR gltB holB ksgA hslO nupC ctsR clpC gltX cysE cysS cysS nusG 1.65 1.56 1.65 1.60 2.25 2.04 1.57 1.86 1.35 1.52 1.56 1.56 2.10 0.0003 0.0160 0.0094 0.0028 0.0000 0.0000 0.0000 0.0003 0.0346 0.0141 0.0000 0.0002 0.0085 2.02 2.09 1.96 2.11 1.66 1.56 1.34 1.55 1.44 1.35 1.36 1.38 1.36 1.37 2.38 2.13 2.14 1.94 1.43 1.63 1.62 1.63 1.57 1.64 1.84 0.0000 0.0180 0.0000 0.0000 0.0001 0.0056 0.0045 0.0014 0.0120 0.0371 0.0075 0.0013 0.0084 0.0002 0.0000 0.0000 0.0000 0.0000 0.0012 0.0000 0.0000 0.0000 0.0001 0.0000 0.0000 1.30 1.48 0.0019 0.0009 conserved hypothetical protein putative lipoprotein conserved hypothetical protein formate nitrite transporter family protein ABC transporter permease protein ABC transporter ATP-binding protein perfringolysin O regulator protein conserved hypothetical protein putative oxidoreductase putative membrane protein putative NAD(P)H-flavin oxidoreductase conserved hypothetical protein conserved hypothetical protein FAD/NAD(P)-binding Rossmann fold Superfamily staphylococcal tandem lipoprotein staphylococcal tandem lipoprotein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein glutamate synthase large subunit DNA polymerase III delta subunit conserved hypothetical protein primase-related protein dimethyladenosine transferase putative endoribonuclease L-PSP Heat shock protein 33-like protein pyrimidine nucleoside transport protein transcriptional regulator CtsR conserved hypothetical protein ATP guanido phosphotransferase endopeptidase glutamyl-tRNA synthetase serine acetyltransferase cysteinyl-tRNA synthetase conserved hypothetical protein RNA methyltransferase conserved hypothetical protein conserved hypothetical protein transcription termination antitermination factor NusG Methyltransferase small domain SAUSA300_0529 SAUSA300_0530 SAUSA300_0531 SAUSA300_0532 SAUSA300_0547 SAUSA300_0550 SAUSA300_0555 SAUSA300_0556 SAUSA300_0558 SAUSA300_0563 SAUSA300_0564 SAUSA300_0573 SAUSA300_0574 SAUSA300_0576 SAUSA300_0577 SAUSA300_0579 SAUSA300_0580 SAUSA300_0581 SAUSA300_0589 SAUSA300_0590 SAUSA300_0594 SAUSA300_0597 SAUSA300_0604 SAUSA300_0605 SAUSA300_0609 SAUSA300_0610 SAUSA300_0613 SAUSA300_0626 SAUSA300_0627 SAUSA300_0628 SAUSA300_0636 SAUSA300_0637 SAUSA300_0638 SAUSA300_0639 SAUSA300_0643 SAUSA300_0647 SAUSA300_0648 SAUSA300_0652 SAUSA300_0657 SAUSA300_0658 rpsL fusA sdrD ung mvaD adh sarA tagB tagX 1.29 1.39 1.33 1.34 1.55 1.70 1.30 1.35 1.85 1.43 1.39 1.52 1.39 0.0375 0.0011 0.0027 0.0020 0.0002 0.0000 0.0250 0.0235 0.0000 0.0039 0.0189 0.0003 0.0033 1.88 3.71 1.71 1.64 1.56 2.07 1.46 1.42 2.05 1.68 1.50 2.00 1.76 1.87 1.41 1.49 1.37 1.67 1.54 1.57 1.28 1.74 2.05 1.57 1.34 1.33 1.38 0.0000 0.0000 0.0000 0.0176 0.0056 0.0000 0.0006 0.0233 0.0008 0.0002 0.0155 0.0038 0.0003 0.0009 0.0020 0.0007 0.0161 0.0000 0.0032 0.0010 0.0101 0.0000 0.0006 0.0153 0.0152 0.0035 0.0022 conserved hypothetical protein ribosomal protein S12 30S ribosomal protein S7 translation elongation factor G sdrD protein glycosyl transferase group 1 family protein putative hexulose-6-phosphate synthase SIS domain protein putative proline/betaine transporter uracil-DNA glycosylase conserved hypothetical protein diphosphomevalonate decarboxylase phosphomevalonate kinase putative Pyridine nucleotide-disulphide oxidoreductase putative transcriptional regulator conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein aldo/keto reductase family protein conserved hypothetical protein alcohol dehydrogenase putative endonuclease III hydrolase alpha/beta hydrolase fold family staphylococcal accessory regulator A phage integrase family protein putative Na+:H+ antiporter MnhA component putative Na+:H+ antiporter MnhD component teichoic acid biosynthesis protein B teichoic acid biosynthesis protein X teichoic acid biosynthesis protein D dihydroxyacetone kinase DhaK subunit dihydroxyacetone kinase DhaL subunit dihydroxyacetone kinase phosphotransfer subunit conserved hypothetical protein acetyltransferase GNAT family ABC transporter ATP-binding protein ABC transporter permease protein putative membrane protein conserved hypothetical protein transcriptional regulator LysR family SAUSA300_0664 SAUSA300_0668 1.31 1.36 0.0364 0.0246 SAUSA300_0670 1.46 0.0001 SAUSA300_0671 SAUSA300_0676 SAUSA300_0677 SAUSA300_0679 SAUSA300_0680 SAUSA300_0682 SAUSA300_0684 SAUSA300_0685 SAUSA300_0686 SAUSA300_0688 SAUSA300_0689 SAUSA300_0708 SAUSA300_0711 SAUSA300_0726 SAUSA300_0740 SAUSA300_0747 1.32 1.48 1.34 1.67 1.45 1.57 1.39 1.47 1.45 1.70 1.35 1.66 1.49 1.69 1.35 1.78 0.0105 0.0010 0.0289 0.0085 0.0026 0.0076 0.0160 0.0079 0.0014 0.0001 0.0258 0.0021 0.0036 0.0000 0.0095 0.0000 2.01 1.65 1.91 2.73 2.53 0.0000 0.0001 0.0002 0.0002 0.0015 2.43 1.69 1.36 1.30 1.40 2.19 2.34 1.58 1.40 1.85 1.58 1.27 1.34 1.27 0.0043 0.0000 0.0005 0.0104 0.0360 0.0000 0.0000 0.0114 0.0165 0.0217 0.0003 0.0065 0.0057 0.0267 norA ybaK fruB fruA nagA hisC trxB SAUSA300_0752 SAUSA300_0755 SAUSA300_0756 SAUSA300_0757 SAUSA300_0758 clpP SAUSA300_0759 SAUSA300_0760 SAUSA300_0764 SAUSA300_0765 SAUSA300_0768 SAUSA300_0769 SAUSA300_0772 SAUSA300_0786 SAUSA300_0793 SAUSA300_0805 SAUSA300_0817 SAUSA300_0818 SAUSA300_0819 SAUSA300_0820 gpmI eno rnr smpB gap pgk tpiA clfA sufC sufD sufS conserved hypothetical protein conserved hypothetical protein ABC transporter ATP-binding protein MsbA family ABC transporter ATP-binding protein MsbA family anion transporter family protein putative deoxyribodipyrimidine photolyase conserved hypothetical protein multi drug resistance protein ybaK/ebsC protein fructose 1-phosphate kinase fructose specific permease N-acetylglucosamine-6-phosphate deacetylase oxidoreductase aldo/keto reductase family glycosyl transferase group 2 family protein histidinol-phosphate aminotransferase conserved hypothetical protein glycerate kinase family protein conserved hypothetical protein thioredoxin-disulfide reductase ATP-dependent Clp protease proteolytic subunit ClpP glycolytic operon regulator glyceraldehyde-3-phosphate dehydrogenase type I phosphoglycerate kinase triosephosphate isomerase 23-bisphosphoglycerate-independent phosphoglycerate mutase phosphopyruvate hydratase ribonuclease R SsrA-binding protein conserved hypothetical protein putative lipoprotein clumping factor A OsmC/Ohr family protein conserved hypothetical protein pathogenicity island protein putative membrane protein FeS assembly ATPase SufC FeS assembly protein SufD cysteine desulfurases SufS subfamily subfamily SAUSA300_0826 SAUSA300_0827 SAUSA300_0828 SAUSA300_0832 SAUSA300_0833 SAUSA300_0834 SAUSA300_0842 SAUSA300_0844 SAUSA300_0855 SAUSA300_0859 SAUSA300_0860 SAUSA300_0861 SAUSA300_0869 SAUSA300_0870 SAUSA300_0874 SAUSA300_0877 SAUSA300_0883 SAUSA300_0885 SAUSA300_0886 SAUSA300_0887 SAUSA300_0888 fabH fabF oppB oppC 1.58 1.44 1.30 1.46 1.55 1.27 1.41 1.23 1.31 1.97 1.72 1.41 1.53 1.34 1.38 3.19 1.72 1.51 1.69 1.96 2.09 0.0000 0.0006 0.0078 0.0001 0.0000 0.0106 0.0002 0.0293 0.0037 0.0000 0.0001 0.0126 0.0000 0.0032 0.0186 0.0000 0.0000 0.0001 0.0000 0.0001 0.0000 SAUSA300_0889 oppD 2.09 0.0000 SAUSA300_0890 oppF 1.95 0.0001 SAUSA300_0891 oppA 1.82 0.0001 SAUSA300_0892 SAUSA300_0903 SAUSA300_0904 SAUSA300_0906 SAUSA300_0907 SAUSA300_0908 SAUSA300_0909 SAUSA300_0910 oppA 1.89 1.52 1.52 1.60 1.49 1.35 1.63 1.56 0.0012 0.0004 0.0002 0.0000 0.0000 0.0001 0.0000 0.0000 1.40 1.33 1.91 1.31 1.35 0.0002 0.0015 0.0000 0.0247 0.0133 SAUSA300_0911 SAUSA300_0912 SAUSA300_0914 SAUSA300_0917 SAUSA300_0918 mnhA rocD gudB rexB rexA clpB mgtE conserved hypothetical protein putative membrane protein 5'-nucleotidase family protein conserved hypothetical protein conserved hypothetical protein D-isomer specific 2-hydroxyacid dehydrogenase conserved hypothetical protein conserved hypothetical protein Na/H+ antiporter subunit A NADH-dependent flavin oxidoreductase Ornithine aminotransferase NAD-specific glutamate dehydrogenase exonuclease RexB exonuclease RexA conserved hypothetical protein Chaperone clpB putative surface protein 3-oxoacyl-(acyl-carrier-protein) synthase III 3-oxoacyl-(acyl-carrier-protein) synthase II oligopeptide ABC transporter permease protein oligopeptide ABC transporter permease protein oligopeptide ABC transporter ATP-binding protein oligopeptide ABC transporter ATP-binding protein oligopeptide ABC transporter substrate-binding protein oligopeptide ABC transporter oligopeptidebinding protein conserved hypothetical protein protozoan/cyanobacterial globin family protein conserved hypothetical protein GTP pyrophosphokinase NAD+/NADH kinase pseudouridine synthases RluA subfamily magnesium transporter transporter monovalent cation:proton antiporter-2 (CPA2) family protein trans-2-enoyl-ACP reductase sodium:alanine symporter family protein putative membrane protein conserved hypothetical protein SAUSA300_0923 SAUSA300_0925 SAUSA300_0930 SAUSA300_0934 SAUSA300_0936 SAUSA300_0940 SAUSA300_0943 htrA 1.48 1.48 1.62 2.14 1.92 1.99 1.96 0.0061 0.0001 0.0005 0.0000 0.0017 0.0001 0.0000 SAUSA300_0946 SAUSA300_0947 SAUSA300_0960 SAUSA300_0961 SAUSA300_0962 SAUSA300_0963 SAUSA300_0970 SAUSA300_0971 SAUSA300_0972 SAUSA300_0981 SAUSA300_0982 SAUSA300_0983 SAUSA300_0984 SAUSA300_0986 SAUSA300_0987 menD menD qoxD qoxC qoxB qoxA purQ purL purF 1.32 1.36 1.42 1.63 1.60 1.65 1.56 1.50 1.40 1.28 1.78 1.30 1.27 2.33 2.39 0.0032 0.0025 0.0126 0.0000 0.0000 0.0000 0.0169 0.0097 0.0136 0.0306 0.0000 0.0026 0.0056 0.0000 0.0000 SAUSA300_0993 pdhA 1.57 0.0000 SAUSA300_0994 SAUSA300_0995 SAUSA300_0996 pdhB 1.53 1.49 1.47 0.0000 0.0000 0.0000 SAUSA300_1002 SAUSA300_1007 SAUSA300_1009 SAUSA300_1016 SAUSA300_1017 SAUSA300_1042 SAUSA300_1043 SAUSA300_1045 SAUSA300_1049 potD 1.36 1.27 1.55 1.72 1.77 1.27 1.48 1.53 1.42 0.0055 0.0083 0.0110 0.0000 0.0000 0.0272 0.0000 0.0003 0.0017 1.43 0.0016 SAUSA300_1050 ptsH ptsI lpdA typA cyoE mutS2 uvrC murI serine protease 5' nucleotidase family protein lipoate-protein ligase A family protein membrane protein ABC transporter ATP-binding protein conserved hypothetical protein acetyltransferase GNAT family family 2-succinyl-6-hydroxy-24-cyclohexadiene-1carboxylic acid synthase/2-oxoglutarate decarboxylase hydrolase alpha/beta hydrolase fold family quinol oxidase subunit IV quinol oxidase subunit III quinol oxidase subunit I quinol oxidase subunit II phosphoribosylformylglycinamidine synthase I phosphoribosylformylglycinamidine synthase II amidophosphoribosyltransferase conserved hypothetical protein conserved hypothetical protein phosphocarrier protein HPr phosphoenolpyruvate-protein phosphotransferase cytochrome D ubiquinol oxidase subunit I cytochrome D ubiquinol oxidase subunit II pyruvate dehydrogenase E1 component alpha subunit pyruvate dehydrogenase E1 component beta subunit dihydrolipoamide acetyltransferase dihydrolipoamide dehydrogenase spermidine/putrescine ABC transporter spermidine/putrescine-binding protein inositol monophosphatase family protein GTP-binding protein protoheme IX farnesyltransferase conserved hypothetical protein DNA-dependent DNA polymerase family X DNA mismatch repair MutS2 protein excinuclease ABC C subunit glutamate racemase non-canonical purine NTP pyrophosphatase rdgB/HAM1 family SAUSA300_1051 SAUSA300_1072 SAUSA300_1073 SAUSA300_1074 SAUSA300_1075 mraZ mraW ftsL pbpA 1.28 3.47 3.07 1.78 2.19 0.0192 0.0000 0.0000 0.0000 0.0000 SAUSA300_1076 mraY 2.16 0.0000 SAUSA300_1077 SAUSA300_1078 SAUSA300_1079 SAUSA300_1080 SAUSA300_1100 murD divIB ftsA ftsZ 2.50 2.10 1.42 1.39 1.24 0.0000 0.0000 0.0000 0.0003 0.0284 SAUSA300_1104 coaBC SAUSA300_1106 SAUSA300_1108 def SAUSA300_1109 fmt 1.46 1.83 1.32 1.56 0.0002 0.0000 0.0278 0.0000 SAUSA300_1110 SAUSA300_1111 SAUSA300_1112 SAUSA300_1113 SAUSA300_1119 SAUSA300_1120 SAUSA300_1123 SAUSA300_1124 SAUSA300_1127 SAUSA300_1143 SAUSA300_1144 SAUSA300_1145 SAUSA300_1146 SAUSA300_1147 1.48 1.42 1.51 1.36 1.52 1.29 1.26 1.33 1.32 1.50 1.57 1.70 1.62 1.44 0.0001 0.0008 0.0000 0.0008 0.0011 0.0102 0.0470 0.0118 0.0271 0.0008 0.0000 0.0000 0.0000 0.0000 1.51 1.24 1.28 1.48 1.35 1.28 1.31 0.0000 0.0304 0.0107 0.0007 0.0013 0.0089 0.0346 SAUSA300_1148 SAUSA300_1156 SAUSA300_1159 SAUSA300_1160 SAUSA300_1161 SAUSA300_1162 SAUSA300_1177 sun pknB recG fabD fabG smc topA gid xerC hslV hslU codY proS nusA infB cinA conserved hypothetical protein protein mraZ S-adenosyl-methyltransferase MraW cell division protein penicillin-binding protein 1 phospho-N-acetylmuramoyl-pentapeptidetransferase UDP-N-acetylmuramoylalanine--D-glutamate ligase cell division protein cell division protein ftsA cell division protein ftsZ conserved hypothetical protein phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase putative lipoprotein polypeptide deformylase methionyl-tRNA formyltransferase ribosomal RNA small subunit methyltransferase B conserved hypothetical protein protein phosphatase 2C domain protein protein kinase conserved hypothetical protein ATP-dependent DNA helicase RecG malonyl CoA-acyl carrier protein transacylase 3-oxoacyl-(acyl-carrier-protein) reductase chromosome segregation protein SMC DNA topoisomerase I glucose inhibited division protein tyrosine recombinase xerC ATP-dependent protease hslV heat shock protein HslVU ATPase subunit HslU GTP-sensing transcriptional pleiotropic repressor CodY prolyl-tRNA synthetase transcription termination factor NusA conserved hypothetical protein ribosomal protein L7Ae translation initiation factor IF-2 competence/damage-inducible protein cinA SAUSA300_1182 SAUSA300_1183 SAUSA300_1193 SAUSA300_1197 SAUSA300_1198 SAUSA300_1199 SAUSA300_1216 SAUSA300_1217 SAUSA300_1245 SAUSA300_1246 SAUSA300_1247 SAUSA300_1250 SAUSA300_1251 SAUSA300_1252 SAUSA300_1253 SAUSA300_1254 SAUSA300_1269 SAUSA300_1270 SAUSA300_1283 SAUSA300_1295 SAUSA300_1296 SAUSA300_1304 SAUSA300_1334 SAUSA300_1338 SAUSA300_1339 SAUSA300_1342 SAUSA300_1343 SAUSA300_1344 SAUSA300_1346 SAUSA300_1347 SAUSA300_1348 SAUSA300_1349 SAUSA300_1351 SAUSA300_1352 SAUSA300_1353 SAUSA300_1354 SAUSA300_1355 SAUSA300_1356 SAUSA300_1357 SAUSA300_1359 glpD opuD acnA parE parC glcT femA femB pstS nth birA birA aroA aroB aroC 1.47 1.47 1.56 1.28 1.28 1.50 1.40 2.32 1.36 1.27 1.29 1.42 1.55 1.29 1.52 1.48 1.33 1.35 0.0014 0.0015 0.0000 0.0339 0.0400 0.0002 0.0021 0.0407 0.0013 0.0199 0.0127 0.0032 0.0000 0.0171 0.0007 0.0001 0.0025 0.0019 2.15 1.46 2.47 1.28 4.54 1.33 1.39 1.33 1.66 1.63 0.0194 0.0085 0.0000 0.0166 0.0000 0.0049 0.0041 0.0126 0.0000 0.0000 1.37 1.60 1.73 1.65 1.54 1.46 1.42 1.50 1.48 1.49 1.60 1.38 0.0042 0.0000 0.0000 0.0001 0.0000 0.0001 0.0154 0.0000 0.0001 0.0007 0.0001 0.0140 pyruvate ferredoxin oxidoreductase alpha subunit pyruvate ferredoxin oxidoreductase beta subunit glycerol-3-phosphate dehydrogenase glutathione peroxidase putative GTP-binding protein putative aluminium resistance protein cardiolipin synthetase ABC transporter ATP-binding protein glycine betaine transporter opuD aconitate hydratase conserved hypothetical protein DNA topoisomerase IV subunit B DNA topoisomerase IV subunit A amino acid carrier protein transcription antiterminator putative membrane protein methicillin resistance protein FemA methicillin resistance protein FemB phosphate ABC transporter phosphate-binding protein PstS cold shock protein CSD family conserved hypothetical protein conserved hypothetical protein putative membrane protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein endonuclease III putative DNA replication protein DnaD putative DnaQ family exonuclease/DinG family helicase BirA bifunctional protein polyA polymerase glycosyl transferase group 1 family protein conserved hypothetical protein putative membrane protein conserved hypothetical protein conserved hypothetical protein 3-phosphoshikimate 1-carboxyvinyltransferase 3-dehydroquinate synthase chorismate synthase polyprenyl synthetase SAUSA300_1360 ubiE 1.38 0.0134 SAUSA300_1363 SAUSA300_1364 SAUSA300_1365 SAUSA300_1369 gpsA engA rpsA 1.44 1.44 1.33 2.26 0.0015 0.0240 0.0051 0.0000 1.33 1.49 2.25 1.35 1.44 1.28 1.28 1.35 0.0364 0.0248 0.0002 0.0002 0.0064 0.0172 0.0228 0.0302 1.47 2.22 2.02 2.01 0.0000 0.0000 0.0000 0.0000 SAUSA300_1464 1.46 0.0000 SAUSA300_1465 1.46 0.0000 SAUSA300_1466 1.48 0.0000 1.51 1.78 1.83 1.31 1.49 1.39 1.41 1.39 1.51 1.71 1.33 1.44 0.0000 0.0000 0.0000 0.0281 0.0427 0.0026 0.0032 0.0247 0.0000 0.0000 0.0239 0.0002 1.70 1.78 1.76 0.0000 0.0000 0.0000 SAUSA300_1393 SAUSA300_1410 SAUSA300_1440 SAUSA300_1442 SAUSA300_1449 SAUSA300_1450 SAUSA300_1454 SAUSA300_1456 SAUSA300_1459 SAUSA300_1460 SAUSA300_1462 SAUSA300_1463 srrA zwf gnd SAUSA300_1467 SAUSA300_1468 SAUSA300_1469 SAUSA300_1475 SAUSA300_1480 SAUSA300_1510 SAUSA300_1515 SAUSA300_1517 SAUSA300_1523 SAUSA300_1524 SAUSA300_1529 SAUSA300_1530 lpdA recN argR accC SAUSA300_1531 SAUSA300_1538 SAUSA300_1539 phoH prmA dnaJ fur dgkA menaquinone biosynthesis methyltransferase ubiE glycerol-3-phosphate dehydrogenase NADdependent GTP-binding protein EngA 30S ribosomal protein S1 pyridine nucleotide-disulfide oxidoreductase phiSLT ORF2067-like protein phage tail tape measure protein virulence-associated protein E conserved hypothetical protein staphylococcal respiratory response protein SrrA MutT/nudix family protein oxidoreductase aldo/keto reductase family glucose-6-phosphate 1-dehydrogenase alpha glucosidase 6-phosphogluconate dehydrogenase decarboxylating peptidase M20/M25/M40 family conserved hypothetical protein conserved hypothetical protein 2-oxoisovalerate dehydrogenase E2 component dihydrolipoamide acetyltransferase 2-oxoisovalerate dehydrogenase E1 component beta subunit 2-oxoisovalerate dehydrogenase E1 component alpha subunit 2-oxoisovalerate dehydrogenase E3 component lipoamide dehydrogenase DNA repair protein RecN arginine repressor acetyl-CoA carboxylase biotin carboxylase putative traG membrane protein 5-formyltetrahydrofolate cyclo-ligase subfamily ABC transporter permease protein endonuclease IV conserved hypothetical protein CBS domain pair protein diacylglycerol kinase conserved hypothetical protein phosphate starvation-induced protein PhoH family ribosomal protein L11 methyltransferase chaperone protein DnaJ SAUSA300_1540 SAUSA300_1541 SAUSA300_1542 SAUSA300_1561 SAUSA300_1562 SAUSA300_1563 dnaK grpE hrcA SAUSA300_1564 SAUSA300_1565 SAUSA300_1566 SAUSA300_1575 SAUSA300_1580 SAUSA300_1586 SAUSA300_1587 SAUSA300_1598 SAUSA300_1599 SAUSA300_1600 SAUSA300_1610 SAUSA300_1611 SAUSA300_1612 SAUSA300_1614 SAUSA300_1615 SAUSA300_1616 SAUSA300_1617 SAUSA300_1618 SAUSA300_1619 SAUSA300_1620 accB accC alaS aspS hisS ruvA folC valS tag hemL hemB hemD hemC hemX hemA clpX 1.54 1.41 1.36 2.29 2.15 1.94 0.0000 0.0031 0.0177 0.0000 0.0000 0.0000 2.16 2.22 1.69 1.60 2.44 1.26 1.31 1.28 1.44 1.29 1.29 1.38 1.42 1.81 1.81 2.00 1.65 1.77 1.77 1.54 0.0000 0.0000 0.0001 0.0000 0.0000 0.0437 0.0440 0.0094 0.0001 0.0119 0.0067 0.0007 0.0035 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0022 0.0000 0.0034 0.0375 0.0001 0.0342 0.0053 0.0000 0.0000 0.0001 0.0239 0.0013 0.0000 0.0001 SAUSA300_1621 SAUSA300_1623 SAUSA300_1624 SAUSA300_1629 SAUSA300_1632 SAUSA300_1634 SAUSA300_1635 SAUSA300_1636 coaE mutM polA 1.61 1.40 1.37 1.58 1.26 1.33 1.44 1.65 SAUSA300_1639 SAUSA300_1641 SAUSA300_1644 SAUSA300_1645 SAUSA300_1646 phoP gltA pyk pfkA accA 1.44 1.31 1.38 1.63 1.54 thrS chaperone protein DnaK co-chaperone GrpE heat-inducible transcription repressor HrcA putative membrane protein LamB/YcsF family protein acetyl-CoA carboxylase biotin carboxylase acetyl-CoA carboxylase biotin carboxyl carrier protein putative urea amidolyase conserved hypothetical protein alanyl-tRNA synthetase bacterial luciferase family protein aspartyl-tRNA synthetase histidyl-tRNA synthetase holliday junction DNA helicase RuvA ACT domain protein PheB GTP-binding protein Obg/CgtA folylpolyglutamate synthase valyl-tRNA synthetase DNA-3-methyladenine glycosidase glutamate-1-semialdehyde-21-aminomutase delta-aminolevulinic acid dehydratase uroporphyrinogen-III synthase porphobilinogen deaminase hemA concentration negative effector hemX glutamyl-tRNA reductase probable GTP-binding protein engB ATP-dependent Clp protease ATP-binding subunit ClpX conserved hypothetical protein MutT/nudix family protein threonyl-tRNA synthetase conserved hypothetical protein dephospho-CoA kinase formamidopyrimidine-DNA glycosylase DNA polymerase I superfamily alkaline phosphatase synthesis transcriptional regulatory protein PhoP citrate synthase II pyruvate kinase 6-phosphofructokinase acetyl-CoA carboxylase carboxyl transferase SAUSA300_1647 SAUSA300_1648 SAUSA300_1653 SAUSA300_1658 SAUSA300_1659 SAUSA300_1668 SAUSA300_1669 SAUSA300_1676 SAUSA300_1678 SAUSA300_1679 SAUSA300_1680 SAUSA300_1682 SAUSA300_1684 SAUSA300_1686 SAUSA300_1687 SAUSA300_1688 SAUSA300_1690 SAUSA300_1691 SAUSA300_1700 SAUSA300_1704 SAUSA300_1716 SAUSA300_1728 SAUSA300_1736 SAUSA300_1760 SAUSA300_1761 SAUSA300_1762 SAUSA300_1763 SAUSA300_1766 SAUSA300_1781 SAUSA300_1791 SAUSA300_1792 SAUSA300_1793 SAUSA300_1801 SAUSA300_1845 SAUSA300_1847 SAUSA300_1862 SAUSA300_1864 SAUSA300_1872 SAUSA300_1873 accD tpx sgtA fhs acsA acuA ccpA murC leuS epiG epiE epiF epiP epiB hemG cbf1 cbf1 fumC hemL 1.49 1.44 1.42 1.90 1.48 1.48 1.44 1.40 1.38 2.98 1.52 1.43 1.39 1.60 1.50 1.43 1.35 1.59 1.34 1.33 1.56 1.70 1.32 2.60 2.72 2.39 0.0022 0.0050 0.0070 0.0000 0.0000 0.0132 0.0031 0.0143 0.0006 0.0000 0.0027 0.0000 0.0101 0.0000 0.0000 0.0007 0.0115 0.0000 0.0018 0.0040 0.0121 0.0000 0.0385 0.0000 0.0000 0.0000 2.43 1.53 1.26 1.26 1.48 1.41 1.45 1.39 1.73 1.27 1.37 1.29 1.30 0.0000 0.0154 0.0133 0.0208 0.0000 0.0021 0.0002 0.0043 0.0000 0.0476 0.0165 0.0416 0.0413 alpha subunit acetyl-CoA carboxylase carboxyl transferase beta subunit putative NADP-dependent malic enzyme conserved hypothetical protein conserved hypothetical protein thiol peroxidase OsmC/Ohr family protein aminotransferase class V probable transglycosylase formate-tetrahydrofolate ligase acetyl-coenzyme A synthetase acetoin utilization protein AcuA catabolite control protein A conserved hypothetical protein UDP-N-acetylmuramate--alanine ligase FtsK/SpoIIIE family protein phenylalanyl-tRNA synthetase (beta subunit) putative thioredoxin glutamyl-aminopeptidase polysaccharide biosynthesis protein leucyl-tRNA synthetase conserved hypothetical protein oxidoreductase aldo/keto reductase family conserved hypothetical protein lantibiotic epidermin immunity protein F lantibiotic epidermin immunity protein F lantibiotic epidermin immunity protein F lantibiotic epidermin leader peptide processing serine protease EpiP lantibiotic epidermin biosynthesis protein EpiB protoporphyrinogen oxidase cmp-binding-factor 1 conserved hypothetical protein conserved hypothetical protein fumarate hydratase class II glutamate-1-semialdehyde-21-aminomutase conserved hypothetical protein conserved hypothetical protein putative membrane protein conserved hypothetical protein Mur ligase family protein SAUSA300_1874 SAUSA300_1876 SAUSA300_1880 SAUSA300_1884 SAUSA300_1885 SAUSA300_1886 SAUSA300_1887 SAUSA300_1892 SAUSA300_1893 SAUSA300_1894 SAUSA300_1895 SAUSA300_1896 SAUSA300_1909 SAUSA300_1922 SAUSA300_1976 SAUSA300_1983 SAUSA300_1986 SAUSA300_1995 SAUSA300_1996 SAUSA300_2006 SAUSA300_2007 SAUSA300_2008 SAUSA300_2009 SAUSA300_2010 SAUSA300_2024 SAUSA300_2027 SAUSA300_2028 SAUSA300_2029 SAUSA300_2030 SAUSA300_2042 SAUSA300_2046 SAUSA300_2053 SAUSA300_2064 SAUSA300_2076 SAUSA300_2079 SAUSA300_2081 SAUSA300_2086 SAUSA300_2087 SAUSA300_2093 SAUSA300_2097 gatB ligA pcrA pcrB nadE nadE pheA sak groES scrR amt ilvD ilvB ilvN ilvC leuA rsbV alr acpS oxaA atpB fba pyrG 2.03 1.46 0.0000 0.0023 1.27 1.33 1.46 1.48 0.0150 0.0059 0.0003 0.0001 1.40 1.29 1.32 1.29 1.59 1.50 1.50 1.38 1.49 1.32 1.42 1.30 2.74 1.66 1.50 2.02 1.47 1.37 1.26 1.44 1.38 1.40 1.46 1.55 1.25 1.28 1.29 1.35 1.30 2.01 1.72 1.92 1.67 2.05 0.0212 0.0364 0.0095 0.0278 0.0009 0.0302 0.0000 0.0118 0.0019 0.0140 0.0091 0.0254 0.0000 0.0003 0.0050 0.0000 0.0107 0.0468 0.0241 0.0001 0.0041 0.0032 0.0000 0.0018 0.0224 0.0379 0.0264 0.0437 0.0180 0.0000 0.0000 0.0000 0.0004 0.0000 ferritins family protein DNA polymerase IV Aspartyl/glutamyl-tRNA amidotransferase subunit B CamS sex pheromone cAM373 precursor DNA ligase ATP-dependent DNA helicase PcrA geranylgeranylglyceryl phosphate synthase family protein PcrB conserved hypothetical protein NH(3)-dependent NAD+ synthetase nicotinate phosphoribosyltransferase nitric oxide synthase oxygenase prephenate dehydratase conserved hypothetical protein staphylokinase precursor probable succinyl-diaminopimelate desuccinylase 10 kDa chaperonin nitroreductase family protein sucrose operon repressor ammonium transporter dihydroxy-acid dehydratase acetolactate synthase large subunit acetolactate synthase small subunit ketol-acid reductoisomerase 2-isopropylmalate synthase anti-sigma-B factor antagonist alanine racemase holo-(acyl-carrier-protein) synthase conserved hypothetical protein putative membrane protein conserved hypothetical protein membrane protein oxaA precursor conserved hypothetical protein ATP synthase F0 A subunit aldehyde dehydrogenase family protein fructose bisphosphate aldolase CTP synthase conserved hypothetical protein putative peptidase conserved hypothetical protein conserved hypothetical protein SAUSA300_2098 SAUSA300_2099 SAUSA300_2103 arsR 8.14 6.50 1.62 0.0000 0.0000 0.0001 SAUSA300_2104 SAUSA300_2105 SAUSA300_2125 SAUSA300_2138 SAUSA300_2142 SAUSA300_2143 SAUSA300_2144 SAUSA300_2145 SAUSA300_2147 SAUSA300_2148 SAUSA300_2150 SAUSA300_2151 SAUSA300_2152 SAUSA300_2153 SAUSA300_2154 SAUSA300_2155 SAUSA300_2163 SAUSA300_2164 SAUSA300_2166 SAUSA300_2179 SAUSA300_2180 SAUSA300_2182 SAUSA300_2183 SAUSA300_2184 SAUSA300_2185 SAUSA300_2187 SAUSA300_2189 SAUSA300_2190 SAUSA300_2192 SAUSA300_2193 SAUSA300_2194 SAUSA300_2195 SAUSA300_2197 SAUSA300_2198 SAUSA300_2199 SAUSA300_2201 SAUSA300_2202 glmS mtlF 2.34 1.55 1.52 1.24 1.46 1.84 1.77 3.86 1.38 1.44 2.40 2.76 4.50 6.15 4.68 10.18 1.56 1.77 1.58 1.36 1.26 1.46 1.32 1.34 1.29 1.43 1.35 1.40 1.44 1.36 1.31 1.34 1.46 1.35 1.28 1.29 1.26 0.0000 0.0201 0.0000 0.0247 0.0031 0.0000 0.0000 0.0000 0.0042 0.0013 0.0004 0.0080 0.0000 0.0000 0.0002 0.0000 0.0007 0.0003 0.0095 0.0030 0.0137 0.0004 0.0103 0.0037 0.0255 0.0013 0.0075 0.0003 0.0014 0.0036 0.0164 0.0102 0.0003 0.0012 0.0133 0.0130 0.0454 asp23 lacE lacF lacD lacC lacB lacA alsS rpsK rpsM infA adk rplO rpsE rplF rpsH rplE rplX rplN rpsQ rplP rpsC rplV rplB rplW transcriptional repressor ArsR family cation efflux family protein ABC transporter ATP-binding protein glucosamine--fructose-6-phosphate aminotransferase PTS system mannitol specific IIBC component ATP-binding protein Mrp/Nbp35 family conserved hypothetical protein alkaline shock protein 23 conserved hypothetical protein conserved hypothetical protein glycine betaine transporter alcohol dehydrogenase zinc-containing conserved hypothetical protein PTS system lactose-specific IIBC component PTS system lactose-specific IIA component tagatose 16-diphosphate aldolase tagatose-6-phosphate kinase galactose-6-phosphate isomerase galactose-6-phosphate isomerase conserved hypothetical protein conserved hypothetical protein alpha-acetolactate synthase 30S ribosomal protein S11 30S ribosomal protein S13 translation initiation factor IF-1 adenylate kinase preprotein translocase SecY subunit 50S ribosomal protein L15 30S ribosomal protein S5 50S ribosomal protein L6 30S ribosomal protein S8 50S ribosomal protein L5 50S ribosomal protein L24 50S ribosomal protein L14 30S ribosomal protein S17 50S ribosomal protein L16 30S ribosomal protein S3 50S ribosomal protein L22 50S ribosomal protein L2 50S ribosomal protein L23 SAUSA300_2203 rplD 1.31 0.0041 SAUSA300_2220 SAUSA300_2224 SAUSA300_2227 mobA moeA moeB 1.30 1.30 1.34 0.0402 0.0257 0.0123 SAUSA300_2230 SAUSA300_2257 SAUSA300_2258 SAUSA300_2261 SAUSA300_2267 SAUSA300_2268 SAUSA300_2274 modA 1.28 1.65 1.71 1.30 1.37 1.94 1.45 0.0214 0.0001 0.0000 0.0180 0.0169 0.0000 0.0112 1.37 1.48 1.91 1.36 2.17 1.51 1.71 1.38 1.51 1.30 1.48 1.50 1.50 1.25 1.42 2.90 1.29 4.68 4.66 4.70 2.34 2.90 3.02 2.91 1.57 1.55 1.45 1.45 0.0215 0.0446 0.0000 0.0218 0.0004 0.0444 0.0380 0.0230 0.0007 0.0148 0.0001 0.0010 0.0017 0.0173 0.0419 0.0339 0.0406 0.0036 0.0077 0.0039 0.0420 0.0180 0.0120 0.0000 0.0092 0.0007 0.0386 0.0009 SAUSA300_2275 SAUSA300_2277 SAUSA300_2278 SAUSA300_2281 SAUSA300_2288 SAUSA300_2306 SAUSA300_2307 SAUSA300_2308 SAUSA300_2309 SAUSA300_2312 SAUSA300_2315 SAUSA300_2317 SAUSA300_2319 SAUSA300_2329 SAUSA300_2330 SAUSA300_2333 SAUSA300_2340 SAUSA300_2341 SAUSA300_2342 SAUSA300_2343 SAUSA300_2344 SAUSA300_2345 SAUSA300_2346 SAUSA300_2347 SAUSA300_2350 SAUSA300_2381 SAUSA300_2383 SAUSA300_2389 hutI hutU hutG mqo gltT narK narI narJ narH nirD nirB nirR 50S ribosomal protein L4 molybdopterin-guanine dinucleotide biosynthesis protein A molybdopterin biosynthesis protein A molybdopterin biosynthesis protein B molybdenum ABC transporter molybdenumbinding protein ModA conserved hypothetical protein formate dehydrogenase alpha subunit conserved hypothetical protein hydrolase haloacid dehalogenase-like family sodium/bile acid symporter family protein putative membrane protein oxidoreductase short chain dehydrogenase/reductase family imidazolonepropionase urocanate hydratase formimidoylglutamase ABC transporter ATP-binding protein ABC transporter ATP-binding protein ABC transporter permease protein response regulator protein sensor histidine kinase malate:quinone-oxidoreductase putative lipoprotein putative zinc-binding dehydrogenase pyridine nucleotide-disulfide oxidoreductase proton/sodium-glutamate symport protein conserved hypothetical protein nitrite extrusion protein respiratory nitrate reductase gamma subunit respiratory nitrate reductase delta subunit respiratory nitrate reductase beta subunit respiratory nitrate reductase alpha subunit uroporphyrin-III C-methyl transferase nitrite reductase [NAD(P)H] small subunit nitrite reductase [NAD(P)H] large subunit nitrite reductase transcriptional regulator NirR conserved hypothetical protein conserved hypothetical protein amino acid permease putative drug transporter SAUSA300_2390 opuCd SAUSA300_2391 opuCc SAUSA300_2392 opuCb 2.26 2.27 2.69 0.0000 0.0000 0.0000 SAUSA300_2393 opuCa SAUSA300_2395 SAUSA300_2399 SAUSA300_2415 SAUSA300_2416 SAUSA300_2417 2.78 2.85 1.48 1.53 1.56 1.29 0.0000 0.0000 0.0074 0.0101 0.0003 0.0291 SAUSA300_2422 1.59 0.0004 SAUSA300_2433 SAUSA300_2447 SAUSA300_2451 SAUSA300_2452 SAUSA300_2457 SAUSA300_2458 SAUSA300_2462 SAUSA300_2463 SAUSA300_2468 SAUSA300_2475 1.30 1.50 1.93 2.72 5.13 5.44 1.89 2.01 1.59 1.57 0.0211 0.0180 0.0001 0.0004 0.0000 0.0000 0.0000 0.0000 0.0149 0.0004 1.65 1.36 0.0037 0.0262 1.80 2.98 1.53 2.12 1.59 1.82 1.92 2.17 2.51 2.61 2.30 1.85 1.83 1.61 0.0000 0.0000 0.0278 0.0450 0.0041 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0010 0.0037 SAUSA300_2476 SAUSA300_2478 SAUSA300_2485 SAUSA300_2486 SAUSA300_2487 SAUSA300_2488 SAUSA300_2492 SAUSA300_2494 SAUSA300_2495 SAUSA300_2498 SAUSA300_2499 SAUSA300_2500 SAUSA300_2501 SAUSA300_2502 SAUSA300_2510 SAUSA300_2511 frp ddh ptsG cidB feoB feoA crtN crtM glycine betaine/carnitine/choline transport system permease glycine betaine/carnitine/choline ABC transporter glycine betaine/carnitine/choline ABC transporter glycine betaine/carnitine/choline ABC transporter ATP-binding protein amino acid permease ABC transporter ATP-binding protein conserved hypothetical protein glucose 1-dehydrogenase-like protein putative transporter oxidoreductase short-chain dehydrogenase/reductase family phosphoglucomutase/phosphomannomutase family protein conserved hypothetical protein drug transporter transcriptional regulator MarR family phospholipase/carboxylesterase family protein glyoxylase family protein NAD(P)H-flavin oxidoreductase D-lactate dehydrogenase acetyltransferase GNAT family conserved hypothetical protein phosphotransferase system glucose-specific IIABC component Holin-like protein cidB methylated DNA-protein cysteine methyltransferase putative ATP-dependent Clp proteinase ferrous iron transport protein B ferrous iron transport protein A acetyltransferase family protein copper-translocating P-type ATPase copper chaperone copZ squalene synthase squalene desaturase glycosyl transferase phytoene dehydrogenase conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein SAUSA300_2525 SAUSA300_2526 SAUSA300_2529 SAUSA300_2538 SAUSA300_2539 SAUSA300_2545 SAUSA300_2546 SAUSA300_2547 SAUSA300_2549 SAUSA300_2558 SAUSA300_2573 SAUSA300_2581 SAUSA300_2582 SAUSA300_2583 SAUSA300_2584 SAUSA300_2592 SAUSA300_2603 SAUSA300_2620 SAUSA300_2622 SAUSA300_2626 SAUSA300_2632 SAUSA300_2642 SAUSA300_2644 SAUSA300_2645 pyrD betA betB bccT isaB lip gidB gidA 1.83 1.28 1.72 1.65 2.00 2.90 2.68 1.63 0.0000 0.0400 0.0000 0.0031 0.0000 0.0000 0.0000 0.0000 1.91 1.41 3.60 2.33 1.40 1.42 1.34 1.48 1.71 1.68 1.34 2.14 1.58 1.92 1.31 1.27 0.0000 0.0049 0.0000 0.0000 0.0012 0.0004 0.0104 0.0355 0.0032 0.0019 0.0191 0.0000 0.0022 0.0005 0.0173 0.0083 conserved hypothetical protein dihydroorotate dehydrogenase conserved hypothetical protein amino acid permease family protein aminotransferase choline dehydrogenase glycine betaine aldehyde dehydrogenase conserved hypothetical protein choline/carnitine/betaine transporter BCCT family sensor histidine kinase immunodominant antigen B putative surface anchored protein conserved hypothetical protein putative glycosyl transferase preprotein translocase secA protein conserved hypothetical protein triacylglycerol lipase precursor conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein putative membrane protein conserved hypothetical protein glucose-inhibited division protein B glucose-inhibited division protein A
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