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aprepitant / fosaprepitant
Medication Information Sheet
aprepitant / fosaprepitant (ah­PREH­pih­tant / fos­ah­PREH­pih­
tant) This document provides general information about your medication. It does not replace the advice of your health care professional. Always discuss your therapy with your health care professional and refer to the package insert for more details.
Other name: Emend®, Emend® IV
Appearance: Aprepitant­ Capsules (days 1 to 3) in various strengths Fosaprepitant­ Clear, colourless solution for injection (day 1 only) What it is used for
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Used with other medications for preventing nausea and vomiting that may be caused by your chemotherapy treatment. Before receiving it
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Tell your doctor and pharmacist if you have/had significant medical condition(s), especially if you have / had liver problems or any allergies.
You will receive other prescriptions for anti­nausea to be used before and/or after chemotherapy. Ensure you fill these prescriptions before you start your treatment. Follow your doctor and pharmacist's instructions carefully.
Pregnancy and breastfeeding
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Aprepitant is not recommended for use during pregnancy. Let your doctor know if you are pregnant or plan to become pregnant.
Aprepitant may reduce the effectiveness of birth control pills; therefore, alternative or back­up methods of birth control should be used during aprepitant treatment and for one month after the last dose of aprepitant. Discuss with your healthcare team.
Tell your doctor right away if you or your partner becomes pregnant.
Do not breastfeed while taking this drug.
Effects on Fertility: No
How it is given
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Take aprepitant as directed by your doctor. On day 1, the 125mg dose of aprepitant should be taken by mouth one hour before your chemotherapy treatment. The 80 mg dose should be taken by mouth each morning on days 2 and 3 of your chemotherapy cycle.
Aprepitant may be taken with or without food.
*The most updated version and more symptom control information can be found on: http://www.cancercare.on.ca/druginfo Prepared with input from the Cancer Care Ontario-Medication Information Sheets Working Group.
April 2014
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Swallow capsule whole with a glass of water.
Alternatively, your doctor may order fosaprepitant to be given by injection through your vein on day 1 only.
Aprepitant / fosaprepitant must be used with other anti­nausea drugs specified by your doctor. Make sure you understand and follow the instructions carefully, in order to receive the most benefit from these medications.
While receiving it
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Do not have any grapefruit, starfruit, Seville oranges or their juices/products while on this treatment, since this may increase side effects.
This drug often interacts with other drugs, and can result in the drugs not working as well or cause severe side effects.
Make sure your doctor and pharmacist know about all your medicines (prescription, over­the­
counter, herbals and supplements). Check with your doctor or pharmacist before starting or stopping any of them. Safety / Storage
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Do not throw out any unused drugs at home. Bring them to your pharmacy for safe disposal.
Aprepitant: Store in the original packaging at room temperature, away from heat, light or moisture. Keep out of reach of children and pets.
Side effects and what to do
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The following side effects have been seen in people using aprepitant / fosaprepitant with other chemotherapy drugs, so some of these effects may also be related to chemotherapy.
The following side effects are common or severe. You may not have all of the side effects listed, while others not on this list may also occur. Discuss with your doctor if you have any unusual or bothersome symptoms.
Side effects and what to do
When to contact doctor?
Most Common Side Effects
Poor Appetite; don't feel like eating; weight loss
l Eat foods that you like and try to eat regular small meals. l Use meal supplements if possible. See a dietitian. Contact doctor if no improvement or if severe
Constipation
l Eat a balanced diet with fibres such whole grains, fruit and raw vegetables. l Drink plenty of fluids. Try light exercise regularly. l Speak to your doctor if no bowel movement for 3 or more days. l Also see Constipation Pamphlet.* Contact doctor if no improvement or if severe
Hiccups l Drink clear fluids and avoid large meals. Contact doctor if no improvement or if severe
*The most updated version and more symptom control information can be found on: http://www.cancercare.on.ca/druginfo Prepared with input from the Cancer Care Ontario-Medication Information Sheets Working Group.
April 2014
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Diarrhea l May occur days to weeks after the drug is given / after treatment starts. l Drink plenty of clear fluids. Limit hot, spicy, fried foods, foods/drinks with caffeine, orange or prune juice. Try a low­fiber BRAT diet (Bananas, white Rice, Apple sauce, Toast made with white bread). l Take anti­diarrhea drug(s) if given to you by your doctor. l Also see Diarrhea pamphlet.* Contact doctor if no improvement or if severe
Tiredness l Rest often; take naps if needed. Move slowly when getting up. l Eat well­balanced meals and drink plenty of fluids. Light exercise may help. l Do not drive a motor vehicle or operate machinery when feeling tired. Contact doctor if no improvement or if severe
Less Common Side Effects, but may be Severe
Reactions at the injection site (redness, itchiness, bruising, mild rash or swelling, with fosaprepitant use)
• Let your health care team know right away when this happens, since this drug may irritate tissues if it leaks from the vein during injection.
Heart problems (irregular heartbeat, chest pain, fainting, swelling in legs/ankles/belly, shortness of breath)
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Get emergency medical help right away
Blockage of an artery (blood vessel) in your heart, brain, chest, belly, or limbs; this Get emergency may result in stroke (sudden loss of vision, speech, or the use of your limb(s)) or medical help right heart attack (chest pain, shortness of breath), or pain in chest, belly or limb
away
Rupture in stomach or intestine wall (Sudden, severe pain in belly or stomach area)
Get emergency medical help right away
Allergic reaction (fever, severe rash, itchiness, swollen face, lip or tongue, chest or Get emergency medical help right throat tightness; may occur during or shortly after the drug is given)
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Kidney problems (lower back pain, body swelling, passing little or no urine, or recent unusual weight gain)
Get emergency medical help right away
Lung problems
(increased cough, breathing problems, chest pain, coughing blood)
Get emergency medical help right away
Rash; dry, itchy skin l Stay out of the sun; wear sunblock, a hat and cover exposed skin. l Use daily moisturizer. l Severe rash may occur on the body/limbs with blistering or peeling of skin: Get emergency medical help right away if this occurs. Contact doctor if no improvement or if severe
Blood clot (limb pain or swelling, hardened vein in limb), may occur in lungs (sudden Get emergency start of coughing, breathing problems, chest pain, coughing blood)
medical help right away
*The most updated version and more symptom control information can be found on: http://www.cancercare.on.ca/druginfo Prepared with input from the Cancer Care Ontario-Medication Information Sheets Working Group.
April 2014
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The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition. A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.
*The most updated version and more symptom control information can be found on: http://www.cancercare.on.ca/druginfo Prepared with input from the Cancer Care Ontario-Medication Information Sheets Working Group.
April 2014
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