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DRAFT FOR STAT 4.1.05 NEW “MIND OVER MIGRAINE” EDUCATIONAL CAMPAIGN HELPS PEOPLE WITH MIGRAINE GET ON TRACK TO BETTER HEALTH SUGGESTED ANCHOR LEAD: FOR THE 28 MILLION AMERICANS WHO EXPERIENCE MIGRAINE, APPLYING A COMPREHENSIVE APPROACH TO MIGRAINE MANAGEMENT MAY ADD UP TO MORE MIGRAINE-FREE DAYS. A RECENT SURVEY AMONG PEOPLE WHO EXPERIENCED “VERY” OR “EXTREMELY” SEVERE MIGRAINE CONDUCTED BY HARRIS INTERACTIVE® ON BEHALF OF THE AMERICAN COUNCIL FOR HEADACHE EDUCATION (ACHE) AND ORTHO-MCNEIL NEUROLOGICS, INC. FOUND PEOPLE WITH MIGRAINE LOSE NEARLY SIX DAYS OVER A THREE-MONTH PERIOD AS A RESULT OF MIGRAINE. THROUGH “MIND OVER MIGRAINE,” A NEW EDUCATIONAL INITIATIVE SPONSORED BY ORTHO-MCNEIL NEUROLOGICS, INC., PEOPLE CAN ACCESS INFORMATION TO HELP THEM BETTER UNDERSTAND MIGRAINE, TREATMENT OPTIONS, AND LIFESTYLE MODIFICATIONS THAT MAY MAKE THE CONDITION MORE MANAGEABLE. RENI MITCHELL HAS MORE. VIDEO AUDIO Shannon in kitchen FOR YEARS, SHANNON LENIHAN ATTEMPTED TO MANAGE HER MIGRAINE ATTACKS THROUGH VARIOUS TREATMENTS AND APPROACHES. FINALLY SHE FOUND THE RIGHT COMBINATION TO EXPERIENCE FEWER MIGRAINE ATTACKS. Soundbite Shannon Lenihan Migraine patient “I first began experiencing migraines about when I was five years old, that point I could begin to tell my mom that my head hurt and that I was in a lot of pain. My mom was able to help because she had migraines and she was able to recognize the symptoms, and from there they got worse and more frequent.” NOW A NEW EDUCATIONAL PROGRAM MAY BRING HELP TO PEOPLE WHO SUFFER 1 National Headache Foundation pg. 2 Harris Interactive Survey Slide 7 DRAFT FOR STAT 4.1.05 “Mind Over Migraine” logo Doctor/patient footage FROM THIS CHRONIC AND DEBILITATING CONDITION. “MIND OVER MIGRAINE,” SPONSORED BY ORTHO-MCNEIL NEUROLOGICS, INC. IS DESIGNED TO HELP PEOPLE WITH MIGRAINE REACH THEIR GOALS OF LEADING A HEALTHY LIFESTYLE, INCLUDING A LIFE WITH FEWER MIGRAINE ATTACKS. RESEARCH SUGGESTS THAT MIGRAINE MAY BE A PROGRESSIVE DISEASE THAT CAN BECOME WORSE OVER TIME; FOR PEOPLE WHO EXPERIENCE FREQUENT OR SEVERE MIGRAINE ATTACKS – 2 OR MORE MIGRAINE ATTACKS A MONTH - IT IS IMPORTANT TO FIND AN APPROPRIATE TREATMENT PLAN THAT MAY INVOLVE PREVENTING ATTACKS IN THE FIRST PLACE SO THEY CAN GET FEWER OF THEM. Soundbite Elizabeth Loder, M.D. Assistant Professor of Medicine Harvard Medical School Director, Pain and Headache Management Program Spaulding Rehabilitation Hospital Boston, MA “Probably the most important aspect of the program is that it encourages patients in speaking with their doctor about migraine and its impact on their lives, and we know that when the lines of communication between doctors and patients are open, treatment goes a lot better and people do better in the long run.” Shannon reading booklet “MIND OVER MIGRAINE” RESOURCES INCLUDE AN EDUCATIONAL BOOKLET AND A WEB SITE THAT OFFER PRACTICAL TOOLS DESIGNED TO EMPOWER PEOPLE WHO EXPERIENCE MIGRAINE TO HELP LIVE THEIR LIVES WITH FEWER MIGRAINE ATTACKS. Shannon at computer Soundbite Elizabeth Loder, M.D. Assistant Professor of Medicine Harvard Medical School Director, Pain and Headache Management Program Spaulding Rehabilitation Hospital Boston, MA “The ‘Mind Over Migraine’ program can really help patients who might feel frustrated by the fact that their current migraine treatment is not working especially well. Medications like TOPAMAX® (topiramate) combination with reasonable lifestyle changes and other interventions can go a long way toward helping patients cope more effectively.” 2 Kruit, Migraine as a Risk Factor p. 432 Goadsby (Drug Therapy), pg. 260 DRAFT FOR STAT 4.1.05 Doctor/patient footage TOPAMAX® (topiramate) Tablets manufacturing footage Chiron: The goals of migraine prevention are: Reduce the frequency and duration of attacks Improve responsiveness to medications you take at the onset of an attack Improve function and reduce IT’S IMPORTANT TO DISCUSS AVAILABLE MIGRAINE TREATMENTS WITH A PHYSICIAN. ACCORDING TO THE SURVEY SPONSORED BY THE AMERICAN COLLEGE FOR HEADACHE EDUCATION AND ORTHOMCNEIL NEUROLOGICS, NEARLY TWOTHIRDS OF SURVEY RESPONDENTS SAID THEY HAD NOT DISCUSSED MIGRAINE PREVENTION AS A TREATMENT OPTION WITH THEIR PHYSICIAN. FOR PATIENTS WHO EXPERIENCE FREQUENT MIGRAINE ATTACKS, MIGRAINE PREVENTION THERAPY SUCH AS TOPAMAX MAY BE AN EFFECTIVE WAY TO HELP MANAGE THIS CONDITION. TOPAMAX IS APPROVED FOR MIGRAINE PREVENTION IN ADULTS ONLY. THE USEFULNESS OF TOPAMAX IN THE ACUTE TREATMENT OF MIGRAINE HEADACHES HAS NOT BEEN STUDIED. disability “By working with my doctor, I was able to have him understand and listen to me, together we were able to set up a regimen of lifestyle changes along with taking TOPAMAX which greatly helped reduce the frequency of my migraine.” Chiron: TOPAMAX (topiramate) has TOPAMAX (TOPIRAMATE) HAS BEEN APPROVED FOR MIGRAINE PREVENTION IN MORE THAN 31 COUNTRIES WORLDWIDE. TOPAMAX IS INDICATED FOR THE PREVENTION OF MIGRAINE HEADACHES IN ADULTS ONLY. THE USEFULNESS OF TOPAMAX IN THE ACUTE TREATMENT OF MIGRAINE HEADACHES HAS NOT BEEN STUDIED. SERIOUS RISKS ASSOCIATED WITH TOPAMAX INCLUDE INCREASED EYE PRESSURE (GLAUCOMA), DECREASED prevention more than 31 countries worldwide. TOPAMAX is indicated for the prevention of migraine headaches in adults only. The usefulness of TOPAMAX in the acute treatment of migraine headaches has Harris Interactive Survey slide 16 Goadsby (Drug Therapy), pg. 260 TOPAMAX PI Soundbite Shannon Lenihan Migraine patient been approved for migraine Ramadan NM, Silberstein SD, et al. US Headache Consortium Evidencebased Guidelines. AAN. US Healache Consortium 2000:3. 3 Topamax PI DRAFT FOR STAT 4.1.05 not been studied. “Mind Over Migraine” Web site SWEATING, INCREASED BODY TEMPERATURE, KIDNEY STONES, SLEEPINESS, DIZZINESS, CONFUSION, AND DIFFICULTY CONCENTRATING. TELL YOUR DOCTOR IMMEDIATELY IF YOU HAVE BLURRED VISION OR EYE PAIN. MORE COMMON SIDE EFFECTS ARE TINGLING IN ARMS AND LEGS, LOSS OF APPETITE, NAUSEA, DIARRHEA, TASTE CHANGE AND WEIGHT LOSS. YOUR DOCTOR MAY DO SIMPLE BLOOD TESTS. TELL YOUR DOCTOR ABOUT OTHER MEDICATIONS YOU TAKE. IF YOU SUFFER FROM FREQUENT OR SEVERE MIGRAINES, TALK TO YOUR DOCTOR TO DETERMINE THE BEST TREATMENT FOR YOU. PLEASE SEE FULL U.S. PRESCRIBING INFORMATION AT WWW.TOPAMAX.COM OR CALL 1-800-682-6532 FOR MORE INFORMATION. FOR MORE INFORMATION ABOUT “MIND OVER MIGRAINE,” VISIT WWW.MINDOVERMIGRAINE.COM. THIS IS RENI MITCHELL. SUGGESTED ANCHOR TAG: FOR MORE INFORMATION ABOUT THE “MIND OVER MIGRAINE” PROGRAM, VISIT WWW.MINDOVERMIGRAINE.COM OR CALL 1-800-617-1144. Additional B-Roll/Soundbites: Additional B-Roll Dr. Loder/patient footage Shannon lifestyle footage Simulation footage Pharmacy footage Manufacturing shots Soundbites “It’s helpful for patients to be as clear as possible in speaking with their doctor about the impact that migraine is having on their lives. That’s useful to the doctor in Dr. Loder: 4 DRAFT FOR STAT 4.1.05 formulating a treatment plan that includes such strategies as TOPAMAX to help patients have more migraine-free days.” Dr. Loder: “When patients are clear with their doctors about impact that migraine is having on their lives, it’s very useful to the doctor in formulating a treatment plan, a treatment plan that for example might include TOPAMAX and other measures to decrease the number of headache attacks that someone has.” Dr. Loder: “I think a program like ‘Mind Over Migraine’ can really help the doctorpatient relationship, because it puts patients in the driver’s seat. Too often, people who have chronic illnesses like migraine feel as if they’re dependent on doctors or other healthcare professionals for advice and recommendations about everything they do. In fact, in chronic conditions most people who take an interest in managing their own condition do much better in the long run.” Dr. Loder: “’Mind Over Migraine’ provides patients with concrete suggestions and tips about how to cut down on the number of headaches they have through important lifestyle changes, and also helps them think about how to discuss the impact that migraine has on their lives with their doctors.” Shannon Lenihan: “In addition to taking TOPAMAX, I try to keep my life on a regular schedule by you know, eating regularly at the same times, getting enough sleep, just not add additional stressers to my life, try to keep those to a minimum.” 5 DRAFT FOR STAT 4.1.05 “Migraine is unlike any other headache. It starts right, for me, right at my left side only, goes right down my head, into my neck, into my shoulder. From there if the pain medication doesn’t work quick enough, I start to get nauseous, and I need to lie down until it goes away, just be in a quiet room.” Shannon Lenihan: 6