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Table S1: Changes in gene expression between wild type Lamin C and ΔN Gene symbol Gene name Fold change p value Function Electron carrier activity; heme binding; iron ion binding; oxidoreductase activity* Axon guidance DNA binding; sequencespecific DNA binding; transcription factor activity* Glutathione transferase activity Cyp4p2 Cyp4p2 144.4 7.53E-07 PlexB Plexin B 23.84 4.09E-08 Ets65A Ets at 65A 12.6 6.22E-08 GstD5 Glutathione S transferase D5 10.47 1.27E-04 CG9935 - 8.77 4.18E-06 CG34007 - 7.96 7.33E-05 CG1074 - 7.36 2.87E-07 CG31781 - 5.50 5.18E-06 4.91 9.40E-05 4.21 1.43E-04 Oxidoreductase activity* RNA binding; pseudouridine synthase activity; 1.74E-04 diaminohydroxyphosphori bosylaminopyrimidine deaminase activity* Lateral inhibition in cell 3.25E-05 fate determination Methyltransferase activity; 4.37E-06 nucleic acid binding* 9.57E-05 Unknown Nucleic acid binding; zinc ion binding* 4.82E-05 CG2064 Glutathione S transferase D9 - RluA-1 RluA-1 4.07 CG32021 - 3.39 CG14906 - 3.72 GstD9 CG33494 CG3630 CG3448 Activityregulated cytoskeleton associated protein 1 - alphaTub84 D alpha-Tubulin at 84D Arc1 3.60 2.89 2.54 2.41 2.39 Extracellular-glutamategated ion channel activity* Unknown Methyltransferase activity; nucleic acid binding* Lateral inhibition in cell fate determination Glutathione transferase activity 1.62E-05 Unknown 5.93E-05 DNA binding* GTP binding; GTPase binding; structural 7.62E-05 constituent of cytoskeleton*; Myosin binding CG33205 CG16787 Ribosomal protein S11 - Plum Plum -2.11 Sclp CG10365 Sclp - -2.49 -2.54 NnaD Nna1 ortholog -2.56 l(2)03659 lethal(2)0365 9 -5.08 gkt glaikit -6.31 RpS11 CG32850 - *Inferred from amino acid sequence 2.06 2.04 2.03 -6.98 1.46E-04 Mesoderm development Structural constituent of 2.74E-05 ribosome* 2.18E-05 Unknown Negative regulator of synaptic growth at the 2.01E-05 neuromuscular junction; neuron remodeling 7.23E-06 Muscle function 1.77E-04 Unknown Metallocarboxypeptidase activity; purine nucleotide binding; zinc binding*; 4.34E-05 larval and neural retina development; mitochondrion organization ATP binding; ATPase activity; couple to 1.47E-06 transmembrane movement of substances; transporter activity* 3’-tyrosyl-DNA phosphodiesterase activity*; central nervous 1.60E-07 system development; establishment and maintenance of epithelial cell apical/basil polarity Ubiquitin-protein 1.82E-05 transferase activity; zinc ion binding*