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Last Name, Name Eibel, Hermann born: October 6th 1954 Position Title Group leader University Medical Center Freiburg EDUCATION/TRAINING Institution and Location Degree University of Basel, Switzerland Diploma University of Basel, Switzerland Dr. .phil. nat. Year(s) 19741979 19791982 Field of Study Biology II Molecular Genetics A. Positions and Honors Employment/Experience 1983-1985 Postdoctoral Fellow, Inst. Bio III, Albert-Ludwigs University Freiburg 1985-1992 Group leader, MPI for Immunobiology, Freiburg 1992Head of Clinical Research Unit for Rheumatology, University Medical Center Freiburg, Honors, Awards, and Scholarships 1982 Fellowship of Deutsche Forschungsgemeinschaft Other Scientific Activities 1999-2003 Competence Network Rheumatology B. Selected Publications (10 most important 2006-2001) - Taubenheim N, von Hornung M, Durandy A, Warnatz K, Corcoran L, Peter HH, Eibel H. Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients. J Immunol. 2005;175:54985503. - Wieland GD, Nehmann N, Muller D, Eibel H, Siebenlist U, Suhnel J, Zipfel PF, Skerka C. Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65. J Cell Sci. 2005;118:3203-3212. - Wehr C, Eibel H, Masilamani M, Illges H, Schlesier M, Peter HH, Warnatz K. A new CD21low B cell population in the peripheral blood of patients with SLE. Clin Immunol. 2004;113:161-171. - Aicher WK, Alexander D, Haas C, Kuchen S, Pagenstecher A, Gay S, Peter HH, Eibel H. Transcription factor early growth response 1 activity upregulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts. Arthritis Rheum. 2003;48:348-359. - Decker EL, Nehmann N, Kampen E, Eibel H, Zipfel PF, Skerka C. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res. 2003;31:911-921. - Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Drager R, Eibel H, Fischer B, Schaffer AA, Mages HW, Kroczek RA, Peter HH. Homozygous - - - - loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol. 2003;4:261-268. Groth C, Drager R, Warnatz K, Wolff-Vorbeck G, Schmidt S, Eibel H, Schlesier M, Peter HH. Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID). Clin Exp Immunol. 2002;129:133-139. Warnatz K, Denz A, Drager R, Braun M, Groth C, Wolff-Vorbeck G, Eibel H, Schlesier M, Peter HH. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood. 2002;99:1544-1551. Denz A, Eibel H, Illges H, Kienzle G, Schlesier M, Peter HH. Impaired upregulation of CD86 in B cells of "type A" common variable immunodeficiency patients. Eur J Immunol. 2000;30:1069-1077. Aicher WK, Dinkel A, Grimbacher B, Haas C, Seydlitz-Kurzbach EV, Peter HH, Eibel H. Serum response elements activate and cAMP responsive elements inhibit expression of transcription factor Egr-1 in synovial fibroblasts of rheumatoid arthritis patients. Int Immunol. 1999;11:47-61. List of recent Diplomanden/Diplomandinnen: Gorka, Oliver: Hedgehog signalling in rheumatoid arthritis. Freiburg 2007. Stabenow, Ulrike. Hedgehog signalling in B cell development. Freiburg, 2007. Hamm, Stefanie, Plasma cell development in patients suffering from common variable immunodeficiency. Freiburg 2007.
