Download Current database

The EBMT Registry Database
MC Ruiz de Elvira
Revised: Feb 2015
The European Group for Blood and Marrow Transplantation
Relational database
The concept
parent table – one level
Patient
PatID
12
25
29
44
Diagnosis
PatID
12
25
29
Date Diag
24/05/1967
13/12/2001
04/06/1954
shared field (key index)
Treatment
PatID
25
25
44
Date Tran
04/12/2002
07/01/2003
25/07/1988
Study
PatID
12
29
29
44
Number
1
1
2
1
children
tables
one level
below
The European Group for Blood and Marrow Transplantation
Relational database
The concept
Level definition
• Series of tables which do not depend on each
other’s existence or content
• All depend on the existence and content of the
same parent table
• They all share at least one field (index) with the
parent table and, therefore, among each other.
The European Group for Blood and Marrow Transplantation
Data storage: example
Flat style
PatId
1
2
3
WBC* Diag
…
…
…
WBC Treat
null
…
null
WBC Mob
null
null
…
WBC Tran
…
…
…
WBC FUp
…
…
null
EBMT database
PatId
1
1
1
2
2
2
2
3
3
3
Date
02/02/1990
04/04/1991
10/10/1991
01/01/1980
03/03/1980
07/07/1987
12/12/1987
02/02/1992
04/04/1993
05/05/1993
Type
Diag
Tran
Fup
Diag
1st line
Tran
Fup
Diag
Mob
Tran
WBC
…
…
…
…
…
…
…
…
…
…
The European Group for Blood and Marrow Transplantation
EBMT Registry Database
Centre
Patient
Study
Drugs
(Chemo)
Diagnosis
Treatment
Stem cell
counts
Molecular
Treat Compl
Donor
Donor
assessment
Donation procedure
complications
Circulating AB
Level 1
Level 2
Assessment(1)
Cytogenetics
Infections
Dis Compl
EBMT
studies
Involvement
Level 3
Level 4
Questionnaire
Chimaerism
Level 5
Level 6
The European Group for Blood and Marrow Transplantation
EBMT database
Level 1
Centre
One entry per membership
[CIC]
Membership
Patient
As many entries as person members
[CIC] [PI] Unit Address City …
As many entries as patients
[CIC] [PatId] Date of birth …
level 2
The European Group for Blood and Marrow Transplantation
EBMT database
Level 2
Patient information
date of birth
initials
date of death
Administrative fields
Outcome summary
Patient
As many entries as patients
[CIC] [PatId] Date of birth …
dates of graft
status
date last seen
Diagnosis
level 3
As many entries as new diagnosis
[CIC] [PatId] [DoDiag] Diagnosis …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 3
Study
name of study
As many entries as studies
[CIC] [PatId] [Number] Study name…
The European Group for Blood and Marrow Transplantation
EBMT database
Level 3
Diagnosis
As many entries as new diagnosis
[CIC] [PatId] [DoDiag] Diagnosis …
date of diagnosis
disease classification: FAB, REAL, etc
stage
secondary origin
The European Group for Blood and Marrow Transplantation
EBMT database
Level 3
allo or auto
stem cell source
reason
response
modalities
Treatment
As many entries as new treatments
[CIC] [PatId] [DoTrt] SC MoAB Chemo …
Drugs (Chemo)
level 4
As many entries as drugs
[CIC] [PatId] [DoTrt] [Regimen] Dose Days …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
Treatment
As many entries as new treatments
[CIC] [PatId] [DoTrt] SC MoAB Chemo …
name of drug / protocol
dose
As many entries as drugs
units
[CIC] [PatId] [DoTrt] [Drug] Dose Days …
route of administration
date start that particular drug
date end that particular drug
Drugs (Chemo)
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
cell type
timing
number of cells
Treatment
As many entries as new treatments
[CIC] [PatId] [DoTrt] SC MoAB Chemo …
Stem cell counts
As many entries as cells measured
[CIC] [PatId] [DoTrt] [Source/Timing] Type …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
donor age
donor sex
donor registry
HLA match
cell infusion
donor HLA
cell manipulaton
Treatment
As many entries as new treatments
[CIC] [PatId] [DoTrt] SC MoAB Chemo …
Donor
As many entries as donors per treatment
[CIC] [PatId] [DoTrt] [DonId] Sex Match …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 5
level 4
history
medication
Donor
As many entries as donors per treatment
[CIC] [PatId] [DoTrt] [DonId] Sex Match …
Donor Assessment
As many entries as donor follow up
[CIC] [PatId] [DoTrt] [DonId] [DoDFUp] History…
The European Group for Blood and Marrow Transplantation
EBMT database
Level 6
Donor Assessment
As many entries as donor follow up
[CIC] [PatId] [DoTrt] [DonId] [DoDFUp] History…
Donor Procedure Complications
complication
As many entries as donor complications
date
[CIC] [PatId] [DoTrt] [DonId] [DoDFUp] [Complication]
Date…
The European Group for Blood and Marrow Transplantation
EBMT database
Level 3
date of assessment
haematological values
As many entries as new Assessment(1)
biochemical values
[CIC] [PatId] [DoAssess] Hg WBC …
disease involvement
immunophenotyping assessed
cytogenetics done
incidence of infections
incidence of complications
GvHD
patient HLA
Assessment(1)
Cytogenetics
level 4
As many entries as abnormalties studied
[CIC] [PatId] [DoAssess] [Abnormality] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
complication
presence
description
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Treat compl
As many entries as treatment complications studied
[CIC] [PatId] [DoAssess] [TComplic] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
abnormality
presence
description
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Cytogenetics
As many entries as abnormalties studied
[CIC] [PatId] [DoAssess] [Abnormality] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
infection episode
pathogen
description
isolation method
date started
date end
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Infections
As many entries as infections studied
[CIC] [PatId] [DoAssess] [Infection] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
site
primary
metastatic
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Involvement
As many entries as phenotypes studied
[CIC] [PatId] [DoAssess] [Site] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
marker
presence
description
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Molecular
As many entries as molecular markers studied
[CIC] [PatId] [DoAssess] [Marker] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
cell type
% chimaerims
technique
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Chimaerism
As many entries as molecular markers studied
[CIC] [PatId] [DoAssess] [DoTest] Cell type…
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Dis compl
complication
description
As many entries as disease complications studied
indication for transplant [CIC] [PatId] [DoAssess] [DComplic] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
antibody
level
titer
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Circulating AB
As many entries as molecular markers studied
[CIC] [PatId] [DoAssess] [Antibody] Presence …
The European Group for Blood and Marrow Transplantation
EBMT database
Level 4
level 3
question
score
Assessment(1)
As many entries as new assessments
[CIC] [PatId] [DoAssess] Hg WBC …
Questionnaire
As many entries as infections studied
[CIC] [PatId] [DoAssess] [Question] Score …
The European Group for Blood and Marrow Transplantation