Download MDR1 - Alpine Animal Hospital

Alpine Animal Hospital
Debra M. Taylor, D.V.M.
Patti A. Tuck, D.V.M. Emily A. Lewis, D.V.M.
2202 E. M-32
Gaylord, MI 49735
(989)732-6427
(989)732-4561 Fax
Email: [email protected]
www.alpineanimalhospitalmi.com
Multidrug Sensitivity in Dogs
Many herding breed dogs have a genetic predisposition to adverse drug reactions involving over a dozen
different drugs. The most serious adverse drug reactions involve several antiparasitic agents (ivermectin,
milbemycin and related drugs), the antidiarrheal agent loperamide (Imodium), and several anticancer
drugs (vincristine, doxorubicin, others). These drug sensitivities result from a mutation in the multidrug
resistance gene (MDR1 gene). At Washington State University's College of Veterinary Medicine you can test
your dog for multidrug sensitivity and prevent serious adverse drug reactions. We can work with your
dog’s veterinarian to find appropriate drug doses or alternative drugs for your dog based on results of
MDR1 testing.
The Partnership for Preventive Healthcare, is an initiative jointly sponsored by the American Animal
Hospital Association and the American Veterinary Medical Association. Together the two associations offer
a set of Canine and Feline Preventive Healthcare Guidelines. One of the important recommendations is that
dog owners use genetic testing—like the MDR1 test —as part of an overall healthcare plan for their pets.
Most Commonly
Affected Breeds
Australian Shepherd
IMPORTANT NOTICE
The discovery of the mutation of the multi-drug
Australian Shepherd (Mini)
resistant gene (mdr1), establishment of testing
Collie
procedures, and development of all reagents
Long-haired Whippet
was made by Washington State University. It is
McNab
also a patent protected diagnostic test offered
Silken Windhound
exclusively by Washington State University that
has not been licensed to any other entity in the
United States. It is licensed in Australia and
Europe. Any unlicensed use or marketing of the
patented test is a violation of federal statute
under 35 u.s.c. 271. Unless testing is conducted
by Washington State University's Veterinary
Clinical Pharmacology Laboratory, Washington
State University cannot control quality and
accuracy and consumers may risk receiving
inaccurate results.