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Table 3: Amsterdam criteria II • Three or more family members with HNPCC-related cancers*, one of whom is a first degree relative of the other two. • Two successive affected generations ( one of the patients is a first degree family member of the other patients). • One or more of the HNPCC-related cancers* diagnosed under age 50 years. • Familial adenomatous polyposis (FAP) has been excluded. * colorectal carcinoma, endometrial carcinoma, and other related cancer: small bowel, transitional cell carcinoma of the upper urinary tract, stomach, ovarian, brain( Turcot syndrome) and sebaceous gland adenomas or keratoachantomas ( Muir-Torre sundrome)