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Learning about cell differentiation using blood cells
Transcribe the following DNA sequences into RNA.
1. TACAGACAACAACAAAAAGAAAAAGAAGAAAGAAAACAAATT
2. TACAAAGAAAAAGAACAAAGAGAAAAAAAAAAACAAGAAATT
3. TACGAAGAAAGACAACAAAAAAAAAAACAAGAAAGAAGAATT
Translate your RNA sequences into protein sequences using the following key. Make a bead chain using
the colors from the amino acid key.
AUG (start codon): Met-Methionine
UUU: Phe-Phenylalanin
CUU: Leu-Leuicine
GUU: Val-Valine
UCU: Ser-Serine
UAA (stop codon)
The amino acid sequences you created are below, with the protein named.
Hemoglobin- Met-Leu-Leu-Ser -Val-Val-Phe-Phe-Phe-Val-Leu-Ser-Ser-UAA
Platelet Dervied Growth factor (PDGF)- Met- Ser-Val-Val-Val-Phe-Leu-Phe-Leu-Leu-Ser-Phe-ValUAA
Myeloperoxidase (MPO)- Met-Phe-Leu-Phe-Leu-Val-Ser-Leu-Phe-Phe-Phe-Val-Leu-UAA
Assign the name of the protein to each amino acid chain you created.
Of these three proteins, which do you think is expressed in the platelet cells? White blood cells?
Red blood cells? Why?
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