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Circulatory system General outline Heart Blood vascular system Arteries Capillaries veins Lymphatic capillaries Lymphatic vascular system Lymphatic vessel Lymphatic ducts Capillaries A single layer of endothelial cells LM basement membrane A few connective tissue (pericytes) Continuous capillary EM Fenestrated capillary Sinusoid Capillaries Continuous C. Fenestrated C. Sinusoid Continuous capillary: distributed in muscle tissue, brain, lung and connective tissue, etc. endothelial cell: large number of pinocytotic vesicles, no pores, exist cell junctions between the endothelia basement membrane: integrity Continuous capillary Fenestrated capillary: distributed in the kidney glomerulus, mucosa of gastrointestine, some endocrine glands endothelial cells: present abundant pores, have or haven’t diaphragm on them basement membrane: continuous Fenestrated capillary Sinusoid: distributed in liver, spleen, and some endocrine glands a greatly enlarged diameter endothelial cell: intercellular clefts are large between cells, many pores without diaphragm absence of a continuous basement membrane Sinusoid Artery transport blood from heart to capillaries according to their size, structure and function are classified Large artery Medium-sized artery Small artery arteriole Medium-sized artery: muscular artery Tunica intima Endothelium Subendothelial layer: LCT Internal elastic lamina: clear Tunica media: contain 10~40 layers of circular smooth muscle External elastic lamina Tunica adventitia LCT: contain vasa vasorum Medium-sized artery Large artery: elastic artery subendothelial layer is thicker with a few smooth muscles tunica media is thick, contains a lot of circular elastic membrane internal and external elastic lamina are not distinguished tunica adventitia are thiner Large artery Small artery: muscular artery and peripheral resistance vessel internal elastic lamina is clear, while external elastic lamina is not distinguished the media contains 3~9 layers of smooth muscles Vein large lumen, thin wall, irregular internal and external elastic lamina are not clear tunica media is thin, with a few elastic fibers and smooth muscles tunica adventitia is thick some veins have valves Heart a muscular organ that contracts rhythmically pump blood through the circulatory system The wall of heart Endothelium endocardium Subendothelial layer Subendocardial layer myocardium: thickest layer, consists of cardiac muscle LCT: contain adipose tissue epicardium Methothelium Impulse generating and conducting system of the heart: Pacemaker cells: heartbeat generating Purkinje cells (bundle cell): distributed in subendocardial layer, larger than cardiac muscle cells Transitional cells: transmit impulse Purkinje cell Cardiac cell