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CHINESE MEDICINAL BIOTECHNOLOGY Bimonthly Established in December 2006 Responsible Institution Ministry of Health of the People’s Republic of China Sponsor China Medicinal Biotech Association 7B Zaojunmiao Road, Haidian District, Beijing 100081, China Editing Editorial Board of Chinese Medicinal Biotechnology Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences 1#, Tian Tan Xi Li, Beijing, 100050, China Email: [email protected] http://www.cmbp.net.cn Editor-in-Chief ZHAO Kai(赵铠) Managing Director SHENG Feng-nian(盛丰年) Publishing Publishing House, Chinese Medicinal Biotechnology 7B Zaojunmiao Road, Haidian District, Beijing 100081, China Tel: 0086-10-62135779 Fax: 0086-10-62115976 Email: [email protected] Printing Beijing Zhongke Printing Limited Company Overseas Distributor China International Book Trading Corporation P. O. Box 399, Beijing, China Code No. BM4275 Mail-Order Publishing House, Chinese Medicinal Biotechnology 7B Zaojunmiao Road, Haidian District, Beijing 100081, China Tel: 0086-10-62135779 Fax: 0086-10-62115976 Email: [email protected] Volume 6, Number 2 April 10, 2011 CONTENTS OF SELECTED ARTICLES Editorial Advances in microbial drug research and development …………………… 81 SI Shu-yi, JIANG Wei, BAI Shuo-ke Original Articles Expression and the physical and chemical characterizations studies of two recombinant human serum albumin/interferon-α (2a; 2b) fusion proteins with long-acting bio-function ……………………………… 84 FU Yan, HAN Guo, YANG Xiao-nan, FU Yu-song, XING Jing, HU Jun-xia, CHEN Ying, YUN Wen-qi, YU Zai-lin Observation of viability and BMP-2 secretion of three different microcapsulated adult stem cells transfected with BMP-2 gene ……… 96 SHEN Yang, ZHANG Shu-hong, TANG Ting-ting Carboxyamidotriazole and low dose dexamethasone significantly inhibit the growth of A549 xenograft tumors …………………………… 101 JU Rui, WU Dan-wei, GUO Lei, LI Juan, YE Cai-ying, ZHANG De-chang Effects of the combination of anti-human DR5 monoclonal antibody and 5-Fluorouracil on the proliferation of colorectal cancer cells in vitro …………………………………………… 106 GAO Xu, ZHOU Zheng, SHEN En-yun, JING Xiao-juan, GUO Lei-ming, WANG Xian-bin, SUN Jin-wen, DU Yun-feng Effect of Yuchangning capsule releasing drug respectively in stomach and colon on ulcerative colitis in rats caused by TNBS ………………… 111 XIE Xing-liang, SHENG Yan-mei, HAN Li, YANG Ming Isolation, structure identification and anti-tumor activity of potential small-molecular inhibitor of human Aurora-B kinase from microbial nature products ……………………………………………… 116 NIU Yu-qiang, JIANG Wei, YU Li-yan, WANG Yan-chang, LI Yan, SI Shu-yi The construction and transformation of Ginseng SQE gene interference vector …………………………………………………………… 121 YU Yan-ting, REN Li, SUN Chun-yu, JIANG Shi-cui, WANG Yi, ZHANG Mei-ping Reviews Insights into the mechanisms of molecular therapy for heart failure …… 127 XIONG Qin-mei, HONG Kui Advances in clinical research of new drug for hepatocellular carcinoma ………………………………………………… 131 JIA Jin-bin, NI Shu-xin CSSN ISSN 1673-713X CN 11- 5512 / R Research progress on biofilm formation and detection of coagulase-negative Staphylococcus …………………………………… 134 Copyright© 2011 by the Publishing House, Chinese Medicinal Biotechnology Research progress on new dosage forms of resveratrol …………………… 138 All articles published represent the opinions of the authors, not reflecting the official policy of the China Medicinal Biotech Association or the Editorial Board of Chinese Medicinal Biotechnology, unless this is clearly specified. Technology and Method Production of crocin by the bubble column bioreactor …………………… 141 JIANG Mei-juan, WANG Hua-qiang, WANG Dan-dan, LIANG Bing LI Wan-zhong, TIAN Jing-zhen CHEN Shu-an, WANG Xiao-dong, YUAN Xiao-fan, ZHAO Bing, WANG Yu-chun Study on accelerated release testing method of dutasteride PLGA microspheres ………………………………………… 145 WANG Kai-yuan, GAO Yong-liang