Download Chaulmoogra oil

Anti-leprotics
Chaulmoogra oil
OBJECTIVES
On completion of this period you would be able to
learn about
The monograph of the anti-leprotic Drug
CHAULMOOGRA OIL
Fig.44.1 Hydnocarpus Anthelmintica
CHAULMOOGRA OIL
Syn : Hydnocarpus oil, Gynocardia oil (English)
Nirodi vittula nune (Telugu)
• Biological Source :
Fixed oil from seeds of
Hydnocarpus anthelmintica
Hydnocarpus heterophylla
• Family : Flacourtriaceae
• Geographical Sources :
Myanmar, Thailand, Sri Lanka
Bangladesh, East India
(Assam and Tripura)
Fig.44.2
Hydnocarpus tree
PREPARATION
Seeds (Sub-ovoid, obtuse and angular, 2cm length,
contain 40-45% fixed oil)
Graded, machine decorticated, hydraulic pressed
Oil
Filter
Yellow oil with characteristic odour and acrid taste
STANDARDS
•
Acid Value
•
Saponification Value : 195-213
•
Iodine value
: not less than 13
: 93-104
CHEMICAL CONSTITUENTS
Esters of unsaturated fatty acids of
• Chaulmoogric Acid (27%)
• Hydnocarpic Acid (48%)
• Glycerides of Palmitic Acid
USES
• The unsaturated fatty acids have strong
bactericidal effect against
Mycobacterium leprae
Mycobacterium tuberculosis
• Useful in the treatment of Tuberculosis
Leprosy, Psoriasis and Rheumatism
FOR EXTERNAL USE ONLY
Fig.44.4 Chaulmoogra oil
STORAGE AND SUBSTITUTES
• Storage :
Stored in closed containers in cool place
and protect from light
• Substitutes:
Widely substituted by
Hydnocarpus weightiana
Hydnocarpus alpine
SUMMARY
In this class we learnt about
Chaulmoogra oil
Contains unsaturated fatty acids
Effective against Leprosy Caused by
Mycobacterium leprae
QUIZ
1. The active constituents of Chaulmoogra oil are
a) Alkaloids
b) Unsaturated fatty acids
c) Glycosides
d) Tannins
QUIZ
2. Leprosy is caused by the organism
a) Mycobacterium leprae
b) Plasmodium vivax
c) Entamoeba hystolytica
d) None of the above
FREQUENTLY ASKED QUESTIONS
1. Write the Botanical Source and Chemical
Constituents of Chaulmoogra
2. Give example for an Anti-leprotic drug.
Write the Botanical Source and the Chemical constituents