Download Organic Chemistry II

Organic Chemistry II
Welcome
Dr. Tim Schoof
Instructor / Host
Course Outline
1. Introduction
2. Review of Major Concepts in Organic I
3. Alkenes & Alkynes (Chapter 7)
A. Physical Properties of Alkenes & Alkynes
B. E-Z System
C. Relative Stabilities of Alkenes &
Cycloalkenes
D. Zaitsev’s Rule & Hofmann Rule
Course Outline Cont.
3. Alkenes & Alkynes (Chapter 7)
E.
F.
G.
H.
I.
J.
Dehydration of Alcohols
Vicinal (Vic) & Geminal (Gem)
Terminal Alkynes
Hydrogenation of Alkenes
Syn & Anti Additions
Index of Hydrogen Deficiency
Course Outline Cont.
4. Addition Reactions (Chapter 8)
A.
B.
C.
D.
E.
Mechanism
Markovnikov’s Rule
Acid-Catalyzed Hydration
Variations
Oxidative Cleavage of Alkenes
Course Outline Cont.
5. Radical Reactions (Chapter 10)
A.
B.
C.
D.
E.
F.
Description
Importance in Biology, Medicine & Industry
Mechanism
Selectivity of Halogens
Anti-Markovnikov Reaction
Ozone Depletion & CFC’s
6. Test 1
Course Outline Cont.
7. Spectroscopy (Chapters 9, 2, 13)
A.
B.
C.
D.
E.
F.
G.
Electromagnetic Spectrum
General Principle
Infrared Spectroscopy (Chapter 2)
Ultraviolet Spectroscopy (Chapter 13)
NMR Spectroscopy (Chapter 9)
MRI Spectroscopy (Chapter 9)
Structural Analysis
Course Outline Cont.
8. Alcohols & Ethers (Chapter 11)
A.
B.
C.
D.
E.
Important Alcohols & Ethers
Physical Properties
Synthesis of Alcohols form Alkenes
Dehydration Synthesis (Condensation)
Phase-Transfer Catalysis
Course Outline Cont.
9. Carbonyl Compounds (Chapter 12)
A.
B.
C.
D.
Carbonyl Containing Compounds
Nucleophilic Addition Reactions
Oxidation-Reduction (Redox) Reactions
Organometallic (Grignard Reagents) Note:
overview only
10. Test 2
Course Outline Cont.
11. Conjugated Systems (Chapter 13)
A.
B.
C.
D.
Classification
Resonance Review
Stability of Conjugated Dienes
Kinetic vs. Thermodynamic Control
Course Outline Cont.
12. Aromatic Compounds (Chapter 14)
A. Aliphatic vs. Aromatic
B. Nomenclature
i. Ortho, Meta, Para
ii. Annulenes
C. Stability
i. Aromatic
ii. Antiaromatic
iii. Nonaromatic)
D. Huckel’s Rule
Course Outline Cont.
12. Aromatic Compounds (Chapter 14)
E. Heterocyclic Aromatic Compounds
F. Aromatic Compounds in Biochemistry
G. Energy Transport
Course Outline Cont.
13. Electrophilic Aromatic Substitution
Reactions (Chapter 15)
A. General Mechanism
B. Specific Examples
C. Effect of Substituents
i.
ii.
iii.
iv.
Activators
Deactivators
Ortho-Para Directors
Meta Directors
D. Reaction Scenarios
Course Outline Cont.
14. Odds & Ends
A.
B.
C.
D.
E.
F.
G.
Reactivity of Aldehydes & Ketones
Hemiacetals & Hemiketals
Enol
Tautomers
Carboxylic Acid Derivatives
Decarboxylation
Thio Group
Course Outline Cont.
14. Odds & Ends Cont.
A.
B.
C.
D.
Amines vs. Amides
Biologically Important Amines
Chemotherapy
Biochemistry Prep. (Glycolysis)
15. Test 3