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CV Joachim Reidl: Personal Name Joachim Reidl Address Institute of Molecular Biosciences Karl-Franzens-University Graz Humboldtstrasse 50 8010 Graz, Austria phone: 0043 316 380 1978 fax: 0043 316 380 9019 e-mail: [email protected] web-page: https://molekularbiologie.uni-graz.at/de/forschen/forschungsbereiche/infektionsbiologie// Date of Birth 09/11/1961 Nationality Germany A. Main Interests: Molecular mechanisms of environmental and host adaptation of human-pathogenic bacteria; molecular mechanisms of gene regulation, physiology and pathogenesis of obligate and facultative host-associated bacteria. Further interests are basic protein interaction and structural/function relationships and mechanisms. Main organisms are Gram-negative pathogenic bacteria, such as e.g. Haemophilus influenzae und Vibrio cholerae. B. Education: Institute Qualification Field 1988 University of Konstanz Diplom Biology 1992 University of Konstanz Dr. rer. nat. Microbiology/Molecular Genetic 2001 University of Wuerzburg Habilitation Microbiology C. Research / Professional: 1989-1992 Diplom and PhD student, Department for Microbiology, University of Konstanz, Konstanz Germany. 1993-1995 Post-Doc at Harvard Medical School, Harvard University, Boston, USA. 1996-2003 Junior group leader, Center for Infectious Research Universiy of Wuerzburg, Wuerzburg, Germany. 2004-2007 Associate-Prof. Institut for Hygiene and Microbiology, Julius-Maximilians University of Wuerzburg, Wuerzburg, Germany. Since 2007 Professor for Microbiology, Institute Molecular Biosciences, University of Graz, Graz, Austria. 1 D. Grants: 1996-2003 BMBF program for the junior group leader projects, Bavaria, University of Wuerzburg. “Virulence of Gram-negative bacteria." 2001-2006 DFG-grant, Re1561/1-1, 1-2, Nicotinamide-Adeninedinucleotide (NAD)-uptake and physiology of Haemophilus influenzae. 2003-2006 DFG-grant, Re1561/2-1, Vibrio cholerae: Characterization of the physiology of the outer membrane and new approaches of differential gene regulation. 2004-2007 BMBF PathoGenoMic, FörderKenz. 0313134, Target identification of pathogens of the respiratory tract. 2007-2012 DFG-grant, Re1561/3-1, Haemophilus influenzae: Pathogenität und wirtsabhängiger, bakterieller Metabolismus. DFG-grant, Re1561/4-1 Membrane stress and ToxR-mediated virulence of Vibrio cholerae. 2011-2014 ERA-NET FWF I 662-B09, PathoGenoMics 3rd. Call, MobileGenomics, 2016-2019 FWF-grant P 29405-B30 Activation mechanisms of the transcriptional regulator complex ToxRS in Vibrio cholerae. F. Publications: Source: Pub-Med Database (06/2016): 54 peer-reviewed papers Ongoing/Submitted: - Lichtenegger S, Bina B, Durakovic S, Glaser P, Tutz S, Schild S, Reidl J. 2016 Serum resistance and phase variation of a nasopharyngeal non-typeable Haemophilus influenzae isolate. Submitted Int J Med Microbiol/IJMM_2016_111. - Wurm P, Tutz S, Mutsam B, Heyne B, Grabner C, Kleewein K, Halscheidt A, Vorkapic D, Schild S, Reidl J. 2016. Stringent factor and proteolysis control of sigma factor RpoS expression in Vibrio cholerae. Submitted Int J Med Microbiol/IJMM_2016_72. Last 5 Years: 1. 2. 3. Reidl, J. 2016. Outer membrane vesicles biosynthesis in Salmonella: Is there more to Gram-negatives? mBio00940. In Press. Pressler K, Vorkapic D, Lichtenegger S, Malli G, Barilich BP, Cakar F, Zingl FG, Reidl J, Schild S. 2016. AAA+ proteases and their role in distinct stages along the Vibrio cholerae lifecycle. Int J Med Microbiol. In press doi:10.1016/j.ijmm.2016.05.013. Roier S, Zingl GZ, Cakar F, Durakovic S, Kohl P, Eichmann TO, Klug L, Gadermaier B, Weinzerl K, Prassl R, Lass A, Daum G, Reidl J, Feldman MF, Schild S. 2016 A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria. Nature Commun. doi:10.1038/ncomms10515. 2 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. Leitner DR, Lichtenegger S, Temel P, Zingl FG, Ratzberger D, Roier S, Schild-Prüfert K, Feichter S, Reidl J, Schild S. 2015 A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles. Front Microbiol. 6:823. doi: 10.3389/fmicb.2015.00823. Gumpenberger T, Vorkapic D, Zingl FG, Pressler K, Lackner S, Seper A, Reidl J, Schild S. 2015 Nucleoside uptake in Vibrio cholerae and its role in the transition fitness from host to environment. Mol Microbiol. doi: 10.1111/mmi.13143. Tchoupa AK, Lichtenegger S, Reidl J, Hauck CR. 2015 Outer membrane protein P1 is the CEACAMbinding adhesin of Haemophilus influenzae. Mol Microbiol. doi: 10.1111/mmi.13134. Reidl J, Monsó E. 2015 Glucocorticoids and antibiotics, how do they get together? EMBO Mol Med. doi: 10.15252/emmm.201505336. Glanzer S, Pulido SA, Tutz S, Wagner GE, Kriechbaum M, Gubensäk N, Trifunovic J, Dorn M, Fabian WM, Novak P, Reidl J, Zangger K. 2015 Structural and functional implications of the interaction between macrolide antibiotics and bile acids. Chemistry. doi: 10.1002/chem.201406413. Roier S, Blume T, Klug L, Wagner GE, Elhenawy W, Zangger K, Prassl R, Reidl J, Daum G, Feldman MF, Schild S. 2015 A basis for vaccine development: Comparative characterization of Haemophilus influenzae outer membrane vesicles. Int J Med Microbiol. 305:298-309. doi: 10.1016/j.ijmm.2014.12.005. Salem W, Leitner DR, Zingl FG, Schratter G, Prassl R, Goessler W, Reidl J, Schild S. 2014 Antibacterial activity of silver and zinc nanoparticles against Vibrio cholerae and enterotoxic Escherichia coli. Int J Med Microbiol. doi: 10.1016/j.ijmm.2014.11.005. Seper A, Pressler K, Kariisa A, Haid AG, Roier S, Leitner DR, Reidl J, Tamayo R, Schild S. 2014 Identification of genes induced in Vibrio cholerae in a dynamic biofilm system. Int J Med Microbiol. 304:749-763. Lichtenegger S, Bina I, Roier S, Bauernfeind S, Keidel K, Schild S, Anthony M, Reidl J. 2014 Characterization of lactate utilization and its implication on the physiology of Haemophilus influenzae. Int J Med Microbiol. 304:490-498. Seper A, Hosseinzadeh A, Gorkiewicz G, Lichtenegger S, Roier S, Leitner DR, Rohm M, Grutsch A, Reidl J, Urban CF, Schild S. 2013. Vibrio cholerae evades neutrophil extracellular traps by the activity of two extracellular nucleases. PLoS Pathog 9:e1003614. Leitner DR, Feichter S, Schild-Pruefert K, Rechberger GN, Reidl J, Schild S. 2013. Lipopolysaccharide modifications of a cholera vaccine candidate based on outer membrane vesicles reduce endotoxicity and reveal the major protective antigen. Infect Immun 81:2379-2393. Roier S, Fenninger JC, Leitner DR, Rechberger GN, Reidl J, Schild S. 2013. Immunogenicity of Pasteurella multocida and Mannheimia haemolytica outer membrane vesicles. Int J Med Microbiol 303:247-256. Moisi M, Lichtenegger S, Tutz S, Seper A, Schild S, Reidl J. 2013. Characterizing the hexose-6phosphate transport system of Vibrio cholerae, a utilization system for carbon and phosphate sources. J Bacteriol 195:1800-1808. Roier S, Leitner DR, Iwashkiw J, Schild-Prufert K, Feldman MF, Krohne G, Reidl J, Schild S. 2012. Intranasal immunization with nontypeable Haemophilus influenzae outer membrane vesicles induces cross-protective immunity in mice. PLoS One 7:e42664. Fengler VH, Boritsch EC, Tutz S, Seper A, Ebner H, Roier S, Schild S, Reidl J. 2012. Disulfide bond formation and ToxR activity in Vibrio cholerae. PLoS One 7:e47756. Seper A, Fengler VH, Roier S, Wolinski H, Kohlwein SD, Bishop AL, Camilli A, Reidl J, Schild S. 2011. Extracellular nucleases and extracellular DNA play important roles in Vibrio cholerae biofilm formation. Mol Microbiol 82:1015-1037. 3