Download Midsemester Presentation 3422 kb Thursday

Team Members:
Team Leader- Adam Goon
BSAC- Mike Conrardy
BWIG- Andrew Bertram
Communicator- Joel Webb
Advisor- Professor John Webster
Client- Tim Hacker, PhD
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Background Information
Problem statement
Design Requirements
Stem cell injections
Design Alternatives
◦ Balloon
◦ Multiple Needle
◦ Guided
Design Matrix
Proposed Design
Future Work
• Current research is being conducted
injecting stem cells into dead heart tissue.
• Research is done using pigs.
• The catheter being used currently has a
single needle on the tip and must be
moved for every injection site.
•2.7 mm diam, 27 gauge needle, 4 to 6 mm
depth of needle
• Current Devices
• Myostar by Biosense-Webster
•Stiletto by Boston Scientific
Left
Ventricle
http://www.thefinalsprint.com/2007/02/hearthealth-and-marathon-running-preparation-is-key/
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Time consuming
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Needle depth is
inconsistent
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Flexibility
◦ Reposition the
catheter
◦ Single injection
◦ Heart is beating
◦ Difficult to position
http://www.med.upenn.edu/mcrc/patel_lab/
documents/LVCatheterUsingEtOHinSwineJICE.
pdf
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Multiple, quick injection
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Small enough for arteries
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◦ >1 injection per catheter location
◦ < 14 French diameter (4.66 mm)
Flexible to get through aorta
Consistent depth of needle
Accurately position the device
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Inject contrast agent
Take still image and mark contrast agent
Insert injection catheter
Determine placement and protrude needle
Observe electrical activity of heart on ECG
 Insertion of needle causes increase in
activity
 Wait for activity to stabilize
Stop ventilator for injection
Inject stem cells
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#1 Two layers
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Fills most of ventricle
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Simultaneously injects
stem cells to large area
◦ Polyethylene Terephthalate
◦ Rubber tubing
◦ Needles attached to rubber
exterior
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#2 Multiple needle
catheter
◦ Preformed needle shape
◦ Single location
◦ Simultaneous injection
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Similar to an ablation
catheter
http://www.angiodynamics.com/pages/p
roducts/starburst_talon.asp
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#3, 3 components
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Slotted outer component
Track for guidance
Inner needle injection
catheter
Outer component rests
against apex of heart
Use holes for multi-level
injections using
preformed curved
catheter
Cost
(0.05)
Time
Reduction
(0.30)
Accuracy
of
Injection
(0.30)
Flexibility
(0.05)
Ease of
Manufacturing
(0.30)
Total
#1
Balloon
1
(0.05)
9
(2.7)
4
(1.2)
8
(0.4)
1
(0.3)
4.65
#2
Guided
5
(.25)
7
(2.1)
8
(2.4)
5
(.25)
4
(1.2)
6.2
#3
Multiple
Needle
7
(.35)
4
(1.2)
6
(1.8)
6
(.3)
8
(2.4)
6.05
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360o movement of exterior
component
Predetermined angle of
injection
Track moveable to
different holes through
handle
◦ Screw mechanism
◦ Full turn causes track to
move to next hole
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Contact companies for guidance on
development
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Finalize design of handle
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Improve consistency of depth of needle
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Create prototype and conduct testing
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http://www.madehow.com/Volume-6/Angioplasty-Balloon.html
http://www.angiodynamics.com/pages/products/starburst_talon.asp
Callans, D.J., Ren, J.F., Narula, N., Patel, V., Michele, J., Gelzer, A., Dillon, S.M. Left Ventricular Catheter
Ablation using Direct, Intramural Ethanol Injection in Swine. Journal of Interventional Cardiac
Electrophysiology, 6, 225–231.
http://www.thefinalsprint.com/2007/02/heart-health-and-marathon-running-preparation-is-key/