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Transcript 
GOODSELL’S MOLECULE OF THE MONTH
HEMOGLOBIN QUESTIONS
Name: _______________________
www.bv229.k12.ks.us/biophilia/gsmm.htm
1. What is the name of the protein pigment that transports oxygen in the blood?
Describe its general structure, including information on where oxygen bonding
occurs.
2. How are the bonding of oxygen and carbon monoxide to hemoglobin different?
3. As you know, blood transfusions are complicated by the antigens found on the
surface of red blood cells. What about hemoglobin structure makes it difficult
to make artificial blood from pure hemoglobin (no foreign antigen problem)?
4. Although life has evolved a variety of different hemoglobin structures, what
amino acid is most conserved (found in every example)? Why is this
important?
5. Describe how the structure of hemoglobin cycles through its saturated
oxyhemoglobin state to its deoxyhemoglobin state. Can it be said that the
hemoglobin molecule is breating?
6. What molecular mutation causes sickle cell anemia?
molecular changes result in a sickle red blood cell?
7. What is the problem in Thalassemia?
How does these
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