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PREVALENCE OF PROGRESSION TO VASCULAR DEMENTIA IN PATIENT WITH CEREBROVASCULAR DISEASE Fujihara S, Brucki SMD. Hospital Santa Marcelina- São Paulo- SP Objectives:To evaluate the prevalence of dementia following ischemic stroke for 1 year in a tertiary hospital of east of São Paulo. To verify socio-demographic and risk factors for development of cognitive impairment or dementia. Correlate the cognitive status with anatomic locations of infarction and areas of hiperintensity of white matter (MRI). Methods:We will evaluate 120 patients, consecutive and prospectvely, admitted in the emergency sector of the Santa Marcelina Hospital with sudden neurologic deficits. The initial assessment will perform within 72 hours of the admittion and will include sociodemographic information, clinical history, risk factors for cerebrovascular diseases and clinical and neurologic examinations. Laboratory determinations (including thyroid hormones, VDRL and FTA- abs reactions, B12 vitamin, homocystein, Chaga´s serology, folate levels) and other diagnostic tests ( including EKG) will perform. CT scans at entry and MRI scan. We will exclude from the study patients: preexisting dementia, severe aphasia, concomitant neurologic disorder that could affect cognitive function (i.e, Parkinson disease), or a severe comorbid medical illness (i.e, terminal cancer), younger than 40 years, inflammatory process and tumors in the CT or MRI scan of the brain. Patients will be evalueted by a neuropsychological battery including the MMSE, Geriatric Depression Scale, Rankin Scale, Barthel Index , NIHSS (National Institute of Health) and IQCODE ( Informant Questionnaire on Cognitive Decline in the Elderly). Follow-up assessment will be performed subsequently after 3 months and 1 year of the vascular event and will include other neuropsychological tests: Trail Making Test Part A and B, Trail Making Colors, Digit Span Forwards and Backwards, Picture’s Test from Brief Battery, Clox 1 and 2, Proverbs Tests, Luria three–step Test, Pfeffer Test, Cancellation Test, Token Test and Neuropsychiatric Inventory.
