Download Which gene? - Confluence

Digital Enterprise Research Institute
Solving Problems with Biology …
via Linked Data
 Copyright 2010 Digital Enterprise Research Institute. All rights reserved.
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21st Century will be the Age of Biology
Digital Enterprise Research Institute
Climate Change
Nutritious Food
Sustainable
Energy
Disease and
Ageing
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The most amazing molecule
Digital Enterprise Research Institute
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4 letter code
- Adenosine
- Timine
- Citosine
- Guanine
2 chains, exact
mirrors!
Able to make
copies of itself!
Same genetic code for all
living cells!
Making a human
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Biology explained
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Creating Synthetic Biology
Digital Enterprise Research Institute
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Genetic engineering… oversimplified
DNA!
Bio-fuel
producing
gene
CO2
Biofuel
BioHacking = Do-it-yourself Biology
by amateurs!
Digital Enterprise Research Institute
Bio
Bio
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Executable Cell Biology
Digital Enterprise Research Institute
Cell and computers are not that different
Activator genes
Repressor genes
Src: http://gene-therapy.yolasite.com/process.php
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Where does LD fit in all of this?
Digital Enterprise Research Institute
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Let’s make a “virtual” experiment
Which gene?
Digital Enterprise Research Institute
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Non-toxic
biofuel
Not-soluble H2O
?gene
CO2
Not that simple…
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?sugar
?
?
?
Biofuel
U de Lichtenberg et al. Science 2005;307:724-727
?gene
The Linked Data Cloud
Digital Enterprise Research Institute
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“Life sciences will drive adoption of the Semantic Web, just as highenergy physics drove the early Web.”
- BioIT World, 2005
Linked Data for Understanding Cancer
Digital Enterprise Research Institute
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Link the Data, cure the disease
Digital Enterprise Research Institute
What your doctor is not
telling you!
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Diseasome Drugbank ClinicalTrial
The diseasome project
Digital Enterprise Research Institute
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Biosurveillance!! Today!
Digital Enterprise Research Institute
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Linked Data to track E. coli infection
Digital Enterprise Research Institute
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UK
E. coli
Germany
E. coli
Nothing in Biology Makes Sense Except in
the Light of Evolution (Dobzhansky, 1973)
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Source:
http://www.nytimes.com/imagepages/2007/01/22/science/20070123_SCI_ILLO.ht
ml
Digital Enterprise Research Institute
Toss the details, understand the patterns
Digital Enterprise Research Institute
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Navigating the genetic landscape with simplified views
Source: http://www.sciencemag.org/content/327/5964/425.full
Where is the data?
Digital Enterprise Research Institute
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21st Century Biology belongs to BioHackers!
Digital Enterprise Research Institute
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