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Transcript 
Biosynthesis of peptide hormones
DNA (gene)
Hormone
Protein secretory pathway
Protein secretory pathway
rough endoplasmic reticulum
Secretory pathway
rough
ER
Signal sequences & SRP
Signal sequences & SRP
SRP (signal
recognition
particle)
Multiple hormone cleavage products
pro-opiomelanocortin polypeptide (POMC)
b-lipotropin
ACTH
b-endorphin
CLIP
g -MSH
a-MSH
g -lipotropin
MET-enk
b -MSH
Steroid hormone synthesis
• tissues involved in steroid
hormone synthesis:
testosterone
estradiol
Steroid hormone synthesis
• synthesis occurs in
cholesterol
Biosynthesis of steroids
cholesterol (C27)
Gluco- and mineralo-corticoid synthesis
glucocorticoid
mineralorticoid
Androgen & estrogen synthesis
androgen
estrogens
Vitamin D synthesis
UV light
liver, kidney
Thyroid hormone synthesis
• thyroid hormone synthesis
• forms of active thyroid hormone:
Thyroid hormone biosynthesis
Biosynthesis of eicosanoids
arachidonic acid
Biosynthesis of eicosanoids
Anti-inflammatory drugs & eisosanoids
fatty acids
phospholipase A
arachidonic acid
thromboxane
leukotriene
inflammation response
Hormone delivery
• endocrine:
• paracrine:
• autocrine:
• neuroendocrine:
Plasma transport of hormones
Hormone turnover
• typical half-life
• peptide hormones
• steroid & thyroid hormones
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