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Respiratory Diseases: Chronic Obstructive Pulmonary Disease Case Study Kevin Hernandez October 7th, 2013 Mrs. Stella Bernhardt is a 62-year-old Caucasian female admitted to the hospital with an acute exacerbation of chronic obstructive pulmonary disease, including an increased shortness of breath and a possible upper respiratory infection. She lives with her husband, aged 68 with a past medical history of CAD. Mrs. Bernhardt is 5’ 3” and weighs 119 lbs, with a BMI of 21.1. Her education includes two years of college, she is a retired office manager, and she is Methodist. She has four children, and had two miscarriages in the past. Mrs. Bernhardt has never been exposed to occupational hazards related to COPD. However, she smoked a pack of cigarettes a day for 46 years, recently quitting a year ago. She was diagnosed with stage 1 chronic obstructive pulmonary disease (emphysema) five years ago and has a history of bronchitis and upper respiratory infections. Her mother and two of her aunts passed away from lung cancer. She currently takes Combivent – a mixture of ipratropium bromide (18mcg per inhalation) and albuterol sulfate (130 mcg per inhalation) – at home, two inhalations four times a day. Mrs. Bernhardt complains that her shortness of breath has recently worsened to the point where she can “hardly do anything for herself.” For example, her husband has to help her out of the shower at times. She states she has been coughing a lot of dark-colored phlegm. She also states her husband mentioned to her that she seemed confused and wonders if that has anything to do with her COPD. Mrs. Bernhardt states that she has a poor appetite. She feels too tired to eat after preparing a meal. Additionally, her coughing makes it very difficult for her to eat. Her appetite has also decreased in general; stating food simply does not taste good to her. She states her family believes she has become thin and although she has not weighed herself recently, her clothes fit her big. Her last recorded weight was 139 lbs a year ago, and she claims her usual body weight is 145-150 lbs. She wears dentures, although they fit loosely. She purposely avoids milk products because she was informed that they can cause an increase in mucus production. COPD patients are at risk for osteoporosis; vitamin D and calcium should be monitored to reduce the risk. According to her 24-hour recall, Mrs. Bernhardt is consuming 710 calories, 164 g carbohydrates, 5 g fiber, 9 g protein (5% of calories), 6 g fat (7.5% of calories). The Mifflin St. Jeor equation estimates she requires approximately 1350 kcals. The Harris-Benedict predicts approximately 1550 as her energy requirement. Providing 25-30 kcal/kg of weight, she would require 1600 calories. She should consume anywhere from 1350-1600 calories a day. Mrs. Bernhardt should consume 70-90 grams of protein per day. She should consume approximately 1 mL per calorie, however since she is retaining, fluid, she may need to be placed on a fluid-restricted diet. Nutrition Diagnosis: Impaired ability to prepare meals (NB-2.5) related to patient’s shortness of breath and fatigue during mealtimes as evidenced by a 20 lb weight loss in one year and a 24-hour recall revealing an intake significantly less than her required energy, nutrients, and fluid needs. Food and nutrition-related knowledge deficit (NB-1.1) related to misinformation about milk and dairy products as evidenced by an absence of calcium-rich foods in patient’s diet and confirmation of avoidance of these foods. Nutrition Intervention: Goals: o Remove challenges to a healthy diet. Patient will increase her energy and protein intake to at least 80% of her requirements. o Patient will learn about osteoporosis among COPD patients and preventative strategies. Patient will increase vitamin intake per day, particularly calcium intake to at least 900 mg per day Interventions: Skill development (E-2.5) to teach patient how to prepare smaller portions and to rest before eating. Goal: to combat fatigue and shortness of breath and increase intake. Recommend modifications (E-2.2) of types of food eaten and fortification of foods. Goal: patient will learn about consuming more nutrientdense food and fortifying food in order to consume more energy and protein. Comprehensive nutrition education (E-2.1) on importance of calciumcontaining foods and risk of osteoporosis among COPD patients. Goal: patient will consume more dairy foods and will learn about other calcium-containing foods. Supplement a multivitamin/mineral (ND-3.2.1) in order to reduce risk of vitamin deficiencies possible in COPD. Goal: patient will begin a multivitamin supplement regiment and increase her daily intake of important vitamins such as vitamins A, E, D, calcium, iron, and selenium. ADIME Format A(Assessment): Total Energy Intake (FH 1.2.1.1) ~ 710 kcals Total protein intake (FH 1.6.2.1) 9 grams and 5% of calories Knowledge (FH-3.1.1) about milk and mucus production is inaccurate Mealtime behavior (FH-4.4.7) patient fatigue during feeding process resulting in inadequate intake Height/weight/BMI (AD 1.1) Ht 5’3”; Wt 119 # BMI 21.1 Albumin (BD-1.11.1) 3.3 Nutrition-focused physical findings (PD-1.1.3) Cardio-pulmonary: shortness of breath, coughing, excessive phlegm Client History (CH-1.1.8) Tobacco use for 46 years, quit 1 year ago, 1 pack per day Estimate energy needs (CS 1.1.1) Current calorie intake is ~50% of her required 1550 kcal according to Harris-Benedict equation (CS 1.1.2) with activity factor of 1.3 Total protein needs (CS2.2.1) of 70-90 grams per day Estimated calcium needs (CS-4.2.1) of 1200-1500 mg per day. D (Diagnosis): (P) Self-feeding difficulty (NB-2.6) (E) related to patient’s shortness of breath and fatigue during mealtimes (S) as evidenced by a 20 lb weight loss in one year and a 24-hour recall revealing an intake significantly less than her required energy, nutrients, and fluid needs. (P) Food and nutrition-related knowledge deficit (NB-1.1) (E) related to misinformation about milk and dairy products (S) as evidenced by an absence of calciumrich foods in patient’s diet and confirmation of avoidance of these foods I (Intervention): Skill development (E-2.5) to teach patient how to prepare smaller portions and to rest before eating. Goal: to combat fatigue and shortness of breath and increase intake. Recommend modifications (E-2.2) of types of food eaten and fortification of foods. Goal: patient will learn about consuming more nutrient-dense food and fortifying food in order to consume more energy and protein. Comprehensive nutrition education (E-2.1) on importance of calcium-containing foods and risk of osteoporosis among COPD patients. Goal: patient will consume more dairy foods and will learn about other calcium-containing foods. Supplement a multivitamin/mineral (ND-3.2.1) in order to reduce risk of vitamin deficiencies possible in COPD. Goal: patient will begin a multivitamin supplement regiment and increase her daily intake of important vitamins such as vitamins A, E, D, calcium, iron, and selenium. M&E (monitoring & evaluation): Patient fatigue (FH-4.4.7) and Amount of Food (FH1.3.2.1) Criteria: Patient should be eating smaller meals so she can comfortably eat without fatigue. Total Protein intake (FH-1.6.2.1) Criteria: Patient requires protein to help her respiratory muscles breathe more effectively and avoid malnutrition. Multivitamin/multimineral intake (FH-1.7.1.12/1.7.2.9) , milk/dairy foods intake (FH-1.3.2.2) and avoidance of these foods (FH-4.2.1) Criteria: Patient requires adequate amounts of vitamin D and calcium to prevent risk of osteoporosis, but has history of avoiding foods that provide these nutrients. 1. Mrs. Bernhardt was diagnosed with stage 1 emphysema/COPD five years ago. What criteria are used to classify this staging? COPD is a progressive disease, worsening over time. As the disease progresses, the patient moves into different stages based on their symptoms and lung function. Lung function is measured as forced expiratory volume (FEV1), a measure of how fast air is expired from the lungs, and therefore, airflow obstruction. The FEV will measure >80% of normal function in stage I, 50-80% in stage II 30-50% in stage III <30% or <50% with symptoms in stage IV. Symptoms can range from a chronic cough with mucus in stage I to severe SOB, weight loss, and cyanosis in stage IV. A criterion for diagnosing COPD in general is a FEV1/FVC ratio of less than 70%; Mrs. Bernhardt’s ratio is at 46%. 2. COPD includes two distinct diagnoses. Outline the similarities ad differences between emphysema and chronic bronchitis. COPD is an umbrella term that consists of two separate coexisting conditions: chronic bronchitis and emphysema. They both create breathing difficulties and develop similar symptoms in the patient and are caused by similar factors including tobacco smoke and environmental pollutants. Chronic bronchitis refers to inflammation, irritation, and scarring of the bronchioles and increased production of mucus. Patients are usually normal weight. It is characterized by decreased airflow, dyspnea, hypoxemia, hypercapnia, and possibly cyanosis, clubbing, and secondary polycythemia. Emphysema refers to permanent structural damage and destruction of the alveoli. Emphysema patients tend to be thinner than those suffering from bronchitis. Aside from the typical causal factors of COPD, emphysema may be caused by a genetic deficiency of alpha-1-anytrypsin, a protein that protects the alveoli from hazards like tobacco smoke. Emphysema mostly impairs expiration, which then leads to dyspnea, shortness of breath, hypercapnia, and respiratory acidosis. Hypoxemia due to fatigue and exhaustion usually appears in the final stages of the illness. 3. What risk factors does Mrs. Bernhardt have for this disease? The most prominent risk factor for COPD is smoking. Although she has not smoked for a year, Mrs. Bernhardt smoked a pack a day for 46 years. She has a history of bronchitis and upper respiratory infections. Additionally, family history of lung cancer and COPD may be overlooked as a risk factor. 4. a. Identify symptoms described in the MD’s history and physical that are consistent with Mrs. Bernhardt’s diagnosis. Then describe the pathophysiology that may be responsible for each symptom. i. Dyspnea – caused by inflammation of brochioles and damage to alveoli. ii. Hypercapnia – elevated CO2 levels caused by the lack of gas exchange occurring in the alveoli iii. Confusion – elevated CO2 (hypercapnia) iv. Fatigue – increased energy expenditure due to breathing efforts v. Increased phlegm production – irritation and inflammation causing hyperplasia of mucus glands vi. Early satiety – caused by hyperinflation of the lungs within thoracic cavity vii. Dysgeusia and bitter tasting food – breathing through the mouth and medications may alter taste perception viii. Weight loss – increased breathing efforts and nutrient utilization b. Now identify at least four features of the physician’s physical examination consistent with admitting diagnosis. Describe the pathophysiology that might be responsible for each physical finding. i. ii. iii. iv. 1+ bilateral pitting edema – renal response to hypercapnia Decreased breathing sounds – destruction of alveoli Wheezing – obstruction in the airway Prolonged expiration – damaged alveoli from emphysema 5. Mrs. Bernhardt’s medical record indicates previous pulmonary function tests as follows: baseline FEV1=0.7 L, FVC=1.5 L, FEV1/FVC= 46%. Define FEV, FEV, and FEV/FVC, and indicate how they are used in the diagnosis of COPD. How can these measurements be used in treating COPD? a. FEV1 (forced expiratory volume) – volume of air exhaled in the first second of expiration b. FVC (forced vital capacity) – total volume of air expired after a respiration c. FEV/FVC – percentage of air expelled in the first second The values are representative of the presence or absence and degree of obstruction of the airways. The FEV decreases as COPD progresses. A normal FEV/FVC ratio is a approximately 70-80%; a smaller value indicates obstructive disease. 6. Look at Mrs. Bernhardt’s arterial blood gas values from the day she was admitted. a. Why would arterial blood gases (ABGs) be drawn for this patient? Blood gases would be evaluated because gas exchange is a concern among COPD patients. ABG values can measure lung function determine if the patient requires assisted ventilation. b. Define each of the following and interpret Mrs. Bernhardt’s values: i. pH: measure of hydrogen ion concentration in the blood, indicating acidity or alkalinity. Mrs. Bernhardt’s value was 7.29 upon admission, slightly acidic. ii. pCO2: partial pressure of CO2 dissolved in the blood; it measures how well CO2 moves from blood to lungs for exhalation. Mrs. Bernhardt’s value upon admission is 50.9, indicating her aveoli’s inability to exchange gases and retention of CO2 in her system. iii. SO2: percentage of hemoglobin saturated with oxygen. Mrs. Bernhardt’s SO2 value low upon admission, indicating her blood is inefficiently carrying oxygen to tissues. iv. HCO3-: a buffer to prevent acidosis; Mrs. Bernhardt’s elevated level of 29.6 at admission may indicate her body was trying to prevent her respiratory acidosis. c. Mrs. Bernhardt was placed on oxygen therapy. What lab values tell you the therapy is working? Mrs. Bernhardt’s pH and HCO3- have returned to normal, meaning her blood is less acidic, and indication of a decrease in CO2 in her blood. Her pCO2 is also back to normal, indicating the ratio of oxygen to carbon dioxide is normalized. 7. Mrs. Bernhardt has quit smoking. Shouldn’t her condition now improve? Explain. Mrs. Bernhardt was exposed to tobacco smoke for the majority of her life. The inflammatory response will continue to damage the lungs even after quitting. Although the symptoms can be treated, the damage in the alveoli is permanent. Her condition will not improve, but she has at least, eliminated the main cause of damage. 8. What is respiratory quotient? How is this figure related to nutritional intake and respiratory status? The RQ is ratio of the amount CO2 produced to the amount of O2 consumed. A diet high in carbohydrates will increase the RQ. The closer the RQ is to 1.0, the more CO2 is being produced, which places a strain on the respiratory system. Nutritional intake should be at a balance between macronutrients so the RQ does not reach too high of a value. Some evidence has shown diets higher in fat can help keep the RQ low enough to not cause additional damage. RQ is also a measure of indirect calorimetry, the gold standard of assessing energy needs. 9. What are the most common nutritional concerns for someone with COPD? Why is the patient diagnosed with COPD at higher risk for malnutrition? Nutritional concerns for COPD include osteoporosis, anemia, vitamin deficiencies and malnutrition. Malnutrition is of particularly importance because it is associated with increased mortality among COPD patients. Malnutrition affects more than just skeletal muscles; respiratory muscles begin wasting as well, creating a decreased capacity to breathe properly and exacerbating the initial breathing problems. The patient’s body is increasing the effort to breathe, therefore expending more energy than it is receiving. Patients tend to decrease their intake for a variety of reasons including shortness of breath, early satiety, altered tastes, and physical exhaustion. However, a COPD patient should not be overfed. Too many total calories can result in added stress to the respiratory system. Obesity can also place added stress onto the lungs, so weight reduction should be a priority among obese patients. 10. Is there specific nutrition therapy prescribed for these patients? While there is not a specific diet for COPD patients, there are many recommendations to reduce the stress on the respiratory system. COPD patients should receive up to 130% of resting energy expenditure to avoid malnutrition, but should never exceed 150% of REE as this can result in overfeeding and added stress. A mix of nutrients is essential to preserve lean body mass and general well-being. COPD patients should receive plenty of protein, about 1.2-1.5 g/kg/day and 1520% of their diet. This amount will help them maintain respiratory muscles and avoid malnutrition. Although carbohydrates contribute the greatest CO2 production after being metabolized, COPD patients require these nutrients to function. The intake should be monitored so it does implement too much stress on the patient’s breathing. Since too many carbohydrates can place additional stress on a COPD patient, they should receive plenty of calories from healthy fats. A recommendation for the amount of fat is 30-45% of total calories. Diets rich in fruits, vegetables, and fish have resulted in a lower incidence of COPD when compared to a diet consisting of refined grains, red meat, sweets, and fried foods. Antioxidants can help prevent damage caused by pollutants and tend to be depleted in COPD patients Diets higher in fat and lower in carbohydrates result in a lower RQ, meaning less stress on the lungs. COPD patients are at risk of osteoporosis and should monitor their calcium and phosphate levels Fluid intake should not be too high since edema can occur, but should be adequate to prevent dehydration Resting before meals and eating smaller meals can help with fatigue and feeling full 11. Calculate Mrs. Bernhardt’s %UBW and BMI. Does either of these values indicate she is at nutritional risk? How would her 1+ bilateral pitting edema affect evaluation of her weight? UBW = 145-150 lbs %UBW = 119/145 x 100 119/150 x 100 Current wt = 119 lbs = 82% = 79% %UBW = 79 to 82% BMI = 54kg/1.62 = 21.1 Since she has gradually lost weight over time, the change does not seem significant. Her BMI is normal. The fluid retention evidenced by her edema could cause her weight to be higher than it actually is. This would cause a greater difference in her weight change and a falsely high BMI even though she may be malnourished. 12. Calculate arm muscle area using the anthropometric data for mid-arm muscle circumference (MAC) and triceps skinfold (TSF). How would this data be interpreted? AMA = [MAC – (π x TSF)] 2 = [19.05cm – (π x 15mm)]2 = 62.7 4xπ 4xπ The Frishancho anthropometric standard for TSF places the patient below the 10th %ile, meaning that 90% of women have higher body fat than her. The Frishancho anthropometric standard for AMA places her above the 95th %ile, showing she has above average somatic stores. This can be interpreted as her weight loss resulting from fat loss instead of lean mass loss. 13. Calculate Mrs. Bernhardt’s energy and protein requirements. What activity and stress factor would you use? What is your rationale? 25-30 g/kg method: 30 kcal/kg if younger than 80 yo: 30 x 54kg ≈ 1600 kcal/day MSJ: 10(54kg) + 6.25(160cm) – 5(62) – 161 = 1040 kcal x 1.4 ≈ 1350 kcal/day HB: 655.1 + 9.6(54kg) + 1.9(160cm) – 4.7(62) = 1186 x 1.3 ≈ 1550 kcal/day I multiplied the REE’s by a factor of 1.3. This is a factor seemed adequate maintain body weight and prevent malnutrition, but it is not too high to be considered overfeeding and excessive CO2 production, which can begin above 150% REE. Protein 1.2-1.7g/kg/day: 1.2 x 54kg = 69; 1.7 x 54kg=92 70-90 grams protein/day 14. Using Mrs. Bernhardt’s nutrition history and 24-hour recall as a reference, does she have an adequate oral intake? Explain. 24 hour recall: Breakfast: ½ c coffee with non-dairy creamer, few sips of orange juice, ½ c oatmeal with 1 tsp sugar Lunch: ¾ c chicken noodle soup, 2 saltine crackers, ½ c coffee with non-dairy creamer; 32 oz pepsi throughout the day 710 calories, 164 g carbohydrates, 5 g fiber, 9 g protein (5% of calories), 6 g fat (7.5% of calories) Mrs. Bernhardt does not have an adequate energy intake. With 710 calories, she is consuming less than 50% of her estimated energy needs of 1350-1600 kcals/day. Her protein requirements are 70-90g/kg/day, but she is only consuming 9 grams. She has lost 20 lbs in the past year and is 20% below her usual body weight. 15. Evaluate Mrs. Bernhardt’s laboratory values. Identify those that are abnormal. Which of these may be used to assess her nutrition status? Mrs. Bernhardt’s total protein and albumin are low, which could indicate malnutrition. Her WBC is high, indicating a sign of infection. Her hematocrit, hemoglobin and RBC are low, a sign of anemia, especially her hemoglobin and hematocrit. A change in her low pH, high PCO2, low O2 saturation, high CO2 content, low O2 content indicates oxygen therapy is working. Her high base difference and HCO3 could mean her body was trying to counteract respiratory acidosis. 16. Why may Mrs. Bernhardt be at risk for anemia? Does her laboratory values indicate that she is anemic? Anemia is quite prevalent in chronic diseases including COPD. Although the exact mechanism is not known, inflammation is believed to be the cause. Mrs. Bernhardt’s low intake of energy may also be contributing to anemia. Her decreased hemoglobin, hematocrit, and red blood cell values are all decreased, indicating anemia. Although anemia is common in chronic diseases, these values may be low when excess fluid is present. Mrs. Bernhardt also has edema, so further testing should take place to diagnose anemia. 17. What factors can you identify from her nutrition interview that probably contributes to her difficulty in eating? Mrs. Bernhardt states that her appetite is poor, she fills up quickly, finds meal preparation challenging, is often too tired to eat, coughs to the point where she cannot eat, does not enjoy the taste of her food, and has loose dentures. 18. Select two high-priority nutrition problems and complete the PES statement for each. a. Self-feeding difficulty (NB-2.6) related to patient’s shortness of breath and fatigue during mealtimes as evidenced by a 20 lb weight loss in one year and a 24-hour recall revealing an intake significantly less than her required energy, nutrients, and fluid needs. b. Food and nutrition-related knowledge deficit (NB-1.1) related to misinformation about milk and dairy products as evidenced by an absence of calcium-rich foods in patient’s diet and confirmation of avoidance of these foods. 19. What is the current recommendation on the appropriate mix of calories from carbohydrates, protein, and lipid for this patient? A high consumption of carbohydrates can place additional stress on the respiratory system and the body by increasing the amount of carbon dioxide. A high-fat, lowcarbohydrate diet has been shown to provide adequate amounts of energy to avoid maintain body weight, but not exacerbate lung distress. COPD patients should consume a diet with a mix of 30-45% fat, and 15-20% protein, and balance the carbohydrates lastly. 20. For each of the PES statements you have written establish an ideal goal (based on the etiology). Goal: Instruct patient to consume smaller, more frequent meals and rest before mealtime to avoid fatigue Improve quality of food consumed by choosing nutrient dense food, and nutrition supplements if necessary. Patient will be able to consume more nutrients in a smaller amount of time with nutrient dense food.. Goal: Inform patient that milk will not increase mucus production. Instruct her on the risk of osteoporosis in COPD and the importance of consuming enough calcium and vitamin D per day. Education should also include alternative sources if patient continues to refuse dairy. 21. What goals might you set for Mrs. Bernhardt as she is discharged and beginning pulmonary rehabilitation? Continue to avoid tobacco. Be sure to include nutrient-dense food such as colorful fruits and vegetables, lean meats and healthy fats in her diet. Avoid energy-dense food like refined grains, fatty meats, fried food, and sweets. Reduce her intake of soda. Include vitamin supplements if necessary. Do not avoid milk and other dairy foods, as they are important to prevent osteoporosis. 22. You are now seeing Mrs. Bernhardt at her second visit to pulmonary rehabilitation. She provides you with the following information from her food record. Her weight is now 116 lbs. She explains adjustment to her medications and oxygen at home has been difficult, so she hasn’t felt like eating very much. When you talk with her, you find she is hungriest in the morning, and often by evening she is too tired to eat. She is having no specific intolerances, but she does tell you she hasn’t consumed any milk products because she thought they would cause more sputum to be produced. Monday Breakfast: coffee, 1 c with 2 T nondairy creamer; orange ½ c; 1 poached egg; ½ slice of toast Lunch: ¼ tuna salad sandwich (3 T tuna salad on 1 slice wheat bread); coffee, 1 c with 2 T nondairy creamer. Supper: cream of tomato soup, 1 c; ½ slice toast; ½ banana; pepsi-approximately 36 oz Tuesday Breakfast: Coffee, 1 c with 2 T nondairy creamer, orange juice, ½ c, ½ c oatmeal with 2 T brown sugar Lunch: 1 chicken leg from Kentucky Fried Chicken; ½ c mashed potatoes; 2 T gravy; coffee, 1 c with 2 T nondairy creamer Supper: cheese, 2 oz; 8 saltine crackers; 1 can V8 juice (6 oz); pepsi, approximately 36 oz a. Is she meeting her calorie and protein goals? She consumed 1070 calories and 28 grams of protein on Monday, and 1500 calories and 40 grams of protein on Tuesday. Although she is consuming much more than last time, she is still not meeting her goals. b. What would you tell her regarding the use of supplements and or milk and sputum production? Although it is widely believed that milk causes an increase in mucus production, there is no substantial scientific evidence that disproves that thought. She should consider calcium and vitamin D supplements due to the risk of osteoporosis in COPD. c. Using information from her food diary as a teaching tool, identify three interventions you would propose for Mrs. Bernhardt to increase her calorie and protein intakes. Mrs. Bernhard should consume more milk and dairy products. They will add protein, fat, and calories to her diet. Mrs. Bernhardt should reduce the amount of pepsi she drinks throughout the day and increase her water intake. Mrs. Bernhardt’s diet is still lacking protein, vitamins and minerals, and overall energy. She should add a high calorie, high protein supplement that provides essential vitamins and minerals. References: Gottschlich MM, DeLegge MH, Guenter P, American Society for Parenteral and Enteral Nutrition. The A.S.P.E.N. nutrition support core curriculum: a case-based approach : the adult patient. Silver Spring, Md: American Society for Parenteral and Enteral Nutrition; 2007. Nahikian-Nelms M. Nutrition therapy and pathophysiology. Belmont, Calif: Wadsworth, Cengage Learning; 2011. Koehler, F., Doehner, W., Hoernig, S., Witt, C., Anker, S. D., & John, M. (2007). Anorexia in chronic obstructive pulmonary disease – association to cachexia and hormonal derangement, International Journal Cardiology, 119, 83-89 Varrasso, R., Fung, T. T., Hu, F. B., Willett, W., & Camargo, C. A. (2007). Prospective study of dietary patterns and chronic obstructive pulmonary disease among US men, Thorax, 62, 488-495 Gronberg, A. M., Slinde, F., Engstrom, C. P., Hulthen, L., & Larrson, S. (2005). Dietary problems in patients with severe chromic obstructive pulmonary disease, Journal of Human Nutrition and Diet, 18, 445-452 Vermeeren, M. A., Creutzberg, E. C., Schols, A. M., Postma, D. S., Pieters, W. R., Roldaan, A. C., & Wouters, E. F. (2006). Prevalence of nutritional depletion in a large out-patient population of patients with COPD, Respiratory Medicine, 100, 1349-1355 Kuo, C. D., Shiao, G. M., & Lee, J. D. (1993). The effects of high-fat and high-carbohydrate diet loads on gas exchange and ventilation in COPD patients and normal subjects, Chest, 104, 189196 Celli, B. R., MacNee, W. (2004). Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper, European Respiratory Journal, 23, 932-946 WebMD. (2011, May 4) COPD Symptoms. Retrieved September 29, 2013, from http://www.webmd.com/lung/copd/tc/chronic-obstructive-pulmonary-disease-copd-symptoms Nahikian-Nelms M. Nutrition therapy and pathophysiology. Belmont, CA: Wadsworth, Cengage Learning; 2011 St. Florian, I. (2009, February). Nutrition and COPD - Dietary considerations for better breathing. Today’s Dietitan: The Magazine for Nutrition Professionals. Retrieved September 30, 2013, from http://www.todaysdietitian.com/newarchives/td_020909p54.shtml Scwartz AG & Ruckdeschel, JC. Familial lung cancer, American Journal of Respiratory and Critical Care Medicine, 173, 16-22. (2006). Biskobing, D. M. (2002). COPD and osteoporosis. CHEST Journal, 121(2), 609-620. Yohannes, A. M., & Ershler, W. B. (2011). Anemia in COPD: a systematic review of the prevalence, quality of life, and mortality. Respiratory care, 56(5), 644-652. John, M., Hoernig, S., Doehner, W., Okonko, D. D., Witt, C., & Anker, S. D. (2005). Anemia and inflammation in COPD, Chest, 127, 825-829 Johns, D.P. and Pierce, R. (2003). Pocket Guide to Spirometry, San Francisco: McGraw Hill. Appendix C, 100-105 Valli, G., Fedeli, A., Antonucci, R., Paoletti, P., & Palange, P. (2004). Water and sodium imbalance in COPD patients. Monaldi Arch Chest Dis, 61(2), 112-116. Academy of Nutrition and Dietetics. Evidence Analysis Library. Retrieved September 30, 2013, from http://andevidencelibrary.com/template.cfm?key=2149&auth=1 Wuthrich, B., Schmid, A., Walther, B., & Sieber, R. (2005). Milk consumption does not lead to mucus production or occurence of asthma. Journal of the American College of Nutrition, 24(sup6), 547S-555S. Pinnock, C. B., Graham, N. M., Mylvaganam, A., & Douglas, R. M. (1990). Relationship between milk intake and mucus production in adult volunteers challenged with rhinovirus2. American Review Respiratory Distress, 14, 352-356. Ranu, H., Wilde, M., & Madden, B. (2011). Pulmonary function tests. Ulster Medical Journal, 80, 84-90. CHRONIC OBSTRUCTIVE PULMONARY DISEASE NUTRITION POCKET CARD Kevin Hernandez 10/07/2013 Definition A progressive disease that limits airflow through either inflammation of the bronchioles or destruction of alveoli. Diagnosis Diagnosis should be considered in patients with progressive dyspnea, chronic cough, chronic mucus production, and a history of exposure to tobacco smoke or other environmental risk factors. Spirometry Lung function tests are used to confirm diagnosis and monitor progression of disease. Forced Expiratory Volume in 1 second (FEV1): amount of air expired in the first second of exhalation Forced Vital Capacity (FVC): total amount of air expired during exhalation FEV1/FVC: Ratio of two values Stages of COPD 0 – at risk I – mild II – Moderate III - Severe IV – Very Severe Normal Spirometry FEV1 >80% FEV1 <80% FEV1 <50% FEV <30% or <50% with symptoms of respiratory failure Protein & Energy Requirements Calories o Mifflin-St Jeor: o Women: 655.1 + 9.6(wt in kg) + 1.9(ht in cm) -4.7(age) o Men: 66.5 + 13.8(wt in kg) + 50(ht in cm) – 6.8(age) o Mifflin-St Jeor: o Women: 10 (wt in kg) + 6.25 (ht in cm) – 5(age) – 161 o Men: 5 + 10(wt in kg) + 6.25(ht in cm) -5(age) + 5 o Kcal/kg Method: 30 kcal/kg Protein o High enough to stimulate protein synthesis, maintain lung strenght and prevent wasting o 1.2 – 1.7 g/kg/day to prevent Lab Values to Monitor pH pCO2 (mm Hg) satO2 (%) CO2 content (mmol/L) O2 content (%) Base deficit (<3) HCO3 (mEq/L) Ref. Range 7.35-7.45 35-45 >95 25-30 15-22 3.6 24-28 Goals of COPD Management Discontinue smoking (if current smoker) Relieve symptoms Prevent progression Reduce strenuous breathing efforts Improve overall health Prevent complications Reduce mortality Minimize side effects Nutrition Recommendations COPD patients should receive up to 130% of resting energy expenditure to avoid malnutrition, but should never exceed 150% of REE as this can result in overfeeding and added stress. COPD patients should receive plenty of protein, about 1.2-1.5 g/kg/day to maintain respiratory muscles and avoid malnutrition. Diets rich in fruits, vegetables, and fish have resulted in a lower incidence of COPD when compared to a diet consisting of refined grains, red meat, sweets, and fried foods. Antioxidants can help prevent damage caused by pollutants and tend to be depleted in COPD patients Diets higher in fat and lower in carbohydrates result in a lower RQ, meaning less stress on the lungs. COPD patients are at risk of osteoporosis and should monitor their calcium and phosphate levels Fluid intake should not be too high since edema can occur, but should be adequate to prevent dehydration Resting before meals and eating smaller meals can help with fatigue and feeling full Oxygen Therapy COPD patients may require O2 therapy. Begin O2 therapy if: Pa02 reaches below 55 mm Hg, or SaO2 is less than 88%, with or without hypercapnia or PaO2 is less than 60 mm Hg, or SO2 is 88%, and the presence of pulmonary hypertension, peripheral edema or polycythemia. References Gottschlich, M. M., DeLegge, M. H., Guenter, P., American Society for Parenteral and Enteral Nutrition. The A.S.P.E.N. nutrition support core curriculum: a case-based approach : the adult patient. Silver Spring, Md: American Society for Parenteral and Enteral Nutrition; 2007. Nahikian-Nelms M. Nutrition therapy and pathophysiology. Belmont, Calif: Wadsworth, Cengage Learning; 2011. Rodriguez-Roisin, R., Anzueto, A., Bourbeau, J. DeGuia, T. S., Hui, D., Jenkins, C., Martinez, F., Mishima, M., Montes de Oca, M., Stockley, R., van Weel, C., & Vestbo, J. (2010) Pocket guide to COPD diagnosis, management, and prevention, Global Initiative for Chronic Obstructive Lung Disease