Download Fig.1. Systematic review structure. 256 articles were founded in the

Fig.1. Systematic review structure.
256 articles
were
founded in
the first
search in
online
sources
50 articles
were critical
analyzed
with the
CONSORT
2010
checklist of
information
206 articles
were
excluded for
not fulfilling
the
inclusion
criteria
3 articles of
required
quality were
analyzed
with review
manager
software
47 articles
were
excluded
Table1. Included studies.
Study included
Intervention
Hyperfractionated radiation therapy
Addition of cisplatin to
As
with or without concurrent low-dose
hyperfractionation
radiotherapy
daily cisplatin in locally advanced
radiation therapy offers an
alone,
squamous cell carcinoma of the
advantage over the same
concurrent
head
treatment given alone in
cisplatin offered a survival
locally
advantage.
and
neck: a prospective
randomized trial8.
advanced
Outcome
compared
with
the
treatment
radiotherapy
and
low-dose
daily
squamous cell carcinoma
of the head and neck.
Five-year update of a randomized
Randomized trial
The superiority of alternating
trial of alternating radiotherapy and
chemotherapy
and
chemotherapy
radiotherapy
over
compared
with
radiotherapy alone in treatment of
radiotherapy alone in treating
unresectable
unresectable squamous cell
squamous
cell
carcinoma of the head and neck9
carcinoma of the head and
neck was confirmed at 5
years. However, additional
trials must be conducted
before
considering
combined
the
approach
as
standard therapy.
Randomized trial of radiotherapy
versus
chemoradiotherapy
concurrent
followed
by
adjuvant chemotherapy in patients
with American joint committee on
cancer/international union against
Randomized trial
This
study
confirms
that
chemotherapy improves the
distant
metastasis
rate in NPC
control
cancer
stage
nasopharyngeal
iii
cancer
and
iv
of
the
endemic variety10.
Fig.2. Meta-analysis forest plot.
Fig.3. Funnel Plot