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Date Lecture Topic 01/28/2016 02/04/2016 04/07/2016 04/14/2016 04/21/2016 04/28/2016 05/05/2016 Introduction to biology of the immune system. Innate Immunity. Complement system. Toll-like receptors-structure, function, cellular expression. Antigen recognition by B and T cells. Antibodies. B cell receptor structure and function. T cell surface receptor structure and function. Antigen presentation by MHCI and MHCII Generation of lymphocyte antigen receptors. Immunoglobulin gene rearrangement. Generation of antibody diversity. Synthesis, assembly, secretion of immunoglobulins. Antigen presentation. Generation of T cell receptor ligands. Signaling through immune receptors. Development and survival of B lymphocytes. Development of T lymphocytes The adaptive immune response. T cell mediated immunity Humoral immune response. Mechanisms of activation of B cells and T follicular helper cells. Antibody secretion and germinal center reaction. Class switching. Memory No class-Spring break Midterm exam Dynamics of the immune response. The immune response in health and disease. Allergy and hypersensitivity Transplantation Autoimmunity Immunity at mucosal surfaces. Review of the material 05/12/2016 Final Exam 02/11/2016 02/18/2016 02/25/2016 03/03/2016 03/10/2016 03/17/2016 03/24/2016 03/31/2016 Textbook Chapters (Janeway’s Immunobiology 8th edition) Chapter 1. Chapter 2. Chapter 3. Chapter 4. Chapter 5. Chapter 6. Chapter 7. Chapter 8. Chapter 8.Chapter 9. Chapter 10. Chapter 11. Chapter 14 Chapter 15 Chapter 15 Chapter 12